Baloch, Z. W. et al. Overview of the 2022 WHO classification of thyroid neoplasms. Endocr. Pathol. 33, 27–63 (2022). This article provides an overview of the new 2022 WHO classification of thyroid tumours, with a focus on pathological aspects.

Article  PubMed  Google Scholar 

Fagin, J. A. & Wells, S. A. Jr Biologic and clinical perspectives on thyroid cancer. N. Engl. J. Med. 375, 2307 (2016).

Article  PubMed  Google Scholar 

Haugen, B. R. et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26, 1–133 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Christofer Juhlin, C., Mete, O. & Baloch, Z. W. The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading. Endocr. Relat. Cancer 30, e220293 (2023).

Article  CAS  PubMed  Google Scholar 

Bible, K. C. et al. 2021 American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer. Thyroid 31, 337–386 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Asioli, S. et al. Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression. Mod. Pathol. 23, 1269–1278 (2010).

Article  PubMed  Google Scholar 

Wong, K. S. et al. Papillary thyroid carcinoma with high-grade features versus poorly differentiated thyroid carcinoma: an analysis of clinicopathologic and molecular features and outcome. Thyroid 31, 933–940 (2021).

Article  CAS  PubMed  Google Scholar 

Martinez-Jimenez, F. et al. A compendium of mutational cancer driver genes. Nat. Rev. Cancer 20, 555–572 (2020).

Article  CAS  PubMed  Google Scholar 

Taylor, A. M. et al. Genomic and functional approaches to understanding cancer aneuploidy. Cancer Cell 33, 676–689 e673 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma. Cell 159, 676–690 (2014). This comprehensive genomic and transcriptomic characterization by the TCGA research network defines the main molecular and phenotypic features of PTCs.

Article  Google Scholar 

Mitsutake, N. et al. Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells. Cancer Res. 65, 2465–2473 (2005).

Article  CAS  PubMed  Google Scholar 

Lito, P. et al. Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell 22, 668–682 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knauf, J. A. et al. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res. 65, 4238–4245 (2005). This paper reports that thyroid-specific expression of BRAFV600Ein vivo was able to promote PTC development.

Article  CAS  PubMed  Google Scholar 

Franco, A. T. et al. Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc. Natl Acad. Sci. USA 108, 1615–1620 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charles, R. P., Iezza, G., Amendola, E., Dankort, D. & McMahon, M. Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse. Cancer Res. 71, 3863–3871 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vitagliano, D. et al. Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas. Oncogene 25, 5467–5474 (2006).

Article  CAS  PubMed  Google Scholar 

Chen, X. et al. Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene. Proc. Natl Acad. Sci. USA 106, 7979–7984 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller, K. A. et al. Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo. Cancer Res. 69, 3689–3694 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung, S. H. et al. Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. Oncotarget 7, 69638–69648 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Hudson, T. J. et al. Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage? J. Otolaryngol. Head. Neck Surg. 52, 12 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Veschi, V. et al. Recapitulating thyroid cancer histotypes through engineering embryonic stem cells. Nat. Commun. 14, 1351 (2023). This paper shows that CRISPR-mediated editing of BRAF, RAS and TP53 mutations recapitulate specific thyroid histotypes, particularly when generated in thyroid progenitor cells.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stosic, A. et al. Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma. Cancer Res. 81, 5625–5637 (2021).

Article  CAS  PubMed  Google Scholar 

Franco, A. T. et al. Fusion oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers. J. Clin. Oncol. 40, 1081–1090 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ricarte-Filho, J. C. et al. Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers. J. Clin. Invest. 123, 4935–4944 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morton, L. M. et al. Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident. Science 372, eabg2538 (2021). The most comprehensive genomic characterization of thyroid cancers linked to the Chernobyl nuclear plant accident, showing a radiation dose-dependent increase in DNA double-strand breaks and the generation of fusion drivers.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, J. et al. Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels. Mol. Endocrinol. 17, 1425–1436 (2003).

Article  CAS  PubMed  Google Scholar 

Jhiang, S. M. et al. Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137, 375–378 (1996).

Article  CAS  PubMed  Google Scholar 

Santoro, M. et al. Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice. Oncogene 12, 1821–1826 (1996).

CAS  PubMed  Google Scholar 

Powell, D. J. Jr. et al. The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res. 58, 5523–5528 (1998).

CAS  PubMed  Google Scholar 

Bongarzone, I. et al. High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma. Oncogene 4, 1457–1462 (1989).

CAS  PubMed  Google Scholar 

Kelly, L. M. et al. Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer. Proc. Natl Acad. Sci. USA 111, 4233–4238 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikitski, A. V. et al. Mouse model of poorly differentiated thyroid carcinoma driven by STRN-ALK fusion. Am. J. Pathol. 188, 2653–2661 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russell, J. P. et al. The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium. Oncogene 19, 5729–5735 (2000).

Article  CAS  PubMed  Google Scholar 

Yoo, S. K. et al. Comprehensive analysis of the transcriptional and mutational landscape of follicular and papillary thyroid cancers. PLoS Genet. 12, e1006239 (2016). This paper reports the genomic and transcriptomic characteristics of FTCs, and compares them with other benign and malignant thyroid lesions with follicular growth patterns.

Article  PubMed  PubMed Central  Google Scholar 

Nicolson, N. G. et al. Comprehensive genetic analysis of follicular thyroid carcinoma predicts prognosis independent of histology. J. Clin. Endocrinol. Metab. 103, 2640–2650 (2018).

Article  PubMed  Google Scholar 

Kroll, T. G. et al. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. Science 289, 1357–1360 (2000).

Article  CAS  PubMed  Google Scholar 

Raman, P. & Koenig, R. J. Pax-8–PPAR-γ fusion protein in thyroid carcinoma. Nat. Rev. Endocrinol. 10, 616–623 (2014).