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Changes in eating behavior and diet-related quality of life in individuals treated with tirzepatide for type 2 diabetes
Changes in eating behavior and diet-related quality of life in individuals treated with tirzepatide for type 2 diabetes
We investigated changes in eating behavior associated with the administration of tirzepatide and evaluated any changes in ...
Insulin resistance and cognitive decline: the metabolic mechanisms linking type 2 diabetes to Alzheimer’s disease
Insulin resistance and cognitive decline: the metabolic mechanisms linking type 2 diabetes to Alzheimer’s disease
Alzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) share overlapping pathophysiological pathways, includin...
Diabetes mellitus narrows frequency band range of low-frequency components in heart rate variability
Diabetes mellitus narrows frequency band range of low-frequency components in heart rate variability
It is well known that the power of low-frequency and high-frequency components of heart rate variability decreases in indi...
Is once-weekly insulin a viable alternative for type 2 diabetes? A meta-analysis of randomized controlled trials
Is once-weekly insulin a viable alternative for type 2 diabetes? A meta-analysis of randomized controlled trials
Once-weekly novel insulin preparations such as Icodec and basal insulin Fc (BIF)/insulin Efsitora Alfa have raised hope am...
Real-world use of finerenone in diabetic kidney disease: eGFR slope analysis with exploratory data on prior MRA use
Real-world use of finerenone in diabetic kidney disease: eGFR slope analysis with exploratory data on prior MRA use
In the post-SGLT2 inhibitor era, residual renal risk remains a major concern in diabetic kidney disease (DKD). Finerenone,...
Biomarker signatures distinguish diabetic retinopathy and diabetic nephropathy
Biomarker signatures distinguish diabetic retinopathy and diabetic nephropathy
This study aims to identify distinct sets of genes that can serve as specific biomarkers reflective of biological states d...
Dynamic changes of blood glucose level during capivasertib treatment in metastatic breast cancer: a case report
Dynamic changes of blood glucose level during capivasertib treatment in metastatic breast cancer: a case report
Hyperglycemia is a well-recognized adverse event associated with capivasertib, an oral AKT inhibitor, and may occasionally...
Role of metallothionein 3 in diabetic nephropathy via interplay with HIF-1α
Role of metallothionein 3 in diabetic nephropathy via interplay with HIF-1α
Metallothioneins (MTs) are a cysteine-rich protein that scavenges reactive oxygen species. Hypoxia is involved in the prog...
Prevalence and risk factors for skeletal muscle mass loss in individuals with type 1 diabetes
Prevalence and risk factors for skeletal muscle mass loss in individuals with type 1 diabetes
This study aimed to the investigate prevalence and factors associated with reduced skeletal muscle mass in non-elderly adu...
Blood cell HbA1c measured by enzymatic assay show higher than whole blood HbA1c in patients with iron deficiency anemia
Blood cell HbA1c measured by enzymatic assay show higher than whole blood HbA1c in patients with iron deficiency anemia
In Japan, most HbA1c measurements by enzymatic assays or immunoassays represent the HbA1c levels in the blood cell fractio...
Systemic lupus erythematosus and pulmonary tuberculosis in a patient developing acute-onset type 1 diabetes
Systemic lupus erythematosus and pulmonary tuberculosis in a patient developing acute-onset type 1 diabetes
A 73-year-old Japanese woman was admitted to our hospital with anorexia, weight loss, and fever. A few weeks prior to admi...
Differentiation, reduction, and proliferation of pancreatic β-cells and their regulatory factors
Differentiation, reduction, and proliferation of pancreatic β-cells and their regulatory factors
The prevalence of diabetes has increased rapidly in recent years, and many types of therapeutic agents have been developed...
Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells
Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells
Endoplasmic reticulum (ER) stress due to obesity or systemic insulin resistance is an important pathogenic factor that cou...
Regulation of glucose metabolism by incretins: implications for treatment of type 2 diabetes
Regulation of glucose metabolism by incretins: implications for treatment of type 2 diabetes
Gastrointestinal hormones that potentiate insulin secretion from pancreatic β-cells are called incretins. Glucose-dep...
Long-term effects of esaxerenone in patients with type 2 diabetes, diabetic kidney disease, and hypertension (JDDM77)
Long-term effects of esaxerenone in patients with type 2 diabetes, diabetic kidney disease, and hypertension (JDDM77)
This clinical study assessed the three-year, long-term effects of esaxerenone, a non-steroidal aldosterone receptor blocke...
Pathophysiological hallmarks in type 2 diabetes heterogeneity (review)
Pathophysiological hallmarks in type 2 diabetes heterogeneity (review)
The mechanistic complexity in type 2 diabetes (T2DM) is primarily responsible for the degrees of heterogeneity and develop...