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Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity
Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity
As a currently incurable but preventable disease, the prevention and early diagnosis of Alzheimer’s disease (AD) has...
Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy
Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy
Posterior cortical atrophy (PCA) is a rare condition characterized by early-onset and progressive visual impairment. Indiv...
Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic
Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic
Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple ...
Cancer research provides a model for advancing clinical trials in dementia in the era of disease-modifying Alzheimer’s-type dementia therapies
Cancer research provides a model for advancing clinical trials in dementia in the era of disease-modifying Alzheimer’s-type dementia therapies
Dementia and cancer are multifactorial, widely-feared, age-associated clinical syndromes that are increasing in prevalence...
Association between glycemic status and all-cause mortality among individuals with dementia: a nationwide cohort study
Association between glycemic status and all-cause mortality among individuals with dementia: a nationwide cohort study
To examine the association between glycemic status and all-cause mortality risk among individuals with dementia. We enroll...
Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy
Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy
Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for react...
Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea
Early-onset dementia (EOD, onset age < 65) and late-onset dementia (LOD, onset age ≥ ...
Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study
Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study
Given the rising awareness of health-related lifestyle modifications, the impact of changes in body weight (BW) on cogniti...
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review
Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review
Clinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biolog...
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amy...
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
The age-specific comorbidity burden of mild cognitive impairment: a US claims database study
Identifying individuals with mild cognitive impairment (MCI) who are likely to progress to Alzheimer’s disease and r...
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impair...
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
How healthy participants value additional diagnostic testing with amyloid-PET in patients diagnosed with mild cognitive impairment — a bidding game experiment
To estimate the perceived value of additional testing with amyloid-PET in Euros in healthy participants acting as analogue...
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Clinical outcomes up to 9 years after [18F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. Howev...
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials
Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a funct...
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories
Cognitive complaints are often regarded as an early sign of Alzheimer’s disease (AD) but may also occur in several o...
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
Cross-cultural effects of reminiscence therapy on life satisfaction and autobiographical memory of older adults: a pilot study across Mexico and Spain
There are increasing reports on the cognitive and emotional benefits of positive reminiscence therapy in older people. The...
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
The metabolic spatial covariance pattern of definite idiopathic normal pressure hydrocephalus: an FDG PET study with principal components analysis
Identification of patients with idiopathic normal pressure hydrocephalus (iNPH) in a collective with suspected neurodegene...
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumula...
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life in subjective cognitive decline and mild cognitive impairment: a longitudinal cohort analysis
Health-related quality of life (HR-QoL) is an important outcome for patients and crucial for demonstrating the value of ne...
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
The Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare...
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Distinct effects of cholesterol profile components on amyloid and vascular burdens
Cholesterol plays important roles in β-amyloid (Aβ) metabolism and atherosclerosis. However, the relationships o...
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults
Genomic study of cognition decline while considering baseline cognition and lifestyle behaviors is scarce. We aimed to eva...
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Subjective cognitive complaints and blood biomarkers of neurodegenerative diseases: a longitudinal cohort study
Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease in memory clini...
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
Understanding the pathological characteristics of various mild cognitive impairment (MCI) subtypes is crucial for the diff...
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up ...
Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial
Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial
In MAPT (Multidomain Alzheimer Preventive Trial), a cognitive effect of multidomain intervention (MI) was showed in non-de...
Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials
Longitudinal resting-state EEG in amyloid-positive patients along the Alzheimer’s disease continuum: considerations for clinical trials
To enable successful inclusion of electroencephalography (EEG) outcome measures in Alzheimer’s disease (AD) clinical...
Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Correction: Differential response to donepezil in MRI subtypes of mild cognitive impairment
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease
Mild cognitive impairment (MCI) is often considered an early stage of dementia, with estimated rates of progression to dem...
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