Pinsky PF, Parnes H. Screening for prostate cancer. N Engl J Med. 2023;388(15):1405–14.

Article  PubMed  Google Scholar 

Seibert TM, Garraway IP, Plym A, Mahal BA, Giri V, Jacobs MF, Cheng HH, Loeb S, Helfand BT, Eeles RA, Morgan TM. Genetic risk prediction for prostate cancer: implications for early detection and prevention. Eur Urol. 2023;83(3):241–8.

Article  CAS  PubMed  Google Scholar 

Desai K, McManus JM, Sharifi N. Hormonal therapy for prostate cancer. Endocr Rev. 2021;42(3):354–73.

Article  PubMed  PubMed Central  Google Scholar 

Shafi AA, Yen AE, Weigel NL. Androgen receptors in hormone-dependent and castration-resistant prostate cancer. Pharmacol Ther. 2013;140(3):223–38.

Article  CAS  PubMed  Google Scholar 

Labrecque MP, Coleman IM, Brown LG, True LD, Kollath L, Lakely B, Nguyen HM, Yang YC, da Costa RMG, Kaipainen A, Coleman R, Higano CS, Yu EY, Cheng HH, Mostaghel EA, Montgomery B, Schweizer MT, Hsieh AC, Lin DW, Corey E, Nelson PS, Morrissey C. Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer. J Clin Invest. 2019;129(10):4492–505.

Article  PubMed  PubMed Central  Google Scholar 

Ge R, Wang Z, Montironi R, Jiang Z, Cheng M, Santoni M, Huang K, Massari F, Lu X, Cimadamore A, Lopez-Beltran A, Cheng L. Epigenetic modulations and lineage plasticity in advanced prostate cancer. Ann Oncol. 2020;31(4):470–9.

Article  CAS  PubMed  Google Scholar 

Wang KC, Chang HY. Epigenomics: technologies and applications. Circ Res. 2018;122(9):1191–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang F, Xu D, Wang S, Wong CK, Martinez-Fundichely A, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, de Stanchina E, Berger MF, Gopalan A, Dow LE, Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y, Khurana E. Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science. 2022;376(6596): eabe1505.

Article  Google Scholar 

Teng M, Zhou S, Cai C, Lupien M, He HH. Pioneer of prostate cancer: past, present and the future of FOXA1. Protein Cell. 2021;12(1):29–38.

Article  CAS  PubMed  Google Scholar 

Chen F, Xiong W, Dou K, Ran Q. Knockdown of FOXK1 suppresses proliferation, migration, and invasion in prostate cancer cells. Oncol Res. 2017;25(8):1261–7.

Article  PubMed  PubMed Central  Google Scholar 

Rodriguez-Bravo V, Carceles-Cordon M, Hoshida Y, Cordon-Cardo C, Galsky MD, Domingo-Domenech J. The role of GATA2 in lethal prostate cancer aggressiveness. Nat Rev Urol. 2017;14(1):38–48.

Article  CAS  PubMed  Google Scholar 

Luo Z, Rhie SK, Lay FD, Farnham PJ. A prostate cancer risk element functions as a repressive loop that regulates HOXA13. Cell Rep. 2017;21(6):1411–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paranjape AN, Soundararajan R, Werden SJ, Joseph R, Taube JH, Liu H, Rodriguez-Canales J, Sphyris N, Wistuba I, Miura N, Dhillon J, Mahajan N, Mahajan K, Chang JT, Ittmann M, Maity SN, Logothetis C, Tang DG, Mani SA. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties. Oncogene. 2016;35(46):5963–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv S, Wen H, Shan X, Li J, Wu Y, Yu X, Huang W, Wei Q. Loss of KMT2D induces prostate cancer ROS-mediated DNA damage by suppressing the enhancer activity and DNA binding of antioxidant transcription factor FOXO3. Epigenetics. 2019;14(12):1194–208.

Article  PubMed  PubMed Central  Google Scholar 

Lu X, Fong KW, Gritsina G, Wang F, Baca SC, Brea LT, Berchuck JE, Spisak S, Ross J, Morrissey C, Corey E, Chandel NS, Catalona WJ, Yang X, Freedman ML, Zhao JC, Yu J. HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer. Nat Genet. 2022;54(5):670–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu L, Yi B, Wei S, Rao D, He Y, Naik G, Bae S, Liu XM, Yang WH, Sonpavde G, Liu R, Wang L. Loss of FOXP3 and TSC1 accelerates prostate cancer progression through synergistic transcriptional and posttranslational regulation of c-MYC. Cancer Res. 2019;79(7):1413–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu W, Sun J, Zhou H, Wang F, Zhao C, Li K, Fan C, Ding G, Wang J. HNF1B inhibits cell proliferation via repression of SMAD6 expression in prostate cancer. J Cell Mol Med. 2020;24(24):14539–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kao KC, Vilbois S, Tsai CH, Ho PC. Metabolic communication in the tumour-immune microenvironment. Nat Cell Biol. 2022;24(11):1574–83.

Article  CAS  PubMed  Google Scholar 

Khalaf K, Hana D, Chou JT, Singh C, Mackiewicz A, Kaczmarek M. Aspects of the tumor microenvironment involved in immune resistance and drug resistance. Front Immunol. 2021;12: 656364.

Article  PubMed  PubMed Central  Google Scholar 

Fan J, To KKW, Chen ZS, Fu L. ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance. Drug Resist Updat. 2023;66: 100905.

Article  CAS  PubMed  Google Scholar 

Huang X, Wang L, Guo H, Zhang W, Shao Z. Single-cell transcriptomics reveals the regulative roles of cancer associated fibroblasts in tumor immune microenvironment of recurrent osteosarcoma. Theranostics. 2022;12(13):5877–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labbé DP, Brown M. transcriptional regulation in prostate cancer. Cold Spring Harb Perspect Med. 2018;8(11): a030437.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Li W, Zhao Y, Kang D, Fu W, Zheng X, Pang X, Du G. Members of FOX family could be drug targets of cancers. Pharmacol Ther. 2018;181:183–96.

Article  CAS  PubMed  Google Scholar 

Mallo M, Wellik DM, Deschamps J. Hox genes and regional patterning of the vertebrate body plan. Dev Biol. 2010;344(1):7–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rezsohazy R, Saurin AJ, Maurel-Zaffran C, Graba Y. Cellular and molecular insights into Hox protein action. Development. 2015;142(7):1212–27.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Peng J, Li B, Wang Z, Wang H, Wang Y, Hong L. HOXA1 promotes aerobic glycolysis and cancer progression in cervical cancer. Cell Signal. 2023;109: 110747.

Article  CAS  PubMed  Google Scholar 

Cui M, Chen M, Shen Z, Wang R, Fang X, Song B. LncRNA-UCA1 modulates progression of colon cancer through regulating the miR-28-5p/HOXB3 axis. J Cell Biochem. 2019;120(5):6926–36.

Article  CAS  PubMed  Google Scholar 

Li HM, Yu YK, Liu Q, Wei XF, Zhang J, Zhang RX, Sun HB, Wang ZF, Xing WQ, Li Y. LncRNA SNHG1 regulates the progression of esophageal squamous cell cancer by the miR-204/HOXC8 Axis. Onco Targets Ther. 2020;13:757–67.

Article  PubMed  PubMed Central  Google Scholar 

Komisarof J, McCall M, Newman L, Bshara W, Mohler JL, Morrison C, Land H. A four gene signature predictive of recurrent prostate cancer. Oncotarget. 2017;8(2):3430–40.

Article  PubMed  Google Scholar 

Li C, Cui J, Zou L, Zhu L, Wei W. Bioinformatics analysis of the expression of HOXC13 and its role in the prognosis of breast cancer. Oncol Lett. 2020;19(1):899–907.

CAS  PubMed  Google Scholar 

Yu M, Yu S, Zhou W, Yi B, Liu Y. HOXC6/8/10/13 predict poor prognosis and associate with immune infiltrations in glioblastoma. Int Immunopharmacol. 2021;101(Pt A): 108293.

Article  CAS  PubMed  Google Scholar 

Liu B, Li J, Li JM, Liu GY, Wang YS. HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene. Cell Cycle. 2021;20(2):236–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai M, Song J, Wang L, Zhou K, Shu L. HOXC13 promotes cervical cancer proliferation, invasion and Warburg effect through β-catenin/c-Myc signaling pathway. J Bioenerg Biomembr. 2021;53(5):597–608.

Article  CAS  PubMed  Google Scholar 

Zhou T, Fu H, Dong B, Dai L, Yang Y, Yan W, Shen L. HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair. Thorac Cancer. 2020;11(11):3071–85.

Article  CAS  PubMed  Google Scholar 

Riederer S, Del Canizo A, Navas J,