2024 Alzheimer’s disease facts and figures. Alzheimers Dement J Alzheimers Assoc. 2024;20(5):3708–821.
Isik AT. Late onset Alzheimer’s disease in older people. Clin Interv Aging. 2010;5:307–11.
Article PubMed PubMed Central Google Scholar
Barnes LL, Wilson RS, Bienias JL, Schneider JA, Evans DA, Bennett DA. Sex differences in the clinical manifestations of Alzheimer Disease Pathology. Arch Gen Psychiatry. 2005;62(6):685–91.
Ferretti MT, Iulita MF, Cavedo E, Chiesa PA, Schumacher Dimech A, Santuccione Chadha A, et al. Sex differences in Alzheimer disease — the gateway to precision medicine. Nat Rev Neurol. 2018;14(8):457–69.
Irvine K, Laws K, Gale T, Kondel K. Greater cognitive deterioration in women than men with Alzheimer’s disease: a meta analysis. J Clin Exp Neuropsychol. 2012;34.
Mielke MM, Vemuri P, Rocca WA. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clin Epidemiol. 2014;6:37–48.
Article PubMed PubMed Central Google Scholar
Van Cauwenberghe C, Van Broeckhoven C, Sleegers K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet Med. 2016;18(5):421–30.
Liu CC, Zhao N, Fu Y, Wang N, Linares C, Tsai CW, et al. ApoE4 accelerates early seeding of amyloid pathology. Neuron. 2017;96(5):1024–e10323.
Article CAS PubMed PubMed Central Google Scholar
Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem. 2013;288(8):5914–26.
Article CAS PubMed PubMed Central Google Scholar
Ulrich JD, Ulland TK, Mahan TE, Nyström S, Nilsson KP, Song WM, et al. ApoE facilitates the microglial response to amyloid plaque pathology. J Exp Med. 2018;215(4):1047–58.
Article CAS PubMed PubMed Central Google Scholar
Altmann A, Tian L, Henderson VW, Greicius MD. Sex modifies the APOE-Related risk of developing Alzheimer’s Disease. Ann Neurol. 2014;75(4):563–73.
Article CAS PubMed PubMed Central Google Scholar
Balu D, Valencia-Olvera AC, Islam Z, Mielczarek C, Hansen A, Ramos TMP, et al. APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice. Front Aging Neurosci. 2023;15:1279343.
Article CAS PubMed PubMed Central Google Scholar
Duarte-Guterman P, Albert AY, Barha CK, Galea LAM, on behalf of the Alzheimer’s Disease Neuroimaging Initiative. Sex influences the effects of APOE genotype and Alzheimer’s diagnosis on neuropathology and memory. Psychoneuroendocrinology. 2021;129:105248.
Article CAS PubMed Google Scholar
Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, et al. Sex-Specific Association of Apolipoprotein E with cerebrospinal fluid levels of tau. JAMA Neurol. 2018;75(8):989–98.
Article PubMed PubMed Central Google Scholar
Sohn D, Shpanskaya K, Lucas JE, Petrella JR, Saykin AJ, Tanzi RE, et al. Sex differences in Cognitive decline in subjects with high likelihood of mild cognitive impairment due to Alzheimer’s disease. Sci Rep. 2018;8(1):7490.
Article PubMed PubMed Central Google Scholar
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of Age, Sex, and ethnicity on the Association between Apolipoprotein E Genotype and Alzheimer Disease: a Meta-analysis. JAMA. 1997;278(16):1349–56.
Article CAS PubMed Google Scholar
Riedel BC, Thompson PM, Brinton RD, Age. APOE and sex: Triad of risk of Alzheimer’s disease. J Steroid Biochem Mol Biol. 2016;160:134–47.
Article CAS PubMed PubMed Central Google Scholar
Ekonomou A, Savva GM, Brayne C, Forster G, Francis PT, Johnson M, et al. Stage-specific changes in Neurogenic and glial markers in Alzheimer’s Disease. Biol Psychiatry. 2015;77(8):711–9.
Article CAS PubMed Google Scholar
Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW. Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer’s disease. Hum Brain Mapp. 2010;31(9):1339–47.
Article PubMed PubMed Central Google Scholar
Rao YL, Ganaraja B, Murlimanju BV, Joy T, Krishnamurthy A, Agrawal A. Hippocampus and its involvement in Alzheimer’s disease: a review. 3 Biotech. 2022;12(2):55.
Article PubMed PubMed Central Google Scholar
Thal DR, Holzer M, Rüb U, Waldmann G, Günzel S, Zedlick D, et al. Alzheimer-Related τ-Pathology in the Perforant path Target Zone and in the hippocampal stratum Oriens and Radiatum correlates with Onset and Degree of Dementia. Exp Neurol. 2000;163(1):98–110.
Article CAS PubMed Google Scholar
Gage FH. Adult neurogenesis in mammals. Science. 2019;364(6443):827–8.
Article CAS PubMed Google Scholar
Knoth R, Singec I, Ditter M, Pantazis G, Capetian P, Meyer RP, et al. Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS ONE. 2010;5(1):e8809.
Article PubMed PubMed Central Google Scholar
Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, et al. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron. 2022;110(3):452–69.
Article CAS PubMed Google Scholar
Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, et al. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555(7696):377–81.
Article CAS PubMed PubMed Central Google Scholar
Gallardo-Caballero M, Rodríguez-Moreno CB, Álvarez-Méndez L, Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, et al. Prolonged fixation and post-mortem delay impede the study of adult neurogenesis in mice. Commun Biol. 2023;6(1):1–12.
Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, et al. Human adult neurogenesis: evidence and remaining questions. Cell Stem Cell. 2018;23(1):25–30.
Article CAS PubMed PubMed Central Google Scholar
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Rodríguez-Moreno CB, Márquez-Valadez B, Gallardo-Caballero M, et al. Methods to study adult hippocampal neurogenesis in humans and across the phylogeny. Hippocampus. 2023;33(4):271–306.
Article CAS PubMed Google Scholar
Terstege DJ, Addo-Osafo K, Campbell Teskey G, Epp JR. New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue. Mol Brain. 2022;15(1):38.
Article PubMed PubMed Central Google Scholar
Abrous DN, Wojtowicz JM. Interaction between Neurogenesis and hippocampal memory system: New Vistas. Cold Spring Harb Perspect Biol. 2015;7(6):a018952.
Article PubMed PubMed Central Google Scholar
Boldrini M, Fulmore CA, Tartt AN, Simeon LR, Pavlova I, Poposka V, et al. Hum Hippocampal Neurogenesis Persists throughout Aging Cell Stem Cell. 2018;22(4):589–e5995.
Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, et al. Neurogenesis in the adult human hippocampus. Nat Med. 1998;4(11):1313–7.
Comments (0)