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ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1
Investigating whether the circadian rhythm coregulator BMAL1 mediates the anti-osteoporotic effect of ED-71 in T2DM and it...
Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1 [Letter]
Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1 [Letter]
Letter for the article Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling...
Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in Laparoscopic Surgery [Letter]
Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in Laparoscopic Surgery [Letter]
Letter for the article Effects of Propofol, Low and High Doses of Remimazolam on Hemodynamic and Inflammatory Response in ...
Semaglutide Alleviates Ovary Inflammation via the AMPK/SIRT1/NF‑κB Signaling Pathway in Polycystic Ovary Syndrome Mice
Semaglutide Alleviates Ovary Inflammation via the AMPK/SIRT1/NF‑κB Signaling Pathway in Polycystic Ovary Syndrome Mice
This study investigated whether semaglutide, a novel GLP-1 RA, could alleviate ovarian inflammation in PCOS mice.
Clinical Utility of Rilonacept for the Treatment of Recurrent Pericarditis: Design, Development, and Place in Therapy
Clinical Utility of Rilonacept for the Treatment of Recurrent Pericarditis: Design, Development, and Place in Therapy
We discuss the rationale for the use of rilonacept, specific clinical indications and distinct features, pros and cons, ga...
Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial
Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial
Demonstrating the efficacy and safety of general anesthesia induction with ciprofol in hip fracture surgery of elderly pat...
Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis
Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis
Exploring novel molecular interplay of long noncoding RNA CBR3-AS1/ miRNA-29/ FIZZ1 axis in moderating the inflammatory pr...
Current Perspectives on Letermovir and Maribavir for the Management of Cytomegalovirus Infection in Solid Organ Transplant Recipients
Current Perspectives on Letermovir and Maribavir for the Management of Cytomegalovirus Infection in Solid Organ Transplant Recipients
Providing a comprehensive review of the clinical data supporting the use of letermovir and maribavir in clinical practice....
Untargeted Lipidomics Analysis to Discover Lipid Profiles and Biomarkers of Rabbit Acne Model and Reveal Action Mechanism of Isotretinoin
Untargeted Lipidomics Analysis to Discover Lipid Profiles and Biomarkers of Rabbit Acne Model and Reveal Action Mechanism of Isotretinoin
Discovering lipid profiles and biomarkers of the rabbit ear acne model, and investigating the mechanism of isotretinoin in...
Ciprofol in Children Undergoing Adenoidectomy and Adenotonsillectomy: A Retrospective Cohort Study
Ciprofol in Children Undergoing Adenoidectomy and Adenotonsillectomy: A Retrospective Cohort Study
Evaluating the safety and effectiveness of ciprofol in general anesthesia for children undergoing adenoidectomy and adenot...
Metformin’s Enigma: Bridging Gaps in Research on Potential Benefits & Associated Risks - A Critical Plea for Comprehensive Investigation [Response to Letter]
Metformin’s Enigma: Bridging Gaps in Research on Potential Benefits & Associated Risks - A Critical Plea for Comprehensive Investigation [Response to Letter]
Response to Letter in regards to Metformin’s Enigma: Bridging Gaps in Research on Potential Benefits & A...
Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease
Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease
Evaluating the effect and mechanism of the Qushi Huatan decoction against coronary heart disease through network pharmacol...
Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study
Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study
Analyzing and summarize the current status of the known relationship between AKI and mitochondria, providing references an...
Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation
Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation
To discover potential IH-associated therapeutics through a transcriptomic, computational drug repurposing methodology. Rea...
Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms, Clinical Management and Innovative Treatment
Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms, Clinical Management and Innovative Treatment
Discussing the current status of anticancer drug-induced cardiotoxicity in terms of the pathogenesis and treatment with a ...
Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Response to Letter]
Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Response to Letter]
Response to Letter in regards to Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blin...
Huangqi-Danshen Decoction Against Renal Fibrosis in UUO Mice via TGF-β1 Induced Downstream Signaling Pathway
Huangqi-Danshen Decoction Against Renal Fibrosis in UUO Mice via TGF-β1 Induced Downstream Signaling Pathway
To uncover the underlying mechanism of HDD antagonizing renal fibrosis through NP analysis and experimental validation. Re...
Feasibility and Safety of PD-1 Blockades Among Elderly Patients with Metastatic Esophageal Squamous Cell Carcinoma: A Real-World Study
Feasibility and Safety of PD-1 Blockades Among Elderly Patients with Metastatic Esophageal Squamous Cell Carcinoma: A Real-World Study
To identify the effectiveness and safety of PD-1 blockades among elderly patients with metastatic esophageal squamous cell...
Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning
Revisiting Niclosamide Formulation Approaches – a Pathway Toward Drug Repositioning
Endeavors made to enhance the water solubility & consequently the bioavailability of NIC, considering various formulat...
Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization
Guanxinning Tablet Alleviates Post-Ischemic Stroke Injury Via Regulating Complement and Coagulation Cascades Pathway and Inflammatory Network Mobilization
GXNT intervention exerts a beneficial effect against post-IS injury via regulating complement & coagulation cascades p...
Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron
Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron
Determining the dose-response of phenylephrine to prevent SIH in cesarean delivery when 4 mg of ondansetron was used as a ...
Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
We explore various nanoscale drug delivery systems (NDDSs), including lipid-based, polymer-based, nanoemulsions, nanogels,...
Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease [Letter]
Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease [Letter]
Letter for the article Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of...
Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway
Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway
Investigating whether NDSP exerts its protective effects against I/R injury by regulating ferroptosis and aimed to elucida...
Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy: A Randomized Controlled Trial [Letter]
Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy: A Randomized Controlled Trial [Letter]
Letter for the article Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopi...
ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis
ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis
Investigating whether EphrinB2-EphB4 and RANKL/RANK/OPG signaling cooperate in mediating the process of osteoporosis by ED...
A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK
A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK
Evaluating the role of a novel chalcone derivative of tetramethylpyrazine (HCTMPPK) in lung adenocarcinoma and showing HCT...
A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds
A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds
Both in vitro and in silico studies were performed to determine the potential of these heterocyclic compounds in the fight...
Comparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation
Comparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation
This study of 65 years or older inpatients with Atrial Fibrillation to compare clinical adverse outcomes between generic a...
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis
RAR inhibited extracellular matrix (ECM) degradation and oxidative stress response via the MAPK signaling pathway in KOA, ...
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