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Oral corticosteroids for cystic fibrosis pulmonary exacerbation: seeking the future in the past
Oral corticosteroids for cystic fibrosis pulmonary exacerbation: seeking the future in the past
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Reply to: Steroids in cystic fibrosis exacerbations: are we picking the right patients?
Reply to: Steroids in cystic fibrosis exacerbations: are we picking the right patients?
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Local receptor-interacting protein kinase 2 inhibition mitigates house dust mite-induced asthma
Local receptor-interacting protein kinase 2 inhibition mitigates house dust mite-induced asthma
Graphical abstractMain findings of the study. Intranasal therapeutic administration of receptor-interacting serine/threoni...
Efficacy and safety of selexipag in patients with inoperable or persistent/recurrent CTEPH (SELECT randomised trial)
Efficacy and safety of selexipag in patients with inoperable or persistent/recurrent CTEPH (SELECT randomised trial)
Graphical abstractOverview of the study. #: patients were stratified by baseline treatment with pulmonary hypertension (PH...
Salivary polyreactive antibodies and Haemophilus influenzae are associated with respiratory infection severity in young children with recurrent respiratory infections
Salivary polyreactive antibodies and Haemophilus influenzae are associated with respiratory infection severity in young children with recurrent respiratory infections
IntroductionRecurrent respiratory tract infections (rRTIs) affect 10–15% of young children [1, 2] and increase the risk of...
Deep phenotyping of unaffected carriers of pathogenic BMPR2 variants screened for pulmonary arterial hypertension
Deep phenotyping of unaffected carriers of pathogenic BMPR2 variants screened for pulmonary arterial hypertension
AbstractIntroduction Pathogenic variants in the gene encoding for BMPR2 are a major genetic risk factor for heritable pulm...
Optimisation of detecting chronic thromboembolic pulmonary hypertension in acute pulmonary embolism survivors: the InShape IV study
Optimisation of detecting chronic thromboembolic pulmonary hypertension in acute pulmonary embolism survivors: the InShape IV study
Conflict of interest: S. Barco received research support from Boston Scientific, Medtronic, Concept Medical, Sanofi and No...
Reply to: Oral corticosteroids for cystic fibrosis pulmonary exacerbation: seeking the future in the past
Reply to: Oral corticosteroids for cystic fibrosis pulmonary exacerbation: seeking the future in the past
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Bronchoconstriction with inhaled ATP in healthy volunteers
Bronchoconstriction with inhaled ATP in healthy volunteers
To the Editor:P2X3 receptors are found on sensory nerves and are activated by ATP. The recent discovery that P2X3 antagoni...
Exacerbation history and blood eosinophil count prior to diagnosis of COPD and risk of subsequent exacerbations
Exacerbation history and blood eosinophil count prior to diagnosis of COPD and risk of subsequent exacerbations
IntroductionReducing the risk of exacerbations is a key objective of COPD management [1] given the substantial evidence ab...
Steroids in cystic fibrosis exacerbations: are we picking the right patients?
Steroids in cystic fibrosis exacerbations: are we picking the right patients?
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What to do when pulmonary arterial hypertension screening suggests neither fish nor fowl? The DOLPHIN-GENESIS study
What to do when pulmonary arterial hypertension screening suggests neither fish nor fowl? The DOLPHIN-GENESIS study
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RIPK2 inhibition gets the NOD for asthma
RIPK2 inhibition gets the NOD for asthma
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Salivary polyreactive antibodies, airway bacteria, and recurrent respiratory infection severity
Salivary polyreactive antibodies, airway bacteria, and recurrent respiratory infection severity
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Selexipag: still looking for its place
Selexipag: still looking for its place
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Previous exacerbations in newly diagnosed COPD patients: do they matter?
Previous exacerbations in newly diagnosed COPD patients: do they matter?
Shareable abstractThe new GOLD document proposes that newly diagnosed COPD patients could benefit from triple inhaled ther...
Reversible carfilzomib-induced pulmonary arterial hypertension: don't take your eyes off the ball!
Reversible carfilzomib-induced pulmonary arterial hypertension: don't take your eyes off the ball!
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A range of 30-62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance
A range of 30-62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance
Graphical AbstractOverview of the study. PCD: primary ciliary dyskinesia; FEV1: forced expiratory volume in 1 s; ODA: oute...
How many functioning ciliated airway epithelial cells are necessary for effective mucociliary clearance?
How many functioning ciliated airway epithelial cells are necessary for effective mucociliary clearance?
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TARGETing the utility of CT-guided pleural biopsy facilitated by PET-CT imaging
TARGETing the utility of CT-guided pleural biopsy facilitated by PET-CT imaging
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Reply to: ERS/ATS spirometry interpretation standards: a gap in grading severity of airflow obstruction
Reply to: ERS/ATS spirometry interpretation standards: a gap in grading severity of airflow obstruction
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Nintedanib and symptoms of fibrotic lung disease: a glimmer of hope for patients living with pulmonary fibrosis
Nintedanib and symptoms of fibrotic lung disease: a glimmer of hope for patients living with pulmonary fibrosis
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Indwelling pleural catheters or chest drains for managing malignant pleural effusions: a distinction without a difference?
Indwelling pleural catheters or chest drains for managing malignant pleural effusions: a distinction without a difference?
ExtractIn patients with symptomatic malignant pleural effusion (MPE), definitive effusion management is traditionally achi...
Fibroblast heterogeneity in pulmonary fibrosis: a new target for therapeutics development?
Fibroblast heterogeneity in pulmonary fibrosis: a new target for therapeutics development?
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The impact of outpatient versus inpatient management on health-related quality of life outcomes for patients with malignant pleural effusion: the OPTIMUM randomised clinical trial
The impact of outpatient versus inpatient management on health-related quality of life outcomes for patients with malignant pleural effusion: the OPTIMUM randomised clinical trial
Parthipan Sivakumar, Deirdre B. Fitzgerald, Hugh Ip, Deepak Rao, Alex West, Farinaz Noorzad, De...
Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts
Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts
IntroductionExtracellular matrix (ECM)-producing myofibroblasts are a key therapeutic target to combat tissue fibrosis, on...
Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement
Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement
AbstractThis statement outlines a review of the literature and current practice concerning the prevalence, clinical signif...
Understanding the clinical implications of the "non-classical" microbiome in chronic lung disease: a viewpoint
Understanding the clinical implications of the "non-classical" microbiome in chronic lung disease: a viewpoint
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Diminished airway host innate response in people with cystic fibrosis who experience frequent pulmonary exacerbations
Diminished airway host innate response in people with cystic fibrosis who experience frequent pulmonary exacerbations
IntroductionCystic fibrosis (CF) pulmonary exacerbations are important clinical events for people with CF, that alter the ...
Travel-acquired paediatric tuberculosis in the Greater Toronto Area, Canada, 2002-2018
Travel-acquired paediatric tuberculosis in the Greater Toronto Area, Canada, 2002-2018
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