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Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Variant Transthyretin Amyloid Cardiomyopathy
Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Variant Transthyretin Amyloid Cardiomyopathy
Transthyretin amyloidosis (ATTR) is a progressive, heterogeneous rare disease manifesting as ATTR polyneuropathy (ATTR-PN)...
Derivation of Stroke Volume from Pulmonary Artery Pressures
Derivation of Stroke Volume from Pulmonary Artery Pressures
Intermittent cardiac output (CO) studies using thermodilution are considered the gold standard. We have developed a stroke...
Tafamidis 61 mg Patient Characteristics and Persistency? A Retrospective Analysis of German Statutory Health Insurance Data (IQVIA™ LRx)
Tafamidis 61 mg Patient Characteristics and Persistency? A Retrospective Analysis of German Statutory Health Insurance Data (IQVIA™ LRx)
Tafamidis is the first drug approved by the European Commission for the treatment of wild-type or hereditary transthyretin...
Broadening Perspectives of Artificial Intelligence in Echocardiography
Broadening Perspectives of Artificial Intelligence in Echocardiography
Echocardiography frequently serves as the first-line treatment of diagnostic imaging for several pathological entities in ...
Milvexian: An Oral, Bioavailable Factor XIa Inhibitor
Milvexian: An Oral, Bioavailable Factor XIa Inhibitor
Direct oral anticoagulants have a dose-dependent increased bleeding risk which limits use in certain populations. Studies ...
Safety and Effectiveness of Four-Factor Prothrombin Complex Concentrate in Special Populations with INR Below 2: A Post-Marketing Surveillance Study
Safety and Effectiveness of Four-Factor Prothrombin Complex Concentrate in Special Populations with INR Below 2: A Post-Marketing Surveillance Study
We previously conducted a prospective, observational post-marketing surveillance study to assess the safety and effectiven...
Prevalence of Tendon Rupture and Tendinopathies Among Patients with Atherosclerotic Cardiovascular Disease Derived From United States Administrative Claims Data
Prevalence of Tendon Rupture and Tendinopathies Among Patients with Atherosclerotic Cardiovascular Disease Derived From United States Administrative Claims Data
The prevalence of tendon rupture and tendinopathies (TRT) has not been determined in a large population of patients with a...
Narrative Review: Surgical and Hybrid Management of Atrial Fibrillation
Narrative Review: Surgical and Hybrid Management of Atrial Fibrillation
Although significant strides have been made in non-pharmacologic management of atrial fibrillation (AF), these treatments ...
Prognostic Implications of Coronary Artery Sclerosis in Troponin-Positive Patients with Non-Obstructive Coronary Arteries
Prognostic Implications of Coronary Artery Sclerosis in Troponin-Positive Patients with Non-Obstructive Coronary Arteries
Coronary sclerosis is a risk factor for the progression to obstructive coronary artery disease (CAD). However, understandi...
Implementing a Quality Intervention to Improve Confidence in Outpatient Venous Thromboembolism Management
Implementing a Quality Intervention to Improve Confidence in Outpatient Venous Thromboembolism Management
Guidelines recommend that patients with acute venous thromboembolism (VTE) represented by low-risk deep vein thrombosis (D...
All-Cause Mortality of Atrial Fibrillation and Heart Failure in the Same Patient: Does the Order Matter?
All-Cause Mortality of Atrial Fibrillation and Heart Failure in the Same Patient: Does the Order Matter?
Atrial fibrillation (AF) and heart failure (HF) often coexist due to the common elements of the pathomechanism they share....
Pharmacodynamic Comparison of Two Aspirin Formulations in the Caribbean: The ARC Study
Pharmacodynamic Comparison of Two Aspirin Formulations in the Caribbean: The ARC Study
This prospective, single-arm, crossover pharmacodynamic study assessed the effect of Bayer® low-dose enteric-coated a...
Ten-year Durability, Hemodynamic Performance, and Clinical Outcomes after Transcatheter Aortic Valve Implantation Using a Self-expanding Device
Ten-year Durability, Hemodynamic Performance, and Clinical Outcomes after Transcatheter Aortic Valve Implantation Using a Self-expanding Device
The expansion of transcatheter aortic valve implantation (TAVI) to low-risk and younger patients has increased the relevan...
Recent Advances in Targeted Management of Inflammation In Atherosclerosis: A Narrative Review
Recent Advances in Targeted Management of Inflammation In Atherosclerosis: A Narrative Review
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality despite effective low-de...
National Trends in Aspirin Use and Expenditures in the United States: Analysis of The Medical Expenditure Panel Survey 2000–2021
National Trends in Aspirin Use and Expenditures in the United States: Analysis of The Medical Expenditure Panel Survey 2000–2021
Since its invention in 1897, aspirin (ASA) has been the most widely used and cost-effective antiplatelet agent to prevent ...
Clinical and Genotype Characteristics and Symptom Migration in Patients With Mixed Phenotype Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey
Clinical and Genotype Characteristics and Symptom Migration in Patients With Mixed Phenotype Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey
Transthyretin amyloidosis (ATTR amyloidosis) is primarily associated with a cardiac or neurologic phenotype, but a mixed p...
Can Artificial Intelligence Improve the Readability of Patient Education Materials on Aortic Stenosis? A Pilot Study
Can Artificial Intelligence Improve the Readability of Patient Education Materials on Aortic Stenosis? A Pilot Study
The advent of generative artificial intelligence (AI) dialogue platforms and large language models (LLMs) may help facilit...
Add-on Sacubitril/Valsartan Therapy Induces Left Ventricular Remodeling in Non-responders to Cardiac Resynchronization Therapy to a Similar Extent as in Heart Failure Patients Without Resynchronization
Add-on Sacubitril/Valsartan Therapy Induces Left Ventricular Remodeling in Non-responders to Cardiac Resynchronization Therapy to a Similar Extent as in Heart Failure Patients Without Resynchronization
Non-responders to cardiac resynchronization therapy (CRT-NR) have poor prognosis. Sacubitril/valsartan (SV) treatment impr...
Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results
Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results
The aim of this sub-study was to evaluate the relationship between echocardiography (echo) and cardiac magnetic resonance ...
Real-World Risk of Recurrent Cardiovascular Events in Atherosclerotic Cardiovascular Disease Patients with LDL-C Above Guideline-Recommended Threshold: A Retrospective Observational Study
Real-World Risk of Recurrent Cardiovascular Events in Atherosclerotic Cardiovascular Disease Patients with LDL-C Above Guideline-Recommended Threshold: A Retrospective Observational Study
The 2021 Canadian Cardiovascular Society (CCS) guidelines recommend intensive low-density lipoprotein cholesterol (LDL-C) ...
Factor XI Inhibitors: A New Horizon in Anticoagulation Therapy
Factor XI Inhibitors: A New Horizon in Anticoagulation Therapy
Anticoagulation therapy has undergone significant evolution, marked by the emergence of direct oral anticoagulants with di...
Real-World Safety and Effectiveness of a 4-Factor Prothrombin Complex Concentrate in Japanese Patients Experiencing Major Bleeding: A Post-marketing Surveillance Study
Real-World Safety and Effectiveness of a 4-Factor Prothrombin Complex Concentrate in Japanese Patients Experiencing Major Bleeding: A Post-marketing Surveillance Study
Limited data are available regarding the safety and effectiveness of 4-factor prothrombin complex concentrate (4F-PCC) in ...
Contemporary Management of Cardiomyopathy and Heart Failure in Pregnancy
Contemporary Management of Cardiomyopathy and Heart Failure in Pregnancy
Cardiovascular disease is the primary cause of pregnancy-related mortality and morbidity in the United States, and materna...
Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation Using the Sentinel Cerebral Protection System: A Systematic Review and Meta-Analysis
Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation Using the Sentinel Cerebral Protection System: A Systematic Review and Meta-Analysis
Transcatheter aortic valve implantation (TAVI) plays a vital role in patients with symptomatic aortic stenosis. Despite th...
Single-Pill, Triple Antihypertensive Therapy in Rural Sub-Saharan Africa: Preliminary Experience
Single-Pill, Triple Antihypertensive Therapy in Rural Sub-Saharan Africa: Preliminary Experience
Worldwide, arterial hypertension is the foremost preventable and modifiable cardiovascular risk factor. In addition to lif...
The Clear Value of Coronary Artery Calcification Evaluation on Non-Gated Chest Computed Tomography for Cardiac Risk Stratification
The Clear Value of Coronary Artery Calcification Evaluation on Non-Gated Chest Computed Tomography for Cardiac Risk Stratification
To enhance risk stratification in patients suspected of coronary artery disease, the assessment of coronary artery calcium...
Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?
Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?
Numerous genetic and epidemiologic studies have demonstrated an association between elevated levels of lipoprotein(a) (Lp[...
Automatic Quantification of Local Plaque Thickness Differences as Assessed by Serial Coronary Computed Tomography Angiography Using Scan-Quality-Based Vessel-Specific Thresholds
Automatic Quantification of Local Plaque Thickness Differences as Assessed by Serial Coronary Computed Tomography Angiography Using Scan-Quality-Based Vessel-Specific Thresholds
The use of serial coronary computed tomography angiography (CCTA) allows for the early assessment of coronary plaque progr...
Impact of Access Site on Periprocedural Bleeding and Cerebral and Coronary Events in High-Bleeding-Risk Percutaneous Coronary Intervention: Findings from the RIVA-PCI Trial
Impact of Access Site on Periprocedural Bleeding and Cerebral and Coronary Events in High-Bleeding-Risk Percutaneous Coronary Intervention: Findings from the RIVA-PCI Trial
The preference for using transradial access (TRA) over transfemoral access (TFA) in patients requiring percutaneous corona...
Dual-Pathway Inhibition with Rivaroxaban and Low-Dose Aspirin Does Not Alter Immune Cell Responsiveness and Distribution in Patients with Coronary Artery Disease
Dual-Pathway Inhibition with Rivaroxaban and Low-Dose Aspirin Does Not Alter Immune Cell Responsiveness and Distribution in Patients with Coronary Artery Disease
Cardiovascular diseases (CVD) are the leading cause of death globally. Inflammation is an important driver of CVD where ti...
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