Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice

Makino Y, Kanno R, Ito T, Higashino K, Taniguchi M. Predominant expression of invariant Vα14+ TCR α chain in NK11+ T cell populations. Int Immunol. 1995;7(7):1157–61.

Article  CAS  PubMed  Google Scholar 

Van Kaer L, Joyce S. Innate immunity: NKT cells in the spotlight. Curr Biol. 2005;15(11):R429–31.

Article  PubMed  Google Scholar 

Van Kaer L, Parekh VV, Wu L. Invariant natural killer T cells: bridging innate and adaptive immunity. Cell Tissue Res. 2011;343(1):43–55.

Article  CAS  PubMed  Google Scholar 

Wang H, Yin S. Natural killer T cells in liver injury, inflammation and cancer. Expert Rev Gastroenterol Hepatol. 2015;9(8):1077–85.

Article  CAS  PubMed  Google Scholar 

Dasgupta S, Kumar V. Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset. Immunogenetics. 2016;68(8):665–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu S, Zhang H, Bai L. NKT cells in liver diseases. Front Med. 2018;12(3):249–61.

Article  PubMed  Google Scholar 

Joyce S, Girardi E, Zajonc DM. NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. J Immunol Baltim Md. 2011;187(3):1081–9.

CAS  Google Scholar 

Crosby CM, Kronenberg M. Tissue-specific functions of invariant natural killer T cells. Nat Rev Immunol. 2018;18(9):559–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slauenwhite D, Johnston B. Regulation of NKT cell localization in homeostasis and infection. Front Immunol. 2015;6:255.

Article  PubMed  PubMed Central  Google Scholar 

Sebode M, Wigger J, Filpe P, Fischer L, Weidemann S, Krech T, et al. Inflammatory phenotype of intrahepatic sulfatide-reactive type II NKT cells in humans with autoimmune hepatitis. Front Immunol. 2019;10(MAY):31191516.

Google Scholar 

Gao B, Radaeva S, Park O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol. 2009;86(3):513–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dhodapkar MV, Kumar V. Type II NKT cells and their emerging role in health and disease. J Immunol Baltim Md 1950. 2017;198(3):1015–21.

CAS  Google Scholar 

Kumar A, Suryadevara N, Hill TM, Bezbradica JS, Van Kaer L, Joyce S. Natural killer T cells: an ecological evolutionary developmental biology perspective. Front Immunol. 2017;8:1858.

Article  PubMed  PubMed Central  Google Scholar 

Bandyopadhyay K, Marrero I, Kumar V. NKT cell subsets as key participants in liver physiology and pathology. Cell Mol Immunol. 2016;13(3):337–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA. Tissue-specific distribution of iNKT cells impacts their cytokine response. Immunity. 2015;43(3):566–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol. 2004;23(1):877–900.

Article  Google Scholar 

Yang JQ, Zhou Y, Singh RR. Effects of invariant NKT cells on parasite infections and hygiene hypothesis. Shanker A, editor. J Immunol Res. 2016;2016:2395645.

Article  PubMed  PubMed Central  Google Scholar 

Tessmer MS, Fatima A, Paget C, Trottein F, Brossay L. NKT cell immune responses to viral infection. Expert Opin Ther Targets. 2009;13(2):153–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Terabe M, Berzofsky JA. Tissue-specific roles of NKT cells in tumor immunity. Front Immunol. 2018;9:1838.

Article  PubMed  PubMed Central  Google Scholar 

Van Kaer L, Wu L. Therapeutic potential of invariant natural killer T cells in autoimmunity. Front Immunol. 2018;9:519.

Article  PubMed  PubMed Central  Google Scholar 

Parisi L, Bassani B, Tremolati M, Gini E, Farronato G, Bruno A. Natural killer cells in the orchestration of chronic inflammatory diseases, Bagatini MD, editor. J Immunol Res. 2017;2017:4218254.

Article  PubMed  PubMed Central  Google Scholar 

Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023;S0168–8278(23)00418-X.

Van Herck MA, Weyler J, Kwanten WJ, Dirinck EL, De Winter BY, Francque SM, et al. The differential roles of T cells in non-alcoholic fatty liver disease and obesity. Front Immunol. 2019;10:82.

Article  PubMed  PubMed Central  Google Scholar 

Powell EE, Wong VWS, Rinella M. Non-alcoholic fatty liver disease. Lancet Lond Engl. 2021;397(10290):2212–24.

Article  CAS  Google Scholar 

Lazarus JV, Mark HE, Anstee QM, Arab JP, Batterham RL, Castera L, et al. Advancing the global public health agenda for NAFLD: a consensus statement. Nat Rev Gastroenterol Hepatol. 2022;19(1):60–78.

Article  CAS  PubMed  Google Scholar 

Iruzubieta P, Bataller R, Arias-Loste MT, Arrese M, Calleja JL, Castro-Narro G, et al. Research priorities for precision medicine in NAFLD. Clin Liver Dis. 2023;27(2):535–51.

Article  PubMed  Google Scholar 

Kanwal F, Shubrook JH, Younossi Z, Natarajan Y, Bugianesi E, Rinella ME, et al. Preparing for the NASH epidemic: a call to action. Gastroenterology. 2021;161(3):1030-1042.e8.

Article  PubMed  Google Scholar 

Schattenberg JM, Lazarus JV, Newsome PN, Serfaty L, Aghemo A, Augustin S, et al. Disease burden and economic impact of diagnosed non-alcoholic steatohepatitis in five European countries in 2018: a cost-of-illness analysis. Liver Int Off J Int Assoc Study Liver. 2021;41(6):1227–42.

Google Scholar 

Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the study of liver diseases. Hepatol Baltim Md. 2018;67(1):328–57.

Article  Google Scholar 

Lonardo A, Nascimbeni F, Ballestri S, Fairweather D, Win S, Than TA, et al. Sex differences in nonalcoholic fatty liver disease: state of the art and identification of research gaps. Hepatology. 2019;70(4):1457–69.

Article  CAS  PubMed  Google Scholar 

Guebre-Xabier M, Yang S, Lin HZ, Schwenk R, Krzych U, Diehl AM. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage. Hepatology. 2000;31(3):633–40.

Article  CAS  PubMed  Google Scholar 

Ma X, Hua J, Li Z. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol. 2008;49(5):821–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Eshima K, et al. Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance. PLoS ONE. 2012;7(2): e30568.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathews S, Feng D, Maricic I, Ju C, Kumar V, Gao B. Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration. Cell Mol Immunol. 2016;13(2):206–16.

Article  CAS  PubMed  Google Scholar 

Sutti S, Jindal A, Locatelli I, Vacchiano M, Gigliotti L, Bozzola C, et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatol Baltim Md. 2014;59(3):886–97.

Article  CAS  Google Scholar 

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, et al. Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes. Cancer Cell. 2014;26(4):549–64.

Article  CAS  PubMed  Google Scholar 

Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, et al. NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. Gut. 2012;61(9):1323–9.

Article  CAS  PubMed  Google Scholar 

Syn WK, Oo YH, Pereira TA, Karaca GF, Jung Y, Omenetti A, et al. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatol Baltim Md. 2010;51(6):1998–2007.

Article  CAS  Google Scholar 

Miyagi T, Takehara T, Uemura A, Nishio K, Shimizu S, Kodama T, et al. Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet. J Gastroenterol. 2010;45(12):1247–54.

Article  CAS  PubMed  Google Scholar 

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