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Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders
Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders
Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The cont...
The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study
The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study
Early detection of lifestyle factors, skin and hair color, circulating parameters, and metabolic comorbidities is crucial ...
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach
Muscle atrophy caused by denervation is common in neuromuscular diseases, leading to loss of muscle mass and function. How...
Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction
Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction
Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and a bl...
A strategy to pioneer key agent(s) in Cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology
A strategy to pioneer key agent(s) in Cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology
Over the past few decades, Cephalotaxus alkaloids (CAs) have been considered as significant natural agents with their intr...
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury
The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (...
Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukoc...
Predicting long-term progression of Alzheimer’s disease using a multimodal deep learning model incorporating interaction effects
Predicting long-term progression of Alzheimer’s disease using a multimodal deep learning model incorporating interaction effects
Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer’s disease (AD) prov...
The role of AMPK in macrophage metabolism, function and polarisation
The role of AMPK in macrophage metabolism, function and polarisation
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays ...
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Gout pain seriously affects the quality of patients' life. There is still no effective treatment. The inflammatory res...
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable soci...
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive int...
Preliminary analysis of immune-related markers in thymic carcinoid
Preliminary analysis of immune-related markers in thymic carcinoid
The immune-related microenvironment of thymic carcinoid has rarely been reported. We analyzed the expression of PD-L1 and ...
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications
Osteoporosis is currently the most prevalent bone disorder worldwide and is characterized by low bone mineral density and ...
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
The role of cholesterol metabolism in gastric cancer (GC) and its implications for tumor characteristics and immunotherapy...
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. E...
Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumu...
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Sepsis-caused multi-organ failure remains the major cause of morbidity and mortality in intensive care units with limited ...
Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway
Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway
Advanced prostate cancer (PCa) will develop into castration-resistant prostate cancer (CRPC) and lead to poor prognosis. A...
GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a hypoxic microenvironment, a high rate of heterogeneity as we...
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) has impacted approximately 390 million people worldwide and the morbidity is ...
Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes
Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes
Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological cha...
Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort
Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort
Pancreatic cancer is a lethal disease with a high mortality rate. The difficulty of early diagnosis is one of its primary ...
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good ...
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid...
The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis
The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis
ATM and ATR are two critical factors to regulate DNA damage response (DDR), and their mutations were frequently observed i...
A comparative study on ctDNA and tumor DNA mutations in lung cancer and benign cases with a high number of CTCs and CTECs
A comparative study on ctDNA and tumor DNA mutations in lung cancer and benign cases with a high number of CTCs and CTECs
Liquid biopsy provides a non-invasive approach that enables detecting circulating tumor DNA (ctDNA) and circulating tumor ...
TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma
TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma
Although the molecular features of pancreatic ductal adenocarcinoma (PDAC) have been well described, the impact of detaile...
Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells
Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells
Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC...
A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases
A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases
Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previ...
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