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Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Until recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-...
Natural-derived acetophenones: chemistry and pharmacological activities
Natural-derived acetophenones: chemistry and pharmacological activities
Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains...
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successful...
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subt...
Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)
Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)
Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most v...
Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
N-Hydroxyapiosporamide (N-hydap), a marine product derived from a sponge-associated fungus, has shown promising inhibitory...
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy
New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy
Four extracts of the marine-derived fungus Penicillium velutinum J.F.H. Beyma were obtained via metal ions stress conditio...
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells
Cancer cells generally exhibit ‘iron addiction’ phenotypes, which contribute to their vulnerability to ferropt...
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration
Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration
The generation of chemically engineered essential oils (CEEOs) prepared from bi-heteroatomic reactions using ammonium thio...
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway
Adenosma buchneroides Bonati, also known as fleagrass, is an important medicinal plant used by the Akha (Hani) people of C...
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and i...
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
The marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA, ITS re...
5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
Alzheimer’s disease (AD) is a complex neurodegenerative condition. 5α-epoxyalantolactone (5α-EAL), a eudes...
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Plants and microbes are closely associated with each other in their ecological niches. Much has been studied about plant&#...
Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo
Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo
In this study, the effects of sea buckthorn oil (SBO), fish oil (FO) and an enzymatically synthesized structured lipid (SL...
Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations
Ulcerative colitis (UC) is a recurring autoimmune disorder characterized by persistent inflammation in the mucosal lining ...
Correction: Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Correction: Metabolism characterization and toxicity of N-hydap, a marine candidate drug for lung cancer therapy by LC–MS method
Following publication of the original article [1], the authors reported that the original version of this article unfortun...
Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Xiaoyankangjun tablet alleviates dextran sulfate sodium-induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Xiaoyankangjun tablet (XYKJP) is a traditional Chinese medicine formulation used to treat intestinal disorders in clinical...
Silvaticusins A–D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus
Silvaticusins A–D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus
Three new ent-kaurane diterpenoids, silvaticusins A–C (1–3), along with a new ent-kaurane dimer silvaticusin D...
Koningipyridines A and B, two nitrogen-containing polyketides from the fungus Trichoderma koningiopsis SC-5
Koningipyridines A and B, two nitrogen-containing polyketides from the fungus Trichoderma koningiopsis SC-5
Two novel koninginin derivatives, koningipyridines A and B (1 and 2), along with four known compounds (3˗6) were isol...
Precision enzyme discovery through targeted mining of metagenomic data
Precision enzyme discovery through targeted mining of metagenomic data
Metagenomics has opened new avenues for exploring the genetic potential of uncultured microorganisms, which may s...
Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins
Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins
Saffron has many pharmacological properties in addition to being a frequently used food seasoning. Crocin and picrocrocin ...
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction...
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natur...
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake...
Natural and engineered xylosyl products from microbial source
Natural and engineered xylosyl products from microbial source
Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural di...
Chemistry and biology of marine-derived Trichoderma metabolites
Chemistry and biology of marine-derived Trichoderma metabolites
Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with va...
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
A type of high molecular weight bioactive polymers called exopolysaccharides (EPS) are produced by thermophiles, the extre...
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 mi...
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, ...
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