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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women
Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women
Several studies report an impact of the neurotransmitter dopamine (DA) on human immune cells, with effects dependent on th...
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis
Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis
Parkinson’s disease (PD) is more prevalent in men than women, and presents with different clinical features in each ...
Sex and hand differences in haptic processing: implications for mental rotation ability
Sex and hand differences in haptic processing: implications for mental rotation ability
It has been proposed that the sensorimotor system provides a foundation for the development of cognitive abilities and the...
Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia
Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia
Significant sex differences exist in the prevalence and incidence of Alzheimer’s disease (AD). Notably, testosterone...
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
Female sex and Apolipoprotein (APOE) ε4 genotype are top risk factors for late-onset Alzheimer’s disease. This ...
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank
Sex-specific associations of Notch signaling with chronic HBV infection: a study from Taiwan Biobank
Hepatitis B, a liver infection caused by the hepatitis B virus (HBV), can develop into a chronic infection that puts patie...
Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis
Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis
Blotched snakehead (Channa maculata) displays significant sexual dimorphism, with males exhibiting faster growth rates and...
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice
Early life adversity impairs hippocampal development and function across diverse species. While initial evidence indicated...
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Fatty Liver Index (FLI) is the best score to predict MASLD with 50% lower cut-off value in women than in men
Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the presence of hepatic steatosis, detected...
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cor...
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene
Celiac disease (CeD) is an immune-mediated disorder that develops in genetically predisposed individuals upon gluten consu...
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Sex differences in type 2 diabetes: an opportunity for personalized medicine
Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With ne...
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
Univariate and multivariate sex differences and similarities in gray matter volume within essential language-processing areas
Sex differences in language-related abilities have been reported. It is generally assumed that these differences stem from...
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metaboli...
Sex differences in the rapid detection of neutral faces associated with emotional value
Sex differences in the rapid detection of neutral faces associated with emotional value
Rapid detection of faces with emotional meaning is essential for understanding the emotions of others, possibly promoting ...
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities
The gut microbiome has been linked to many diseases with sex bias including autoimmune, metabolic, neurological, and repro...
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats
Sex differences have been observed in several brain regions for the molecular mechanisms involved in baseline (resting) an...
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia
Gestational sleep apnea is a hypoxic sleep disorder that affects 8–26% of pregnancies and increases the risk for cen...
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice
Binge alcohol drinking is a risk factor linked to numerous disease states including alcohol use disorder (AUD). While men ...
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
Correction: Variability of temperature measurements recorded by a wearable device by biological sex
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
Monopterus albus is a hermaphroditic fish with sex reversal from ovaries to testes via the ovotestes in the process of gon...
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in i...
Sex-specific role of galectin-3 in aortic stenosis
Sex-specific role of galectin-3 in aortic stenosis
Aortic stenosis (AS) is characterized by inflammation, fibrosis, osteogenesis and angiogenesis. Men and women develop thes...
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory cells that secrete the hormones vas...
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Sex differences in the association between adipose insulin resistance and non-alcoholic fatty liver disease in Chinese adults
Adipose insulin resistance (Adipo-IR) is associated with multiple metabolic diseases, including non-alcoholic fatty liver ...
Endothelin mediates sex-differences in acclimation to high salt diet in rats
Endothelin mediates sex-differences in acclimation to high salt diet in rats
Current understanding of sodium (Na+) handling is based on studies done primarily in males. Contrary to the gradual increa...
Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection
Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infection
To examine the expression characteristics of single nucleotide polymorphisms (SNPs) in the SRD5A2 gene and investigate the...
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity
We have previously reported that maternal obesity reduces placental transport capacity for lysophosphatidylcholine-docosah...
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
Paraoxonase 2 (PON2) and neuronal uncoupling proteins (UCP4 and UCP5) possess antioxidant, anti-apoptotic activit...
Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice
Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice
In addition to social and cultural factors, sex differences in the central nervous system have a critical influence on beh...
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