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Isolation of Live Human δ Cells for Genetic and Functional Analysis

Available online 11 June 2025, 102188Author links open overlay panel, , , , Highlights•Created a novel flow sorting strate...

Molecular Metabolism

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Vitamin D receptor signalling regulates the diet-driven metabolic shift during weaning

ObjectiveWeaning in mammals is associated with a shift in the metabolism, driven by the differences in the macronutrient c...

Molecular Metabolism

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Effects of children's microbiota on adipose and intestinal development in sex-matched mice persist into adulthood following a single fecal microbiota transplantation

BackgroundThe global prevalence of obesity and type 2 diabetes, particularly among children, is rising, yet the long-term ...

Molecular Metabolism

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14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

ObjectiveWe previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis and adiposity, but...

Molecular Metabolism

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Hepatic stellate cell-specific Kcnma1 deletion mitigates metabolic dysfunction-associated steatotic liver disease progression via upregulating Amphiregulin secretion

ObjectiveMetabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, with limited...

Molecular Metabolism

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Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index

ObjectiveThe cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associate...

Molecular Metabolism

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Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism

ObjectiveMacrophage accumulation in metabolically active tissues during obesity is common in both animals and humans, but ...

Molecular Metabolism

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Gut microbiota mediates SREBP-1c-driven hepatic lipogenesis and steatosis in response to zero-fat high-sucrose diet

ObjectivesSucrose-rich diets promote hepatic de novo lipogenesis (DNL) and steatosis through interactions with the gut mic...

Molecular Metabolism

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Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health

ObjectiveWe previously identified tetraspanin 7 (Tspan7) as a candidate gene influencing body weight in an obesity-related...

Molecular Metabolism

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Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting

ObjectiveThe capacity of the liver to serve as a peripheral sensor in the regulation of food intake has been debated for o...

Molecular Metabolism

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Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice

ObjectiveAcidic extracellular microenvironments, resulting from enhanced glycolysis and lactic acid secretion by immune ce...

Molecular Metabolism

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IL-6 decodes sex and diet-dependent circadian and metabolic rhythms

ObjectiveInterleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation and energy metabolism. Its diurnal s...

Molecular Metabolism

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Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease

Volume 97, July 2025, 102163Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•High-fat high...

Molecular Metabolism

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Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to...

Molecular Metabolism

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Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]

Volume 97, July 2025, 102160Author links open overlay panelSaran Lotfollahzadeh 1, Chaoshuang Xia 2, Razie Amraei 3, Ning ...

Molecular Metabolism

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Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice

ObjectiveThe adaptive response to different models of regular exercise involves complex tissue crosstalk. Our aim was to e...

Molecular Metabolism

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JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism

ObjectiveHypothalamic energy sensors, such as AMP-activated protein kinase (AMPK), and stress sensors, such as c-Jun N-ter...

Molecular Metabolism

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Uncovering the role of Gpr45 in obesity regulation

ObjectivesG protein-coupled receptors (GPCRs) are the most druggable targets in biology due to their cell-type specificity...

Molecular Metabolism

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RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation

Single cell RNA sequencing data supporting the findings of this study have been deposited in NCBI's Gene Expression Omnibu...

Molecular Metabolism

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Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis

ObjectivesAdipose tissue plays a critical role in obesity, as its dysfunction can impair lipid homeostasis and result in l...

Molecular Metabolism

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Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels