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NEJM Endocrinology
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SCI Abstract
search
ALL
RECOMMENDED
+
Isolation of Live Human δ Cells for Genetic and Functional Analysis
Available online 11 June 2025, 102188Author links open overlay panel, , , , Highlights•Created a novel flow sorting strate...
Molecular Metabolism
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Vitamin D receptor signalling regulates the diet-driven metabolic shift during weaning
ObjectiveWeaning in mammals is associated with a shift in the metabolism, driven by the differences in the macronutrient c...
Molecular Metabolism
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Effects of children's microbiota on adipose and intestinal development in sex-matched mice persist into adulthood following a single fecal microbiota transplantation
BackgroundThe global prevalence of obesity and type 2 diabetes, particularly among children, is rising, yet the long-term ...
Molecular Metabolism
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14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation
ObjectiveWe previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis and adiposity, but...
Molecular Metabolism
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Hepatic stellate cell-specific Kcnma1 deletion mitigates metabolic dysfunction-associated steatotic liver disease progression via upregulating Amphiregulin secretion
ObjectiveMetabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, with limited...
Molecular Metabolism
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Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index
ObjectiveThe cellular composition and functionality of adipose tissue are key determinants of metabolic diseases associate...
Molecular Metabolism
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Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism
ObjectiveMacrophage accumulation in metabolically active tissues during obesity is common in both animals and humans, but ...
Molecular Metabolism
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Gut microbiota mediates SREBP-1c-driven hepatic lipogenesis and steatosis in response to zero-fat high-sucrose diet
ObjectivesSucrose-rich diets promote hepatic de novo lipogenesis (DNL) and steatosis through interactions with the gut mic...
Molecular Metabolism
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Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health
ObjectiveWe previously identified tetraspanin 7 (Tspan7) as a candidate gene influencing body weight in an obesity-related...
Molecular Metabolism
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Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting
ObjectiveThe capacity of the liver to serve as a peripheral sensor in the regulation of food intake has been debated for o...
Molecular Metabolism
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Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice
ObjectiveAcidic extracellular microenvironments, resulting from enhanced glycolysis and lactic acid secretion by immune ce...
Molecular Metabolism
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IL-6 decodes sex and diet-dependent circadian and metabolic rhythms
ObjectiveInterleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation and energy metabolism. Its diurnal s...
Molecular Metabolism
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Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease
Volume 97, July 2025, 102163Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•High-fat high...
Molecular Metabolism
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Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK
The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to...
Molecular Metabolism
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Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]
Volume 97, July 2025, 102160Author links open overlay panelSaran Lotfollahzadeh 1, Chaoshuang Xia 2, Razie Amraei 3, Ning ...
Molecular Metabolism
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Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
ObjectiveThe adaptive response to different models of regular exercise involves complex tissue crosstalk. Our aim was to e...
Molecular Metabolism
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JNK1 in SF1 neurons regulates the central action of thyroid hormones on hepatic lipid metabolism
ObjectiveHypothalamic energy sensors, such as AMP-activated protein kinase (AMPK), and stress sensors, such as c-Jun N-ter...
Molecular Metabolism
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Uncovering the role of Gpr45 in obesity regulation
ObjectivesG protein-coupled receptors (GPCRs) are the most druggable targets in biology due to their cell-type specificity...
Molecular Metabolism
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RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation
Single cell RNA sequencing data supporting the findings of this study have been deposited in NCBI's Gene Expression Omnibu...
Molecular Metabolism
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Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis
ObjectivesAdipose tissue plays a critical role in obesity, as its dysfunction can impair lipid homeostasis and result in l...
Molecular Metabolism
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Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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miR-10a regulates cell death and inflammation in adipose tissue of male mice with diet-induced obesity
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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Mammalian D-Cysteine controls insulin secretion in the pancreas
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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Protein kinase D2 modulates hepatic insulin sensitivity in male mice
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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A novel long non-coding RNA connects obesity to impaired adipocyte function
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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TGF-β antagonism synergizes with PPARγ agonism to reduce fibrosis and enhance beige adipogenesis
Update your browser to view ScienceDirect. ...
Molecular Metabolism
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