Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats

2024 Alzheimer’s disease facts and figures. Alzheimers Dement J Alzheimers Assoc. 2024;20(5):3708–821.

Isik AT. Late onset Alzheimer’s disease in older people. Clin Interv Aging. 2010;5:307–11.

Article  PubMed  PubMed Central  Google Scholar 

Barnes LL, Wilson RS, Bienias JL, Schneider JA, Evans DA, Bennett DA. Sex differences in the clinical manifestations of Alzheimer Disease Pathology. Arch Gen Psychiatry. 2005;62(6):685–91.

Article  PubMed  Google Scholar 

Ferretti MT, Iulita MF, Cavedo E, Chiesa PA, Schumacher Dimech A, Santuccione Chadha A, et al. Sex differences in Alzheimer disease — the gateway to precision medicine. Nat Rev Neurol. 2018;14(8):457–69.

Article  PubMed  Google Scholar 

Irvine K, Laws K, Gale T, Kondel K. Greater cognitive deterioration in women than men with Alzheimer’s disease: a meta analysis. J Clin Exp Neuropsychol. 2012;34.

Mielke MM, Vemuri P, Rocca WA. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clin Epidemiol. 2014;6:37–48.

Article  PubMed  PubMed Central  Google Scholar 

Van Cauwenberghe C, Van Broeckhoven C, Sleegers K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet Med. 2016;18(5):421–30.

Article  PubMed  Google Scholar 

Liu CC, Zhao N, Fu Y, Wang N, Linares C, Tsai CW, et al. ApoE4 accelerates early seeding of amyloid pathology. Neuron. 2017;96(5):1024–e10323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem. 2013;288(8):5914–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ulrich JD, Ulland TK, Mahan TE, Nyström S, Nilsson KP, Song WM, et al. ApoE facilitates the microglial response to amyloid plaque pathology. J Exp Med. 2018;215(4):1047–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Altmann A, Tian L, Henderson VW, Greicius MD. Sex modifies the APOE-Related risk of developing Alzheimer’s Disease. Ann Neurol. 2014;75(4):563–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balu D, Valencia-Olvera AC, Islam Z, Mielczarek C, Hansen A, Ramos TMP, et al. APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice. Front Aging Neurosci. 2023;15:1279343.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duarte-Guterman P, Albert AY, Barha CK, Galea LAM, on behalf of the Alzheimer’s Disease Neuroimaging Initiative. Sex influences the effects of APOE genotype and Alzheimer’s diagnosis on neuropathology and memory. Psychoneuroendocrinology. 2021;129:105248.

Article  CAS  PubMed  Google Scholar 

Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, et al. Sex-Specific Association of Apolipoprotein E with cerebrospinal fluid levels of tau. JAMA Neurol. 2018;75(8):989–98.

Article  PubMed  PubMed Central  Google Scholar 

Sohn D, Shpanskaya K, Lucas JE, Petrella JR, Saykin AJ, Tanzi RE, et al. Sex differences in Cognitive decline in subjects with high likelihood of mild cognitive impairment due to Alzheimer’s disease. Sci Rep. 2018;8(1):7490.

Article  PubMed  PubMed Central  Google Scholar 

Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of Age, Sex, and ethnicity on the Association between Apolipoprotein E Genotype and Alzheimer Disease: a Meta-analysis. JAMA. 1997;278(16):1349–56.

Article  CAS  PubMed  Google Scholar 

Riedel BC, Thompson PM, Brinton RD, Age. APOE and sex: Triad of risk of Alzheimer’s disease. J Steroid Biochem Mol Biol. 2016;160:134–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ekonomou A, Savva GM, Brayne C, Forster G, Francis PT, Johnson M, et al. Stage-specific changes in Neurogenic and glial markers in Alzheimer’s Disease. Biol Psychiatry. 2015;77(8):711–9.

Article  CAS  PubMed  Google Scholar 

Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW. Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer’s disease. Hum Brain Mapp. 2010;31(9):1339–47.

Article  PubMed  PubMed Central  Google Scholar 

Rao YL, Ganaraja B, Murlimanju BV, Joy T, Krishnamurthy A, Agrawal A. Hippocampus and its involvement in Alzheimer’s disease: a review. 3 Biotech. 2022;12(2):55.

Article  PubMed  PubMed Central  Google Scholar 

Thal DR, Holzer M, Rüb U, Waldmann G, Günzel S, Zedlick D, et al. Alzheimer-Related τ-Pathology in the Perforant path Target Zone and in the hippocampal stratum Oriens and Radiatum correlates with Onset and Degree of Dementia. Exp Neurol. 2000;163(1):98–110.

Article  CAS  PubMed  Google Scholar 

Gage FH. Adult neurogenesis in mammals. Science. 2019;364(6443):827–8.

Article  CAS  PubMed  Google Scholar 

Knoth R, Singec I, Ditter M, Pantazis G, Capetian P, Meyer RP, et al. Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS ONE. 2010;5(1):e8809.

Article  PubMed  PubMed Central  Google Scholar 

Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, et al. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron. 2022;110(3):452–69.

Article  CAS  PubMed  Google Scholar 

Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555(7696):377–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gallardo-Caballero M, Rodríguez-Moreno CB, Álvarez-Méndez L, Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, et al. Prolonged fixation and post-mortem delay impede the study of adult neurogenesis in mice. Commun Biol. 2023;6(1):1–12.

Article  Google Scholar 

Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, et al. Human adult neurogenesis: evidence and remaining questions. Cell Stem Cell. 2018;23(1):25–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Rodríguez-Moreno CB, Márquez-Valadez B, Gallardo-Caballero M, et al. Methods to study adult hippocampal neurogenesis in humans and across the phylogeny. Hippocampus. 2023;33(4):271–306.

Article  CAS  PubMed  Google Scholar 

Terstege DJ, Addo-Osafo K, Campbell Teskey G, Epp JR. New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue. Mol Brain. 2022;15(1):38.

Article  PubMed  PubMed Central  Google Scholar 

Abrous DN, Wojtowicz JM. Interaction between Neurogenesis and hippocampal memory system: New Vistas. Cold Spring Harb Perspect Biol. 2015;7(6):a018952.

Article  PubMed  PubMed Central  Google Scholar 

Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, et al. Hum Hippocampal Neurogenesis Persists throughout Aging Cell Stem Cell. 2018;22(4):589–e5995.

CAS  Google Scholar 

Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, et al. Neurogenesis in the adult human hippocampus. Nat Med. 1998;4(11):1313–7.

Article  CAS  PubMed 

Comments (0)

No login
gif