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Isolation of Live Human δ Cells for Genetic and Functional Analysis
Available online 11 June 2025, 102188Author links open overlay panel, , , , Highlights•Created a novel flow sorting strate...
Vitamin D receptor signalling regulates the diet-driven metabolic shift during weaning
ObjectiveWeaning in mammals is associated with a shift in the metabolism, driven by the differences in the macronutrient c...
14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation
ObjectiveWe previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis and adiposity, but...
Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index
ObjectiveThe cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associate...
Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism
ObjectiveMacrophage accumulation in metabolically active tissues during obesity is common in both animals and humans, but ...
Gut microbiota mediates SREBP-1c-driven hepatic lipogenesis and steatosis in response to zero-fat high-sucrose diet
ObjectivesSucrose-rich diets promote hepatic de novo lipogenesis (DNL) and steatosis through interactions with the gut mic...
Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health
ObjectiveWe previously identified tetraspanin 7 (Tspan7) as a candidate gene influencing body weight in an obesity-related...
Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting
ObjectiveThe capacity of the liver to serve as a peripheral sensor in the regulation of food intake has been debated for o...
IL-6 decodes sex and diet-dependent circadian and metabolic rhythms
ObjectiveInterleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation and energy metabolism. Its diurnal s...
Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease
Volume 97, July 2025, 102163Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•High-fat high...
Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK
The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to...
Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]
Volume 97, July 2025, 102160Author links open overlay panelSaran Lotfollahzadeh 1, Chaoshuang Xia 2, Razie Amraei 3, Ning ...
Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
ObjectiveThe adaptive response to different models of regular exercise involves complex tissue crosstalk. Our aim was to e...
JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism
ObjectiveHypothalamic energy sensors, such as AMP-activated protein kinase (AMPK), and stress sensors, such as c-Jun N-ter...
Uncovering the role of Gpr45 in obesity regulation
ObjectivesG protein-coupled receptors (GPCRs) are the most druggable targets in biology due to their cell-type specificity...
RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation
Single cell RNA sequencing data supporting the findings of this study have been deposited in NCBI's Gene Expression Omnibu...
Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis
ObjectivesAdipose tissue plays a critical role in obesity, as its dysfunction can impair lipid homeostasis and result in l...