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First-in-human study of neuron regenerative therapy NNI-362 to evaluate the safety, pharmacokinetics, and pharmacodynamics in healthy aged population
First-in-human study of neuron regenerative therapy NNI-362 to evaluate the safety, pharmacokinetics, and pharmacodynamics in healthy aged population
A placebo-controlled, double-blind Phase 1a trial examined the safety, tolerability, and pharmacokinetics of NNI-362 as we...
Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups
Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) pathology. Recently, plasm...
Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis
Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis
Cerebral small vessel disease (CSVD) is a common neurological condition that contributes to strokes, dementia, disability,...
Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer’s disease
Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer’s disease
The gut microbiota may influence cognitive function via the gut-brain axis. This study aimed to investigate the gut microb...
Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia
Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia
A pathogenic variant in the NOTCH3 gene has been identified as the cause of cerebral autosomal dominant arteriopathy with ...
Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults
Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults
Accumulation of critically short telomeres (CST) is implicated in decreased tissular regenerative capacity and increased s...
Brain derived β-interferon is a potential player in Alzheimer’s disease pathogenesis and cognitive impairment
Brain derived β-interferon is a potential player in Alzheimer’s disease pathogenesis and cognitive impairment
Recent research has postulated that the activation of cGAS-STING-interferon signalling pathways could be implicated in the...
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer’s disease
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer’s disease
Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheim...
Anti-diabetic agents and the risks of dementia in patients with type 2 diabetes: a systematic review and network meta-analysis of observational studies and randomized controlled trials
Anti-diabetic agents and the risks of dementia in patients with type 2 diabetes: a systematic review and network meta-analysis of observational studies and randomized controlled trials
To evaluate the association between anti-diabetic agents and the risks of dementia in patients with type 2 diabetes (T2D)....
Retinal thickness predicts the risk of cognitive decline over five years
Retinal thickness predicts the risk of cognitive decline over five years
Dementia poses a significant burden on healthcare systems. Early identification of individuals at risk for cognitive decli...
Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity
Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity
As a currently incurable but preventable disease, the prevention and early diagnosis of Alzheimer’s disease (AD) has...
Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy
Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy
Posterior cortical atrophy (PCA) is a rare condition characterized by early-onset and progressive visual impairment. Indiv...
Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic
Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic
Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple ...
Cancer research provides a model for advancing clinical trials in dementia in the era of disease-modifying Alzheimer’s-type dementia therapies
Cancer research provides a model for advancing clinical trials in dementia in the era of disease-modifying Alzheimer’s-type dementia therapies
Dementia and cancer are multifactorial, widely-feared, age-associated clinical syndromes that are increasing in prevalence...
Association between glycemic status and all-cause mortality among individuals with dementia: a nationwide cohort study
Association between glycemic status and all-cause mortality among individuals with dementia: a nationwide cohort study
To examine the association between glycemic status and all-cause mortality risk among individuals with dementia. We enroll...
Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy
Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy
Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for react...
Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Early-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ ...
Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study
Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study
Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cogniti...
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review
Clinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biolog...
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amy...
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
Identifying individuals with mild cognitive impairment (MCI) who are likely to progress to Alzheimer’s disease and r...
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impair...
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
To estimate the perceived value of additional testing with amyloid-PET in Euros in healthy participants acting as analogue...
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. Howev...
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a funct...
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Cognitive complaints are often regarded as an early sign of Alzheimer’s disease (AD) but may also occur in several o...
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
There are increasing reports on the cognitive and emotional benefits of positive reminiscence therapy in older people. The...
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
Identification of patients with idiopathic normal pressure hydrocephalus (iNPH) in a collective with suspected neurodegene...
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumula...
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life (HR-QoL) is an important outcome for patients and crucial for demonstrating the value of ne...
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