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Neutrophils in Inflammatory Bone Diseases
Neutrophils in Inflammatory Bone Diseases
In this review, we summarize the current evidence that suggests that neutrophils play a key role in facilitating damage to...
Diagnosing Osteoporosis in Diabetes—A Systematic Review on BMD and Fractures
Diagnosing Osteoporosis in Diabetes—A Systematic Review on BMD and Fractures
Recently, the American Diabetes Association updated the 2024 guidelines for Standards of Care in Diabetes and recommend th...
Osteocytes and Paget’s Disease of Bone
Osteocytes and Paget’s Disease of Bone
To describe the contributions of osteocytes to the lesions in Paget’s disease, which are characterized by locally ov...
Osteoimmunology of Fracture Healing
Osteoimmunology of Fracture Healing
The purpose of this review is to summarize what is known in the literature about the role inflammation plays during bone f...
Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function
Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function
This review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses...
Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential
Quercetin in Osteoporosis Treatment: A Comprehensive Review of Its Mechanisms and Therapeutic Potential
This review aims to provide a theoretical basis and insights for quercetin’s clinical application in the prevention ...
Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models
Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models
To illustrate the value of using zebrafish to understand the role of the Fgf signaling pathway during craniofacial skeleta...
Efferocytosis and Bone Dynamics
Efferocytosis and Bone Dynamics
This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and...
Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging
Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging
In this review, we discuss the most recent scientific advances on the reciprocal regulatory interactions between the skele...
Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development
Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development
Along with a strong impact on skeletal integrity, bone marrow adipose tissue (BMAT) is an important modulator of the adult...
2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS)
2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS)
Quantification of the morphology of osteocyte lacunae has become a powerful tool to investigate bone metabolism, pathologi...
Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss
Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss
Beyond aging, senescent cells accumulate during multiple pathological conditions, including chemotherapy, radiation, gluco...
Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints
Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints
Recently, photon-counting computed tomography (PCCT) has been introduced in clinical research and diagnostics. This review...
Persistent uncertainties in optimal treatment approaches of secondary hyperparathyroidism and hyperphosphatemia in patients with chronic kidney disease
Persistent uncertainties in optimal treatment approaches of secondary hyperparathyroidism and hyperphosphatemia in patients with chronic kidney disease
This review is a critical analysis of treatment results obtained in clinical trials conducted in patients with chronic kid...
MicroRNAs and their Modulatory Effect on the Hallmarks of Osteosarcopenia
MicroRNAs and their Modulatory Effect on the Hallmarks of Osteosarcopenia
Osteosarcopenia is a geriatric syndrome associated with disability and mortality. This review summarizes the key microRNAs...
Practical Compass of Single-Cell RNA-Seq Analysis
Practical Compass of Single-Cell RNA-Seq Analysis
This review paper provides step-by-step instructions on the fundamental process, from handling fastq datasets to illustrat...
Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis
Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis
We primarily aim to review differences in bone mineral density (BMD) for osteoporosis among different racial/ethnic groups...
Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation
Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation
To summarize what is known about the deleterious effect of hip fracture on muscle mass and strength as well as the scienti...
Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting
Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting
This review aims to explore the potential of biomimetic hydrogels as an alternative to bone cement in vertebral body stent...
Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies
Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies
GWAS, as a largely correlational analysis, requires in vitro or in vivo validation. Zebrafish (Danio rerio) have many adva...
Weight-bearing Guidelines for Common Geriatric Upper and Lower Extremity Fractures
Weight-bearing Guidelines for Common Geriatric Upper and Lower Extremity Fractures
The purpose of this review paper is to summarize current weight-bearing guidelines for common geriatric fractures, around ...
Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging
Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging
Summarize the recent literature that investigates how advanced medical imaging has contributed to our understanding of ske...
Bone Material Properties in Bone Diseases Affecting Children
Bone Material Properties in Bone Diseases Affecting Children
Metabolic and genetic bone disorders affect not only bone mass but often also the bone material, including degree of miner...
Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease
Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease
As the importance of osteocytes for bone mineral homeostasis is increasingly recognized, there is growing interest in oste...
Correction: Bringing Mechanical Context to Image-Based Measurements of Bone Integrity
Correction: Bringing Mechanical Context to Image-Based Measurements of Bone Integrity
Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, 105 Administration Place, Saskatoon, SK, S...
The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting
The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting
Here, we discuss the origin of chondrocytes, their destiny, and their plasticity in relationship to bone growth, articulat...
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts
Metformin is an anti-glycemic agent, which is widely prescribed to diabetes patients. Although its alleged role on bone st...
Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research
Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research
The integration of data from multiple genomic assays from humans and non-human model organisms is an effective approach to...
Novel Insights into Osteoclast Energy Metabolism
Novel Insights into Osteoclast Energy Metabolism
Osteoclasts are crucial for the dynamic remodeling of bone as they resorb old and damaged bone, making space for new bone....
Inflammatory Processes Affecting Bone Health and Repair
Inflammatory Processes Affecting Bone Health and Repair
The purpose of this article is to review the current understanding of inflammatory processes on bone, including direct imp...
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