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Pembrolizumab for the First-Line Treatment of Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma: Results from the Single-Arm, Open-Label, Phase III KEYNOTE-913 Study
Pembrolizumab for the First-Line Treatment of Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma: Results from the Single-Arm, Open-Label, Phase III KEYNOTE-913 Study
The phase III KEYNOTE-913 study was conducted to evaluate the efficacy and safety of pembrolizumab as first-line therapy i...
A Practice Approach to Acne Fulminans in Adolescents
A Practice Approach to Acne Fulminans in Adolescents
Acne fulminans (AF) is a severe form of inflammatory acne commonly associated with adolescents. It is characterized by an ...
KECORT Study: An International e-Delphi Study on the Treatment of KEloids Using Intralesional CORTicosteroids in Clinical Practice
KECORT Study: An International e-Delphi Study on the Treatment of KEloids Using Intralesional CORTicosteroids in Clinical Practice
Intralesional corticosteroid administration (ICA) is a first-line keloid treatment. However, it faces significant variabil...
Managing Urticarial Vasculitis: A Clinical Decision-Making Algorithm Based on Expert Consensus
Managing Urticarial Vasculitis: A Clinical Decision-Making Algorithm Based on Expert Consensus
Urticarial vasculitis (UV) is a rare and difficult-to-treat, small-vessel leukocytoclastic vasculitis presenting with recu...
Intravenous Immunoglobulin Therapy for Pyoderma Gangrenosum: A Multicenter Retrospective Analysis in 81 Patients
Intravenous Immunoglobulin Therapy for Pyoderma Gangrenosum: A Multicenter Retrospective Analysis in 81 Patients
Pyoderma gangrenosum (PG) is rare neutrophil skin disease causing painful, progressively enlarging ulcers. Among the treat...
Ruxolitinib Cream Monotherapy Improved Symptoms and Quality of Life in Adults and Adolescents with Mild-to-Moderate Atopic Dermatitis: Patient-Reported Outcomes from Two Phase III Studies
Ruxolitinib Cream Monotherapy Improved Symptoms and Quality of Life in Adults and Adolescents with Mild-to-Moderate Atopic Dermatitis: Patient-Reported Outcomes from Two Phase III Studies
Atopic dermatitis (AD) is associated with itch, skin pain, sleep disturbances, and diminished quality of life (QoL). Ruxol...
Multiple Keratoacanthomas Associated with Genetic Syndromes: Narrative Review and Proposal of a Diagnostic Algorithm
Multiple Keratoacanthomas Associated with Genetic Syndromes: Narrative Review and Proposal of a Diagnostic Algorithm
Keratoacanthoma (KA) is a relatively common, fast-growing epithelial tumour, with characteristic behaviour and clinical va...
Overcoming Resistance Mechanisms to Melanoma Immunotherapy
Overcoming Resistance Mechanisms to Melanoma Immunotherapy
The advent of immune checkpoint inhibition has revolutionized treatment of advanced melanoma. While most patients derive s...
Frontal Fibrosing Alopecia: An Update
Frontal Fibrosing Alopecia: An Update
In this review, we discuss recent developments in our understanding of frontal fibrosing alopecia, a disease that has beco...
Prognostic Biomarkers in Evolving Melanoma Immunotherapy
Prognostic Biomarkers in Evolving Melanoma Immunotherapy
Melanoma, a highly aggressive form of skin cancer, has seen significant advancements in treatment through the introduction...
Human Inborn Errors of Immunity in Pyoderma Gangrenosum: A Systematic Review
Human Inborn Errors of Immunity in Pyoderma Gangrenosum: A Systematic Review
Pyoderma gangrenosum (PG) is a rare ulcerative neutrophilic dermatosis that can be associated with primary immunodeficienc...
Switching to Interleukin-23 Inhibitors After Ineffectiveness of Ustekinumab: Evaluating Real-World Outcomes in Psoriasis Treatment
Switching to Interleukin-23 Inhibitors After Ineffectiveness of Ustekinumab: Evaluating Real-World Outcomes in Psoriasis Treatment
Funding This study was supported by The University Medical ...
Adherence to Hidradenitis Suppurativa Treatment
Adherence to Hidradenitis Suppurativa Treatment
Hidradenitis suppurativa (HS) is a chronic, debilitating skin condition that requires multimodal treatment. Adherence rema...
Efficacy, Safety, and Long-Term Disease Control of Ruxolitinib Cream Among Adolescents with Atopic Dermatitis: Pooled Results from Two Randomized Phase 3 Studies
Efficacy, Safety, and Long-Term Disease Control of Ruxolitinib Cream Among Adolescents with Atopic Dermatitis: Pooled Results from Two Randomized Phase 3 Studies
Atopic dermatitis (AD), a highly pruritic, inflammatory skin disease, affects approximately 7% of adolescents globally. A ...
Management and Long-Term Outcomes of Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) in Children: A Scoping Review
Management and Long-Term Outcomes of Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) in Children: A Scoping Review
Drug reaction with eosinophilia and systemic symptoms (DReSS) is known to cause mortality and long-term sequelae in the pe...
Approach to the Atypical Wound
Approach to the Atypical Wound
The heterogeneity of atypical wounds can present diagnostic and therapeutic challenges; however, as the prevalence of atyp...
Efficacy and Safety of Brodalumab, an Anti-interleukin-17 Receptor A Monoclonal Antibody, for Palmoplantar Pustulosis: 16-Week Results of a Randomized Clinical Trial
Efficacy and Safety of Brodalumab, an Anti-interleukin-17 Receptor A Monoclonal Antibody, for Palmoplantar Pustulosis: 16-Week Results of a Randomized Clinical Trial
Palmoplantar pustulosis (PPP), a refractory skin disease characterized by repeated eruptions of sterile pustules and vesic...
Pityriasis Rubra Pilaris: An Updated Review of Clinical Presentation, Etiopathogenesis, and Treatment Options
Pityriasis Rubra Pilaris: An Updated Review of Clinical Presentation, Etiopathogenesis, and Treatment Options
Pityriasis rubra pilaris (PRP) is a rare papulosquamous reaction pattern with a significant impact on quality of life. Typ...
Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program
Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program
The ALLEGRO phase 2a and 2b/3 studies demonstrated that ritlecitinib, an oral JAK3/TEC family kinase inhibitor, is efficac...
Mucocutaneous Manifestations of Recreational Drug Use
Mucocutaneous Manifestations of Recreational Drug Use
Recreational drug use is increasingly common in the dermatology patient population and is often associated with both gener...
The Skin Microbiome and its Significance for Dermatologists
The Skin Microbiome and its Significance for Dermatologists
The skin is a physical and immunological barrier to the external environment. Its large surface area is colonized by diver...
Pressure and Skin: A Review of Disease Entities Driven or Influenced by Mechanical Pressure
Pressure and Skin: A Review of Disease Entities Driven or Influenced by Mechanical Pressure
Skin perceives and reacts to external mechanical forces to create resistance against the external environment. Excessive o...
Recent Advances in Treatment of Systemic Sclerosis and Morphea
Recent Advances in Treatment of Systemic Sclerosis and Morphea
Systemic sclerosis (SSc) and morphea are autoimmune sclerosing diseases that cause significant morbidity, and in the case ...
Small-Molecule Inhibitors and Biologics for Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Network Meta-Analysis
Small-Molecule Inhibitors and Biologics for Palmoplantar Psoriasis and Palmoplantar Pustulosis: A Systematic Review and Network Meta-Analysis
The comparative efficacy of biologics and small-molecule inhibitors in treating palmoplantar psoriasis (PP) and palmoplant...
Expert Panel Review of Skin and Hair Dermatophytoses in an Era of Antifungal Resistance
Expert Panel Review of Skin and Hair Dermatophytoses in an Era of Antifungal Resistance
Dermatophytoses are fungal infections of the skin, hair, and nails that affect approximately 25% of the global population....
Early and Sustained Improvements in Symptoms and Quality of Life with Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: 52-Week Results from Two Phase III Randomized Clinical Trials (Measure Up 1 and Measure Up 2)
Early and Sustained Improvements in Symptoms and Quality of Life with Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: 52-Week Results from Two Phase III Randomized Clinical Trials (Measure Up 1 and Measure Up 2)
Atopic dermatitis is a chronic inflammatory disease characterized by increased itch, skin pain, poor sleep quality, and ot...
Secondary Bacterial Infections in Patients with Atopic Dermatitis or Other Common Dermatoses
Secondary Bacterial Infections in Patients with Atopic Dermatitis or Other Common Dermatoses
Secondary bacterial infections of common dermatoses such as atopic dermatitis, ectoparasitosis, and varicella zoster virus...
Ultrasound Surveillance in Melanoma Management: Bridging Diagnostic Promise with Real-World Adherence: A Systematic Review and Meta-Analysis
Ultrasound Surveillance in Melanoma Management: Bridging Diagnostic Promise with Real-World Adherence: A Systematic Review and Meta-Analysis
Ultrasound surveillance has become the new standard of care in stage III melanoma after the 2017 Multicenter Selective Lym...
Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates
Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates
Merkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine differentiation. Its carcinogenesis is b...
Treat-to-Target in Atopic Dermatitis
Treat-to-Target in Atopic Dermatitis
Atopic dermatitis is one of the most common inflammatory skin diseases among children and adults. Over the last 5 years, t...
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