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Macrophages enhance sodium channel expression in cardiomyocytes
Macrophages enhance sodium channel expression in cardiomyocytes
Cardiac macrophages facilitate electrical conduction through the atrioventricular-node (AV) in mice. A possible role for c...
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Ventricular fibrillation (VF)-induced cardiac arrest frequently complicates ST-segment elevation myocardial infarction (ST...
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis
Nuclear factor of activated T cells 5 (NFAT5) is an osmosensitive transcription factor that is well-studied in renal but r...
Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells
Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells
The heterogeneity of endothelial cells (ECs) across human tissues remains incompletely inventoried. We constructe...
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia
Propionic acidemia (PA), arising from PCCA or PCCB variants, manifests as life-threatening cardiomyopathy and arrhythmias,...
Oxidative stress initiates hemodynamic change in CKD-induced heart disease
Oxidative stress initiates hemodynamic change in CKD-induced heart disease
Chronic kidney disease (CKD) predisposes to cardiac remodeling and coronary microvascular dysfunction. Studies in swine id...
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
Numerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies....
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exp...
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (C...
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or atte...
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
CD40L–CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary...
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic str...
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolis...
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mor...
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinicall...
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct...
Cardioprotection in cardiovascular surgery
Cardioprotection in cardiovascular surgery
Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic inj...
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitocho...
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is inv...
Proprioceptors of the human pericardium
Proprioceptors of the human pericardium
In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a p...
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor (β3AR) agonists have been shown to protect against ischemia–reperfusion injury (IRI...
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Exercise is an effective way to alleviate breast cancer-induced cardiac injury to a certain extent. However, whether volun...
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immunotherapy represents an emergent and heterogeneous group of anticancer treatments harnessing the human immune-surveill...
Cardioprotection strategies for anthracycline cardiotoxicity
Cardioprotection strategies for anthracycline cardiotoxicity
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This succes...
Pathophysiology and clinical relevance of atrial myopathy
Pathophysiology and clinical relevance of atrial myopathy
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria...
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes
Recognizing that cells “feel” and respond to their mechanical environment, recent studies demonstrate that man...
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovasc...
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we que...
Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
The coronary perivascular adipose tissue (cPVAT) has been associated to the burden of cardiovascular risk factors and to t...
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmenta...
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