Pathophysiological hallmarks in type 2 diabetes heterogeneity (review)

Singer EM, Dorrance AK, Oxenreiter MM, Yan RK, Close LK. The type 2 diabetes ‘modern preventable pandemic’ and replicable lessons from the COVID-19 crisis. Prev Med Rep. 2022;25: 101636.

Article  PubMed  Google Scholar 

Pradeepa R, Mohan V. Epidemiology of type 2 diabetes in India. Indian J Ophthalmol. 2021;69(11):2932–8.

Article  PubMed  PubMed Central  Google Scholar 

Cohrs MC, Panjer KJ, Drotar MD, Enos JS, et al. Dysfunction of persisting beta cells is a key feature of early type 2 diabetes pathogenesis. Cell Rep. 2020;31(1): 107469.

Article  CAS  PubMed  Google Scholar 

Bellary S, Kyrou I, Brown JE, et al. Type 2 diabetes mellitus in older adults: clinical considerations and management. Nat Rev Endocrinol. 2021;17:534–48.

Article  PubMed  Google Scholar 

Tomic D, Shaw JE, Magliano DJ. The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol. 2022;18(9):525–39.

Article  PubMed  PubMed Central  Google Scholar 

Harding JL, Pavkov ME, Magliano DJ, et al. Global trends in diabetes complications: a review of current evidence. Diabetologia. 2019;62:3–16.

Article  PubMed  Google Scholar 

Nolan JJ, Kahkoska RA, Azad SZ, et al. ADA/EASD precision medicine in diabetes initiative: an international perspective and future vision for precision medicine in diabetes. Diabetes Care. 2022;45(2):261–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowman P, Flanagan ES, Hattersley TA. Future roadmaps for precision medicine applied to diabetes: rising to the challenge of heterogeneity. J Diabetes Res. 2018;2018:3061620.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lonardo A, Byrne DC, Targher G. Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going? Metab Target Organ Damage. 2021;1:3.

CAS  Google Scholar 

Herder C, Roden M. A novel diabetes typology: towards precision diabetology from pathogenesis to treatment. Diabetologia. 2022;65(11):1770–81.

Article  PubMed  PubMed Central  Google Scholar 

Mohan V, Radha V. Precision diabetes is slowly becoming a reality. Med Princ Pract. 2019;28(1):1–9.

Article  PubMed  PubMed Central  Google Scholar 

Ommen VB, Wopereis S, van Empelen P, et al. From diabetes care to diabetes cure—the integration of systems biology, eHealth, and behavioral change. Front Endocrinol (Lausanne). 2018;8:381.

Article  PubMed  PubMed Central  Google Scholar 

Chung KW, Erion K, Florez CJ, Hattersley TA, et al. Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2020;63(9):1671–93.

Article  PubMed  PubMed Central  Google Scholar 

Daryabor G, Atashzar RM, Kabelitz D, Meri S, Kalantar K. The effects of type 2 diabetes mellitus on organ metabolism and the immune system. Front Immunol. 2020;11:1582.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giri B, Dey S, Das T, Sarkar M, Banerjee J, Das KS. Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other physiological consequences: An update on glucose toxicity. Biomed Pharmacother. 2018;107:306–28.

Article  CAS  PubMed  Google Scholar 

Chait A, den Hartigh JL. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mayoral CPL, Andrade MG, Mayoral CPE. Obesity subtypes, related biomarkers & heterogeneity. Indian J Med Res. 2020;151(1):11–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Longo M, Bellastella G, Maiorino IM, et al. Diabetes and aging: from treatment goals to pharmacologic therapy. Front Endocrinol (Lausanne). 2019;10:45.

Article  PubMed  PubMed Central  Google Scholar 

Tabak GA, Herder C, Rathmann W, Brunner JE, Kivimaki M. Prediabetes: a high-risk state for developing diabetes. Lancet. 2012;379(9833):2279–90.

Article  PubMed  PubMed Central  Google Scholar 

Kaneto H, Obata A, Kimura T, Shimoda M, et al. Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: pleiotropic roles of incretin and insulin signaling. Int J Mol Sci. 2020;21(24):9444.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nasteska D, Hodson JD. The role of beta cell heterogeneity in islet function and insulin release. J Mol Endocrinol. 2018;61(1):R43–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutierrez DG, Gromada J, Sussel L. Heterogeneity of the pancreatic beta cell. Front Genet. 2017;8:22.

Article  PubMed  PubMed Central  Google Scholar 

Benninger PKR, Kravets V. The physiological role of β-cell heterogeneity in pancreatic islet function. Nat Rev Endocrinol. 2022;18(1):9–22.

Article  CAS  PubMed  Google Scholar 

Larsen GP, French EJ, Moussa MN, Voruganti SV, et al. Synergizing mouse and human studies to understand the heterogeneity of obesity. Adv Nutr. 2021;12(5):2023–34.

Article  Google Scholar 

Dutta D, Mukhopadhyay S. Novel diabetes subgroups. Lancet Diabetes Endocrinol. 2018;6(6):438.

Article  PubMed  Google Scholar 

Dennis MJ, Shields MB, Henley EW, Jones GA, Hattersley TA. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. Lancet Diabetes Endocrinol. 2019;7(6):442–51.

Article  PubMed  PubMed Central  Google Scholar 

Selvaraj R, Rajappa M, Shamanna SB. Phenotypic characterization of patients with type 2 diabetes mellitus. Int J Diabetes Dev Ctries. 2020;40:242–7.

Article  CAS  Google Scholar 

Ahlqvist E, Storm P, Karajamaki A, Martinell M, et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018;6(5):361–9.

Article  PubMed  Google Scholar 

Redondo JM, Hagopian AW, Oram R, Steck KA, et al. The clinical consequences of heterogeneity within and between different diabetes types. Diabetologia. 2020;63(10):2040–8.

Article  PubMed  PubMed Central  Google Scholar 

Nazarzadeh M, Bidel Z, Canoy D, Copland E, et al. Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis. Lancet. 2021;398(10313):1803–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marchetti P, Bugliani M, Tata DV, Suleiman M, Marselli L. Pancreatic beta cell identity in humans and the role of type 2 diabetes. Front Cell Dev Biol. 2017;5:55.

Article  PubMed  PubMed Central  Google Scholar 

Gerber AP, Rutter AG. The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus. Antioxid Redox Signal. 2017;26(10):501–18.

Comments (0)

No login
gif