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A lanthanide–carbon triple bond stabilized within a fullerene cage
A lanthanide–carbon triple bond stabilized within a fullerene cage
Metal–ligand multiple bonds are ubiquitous in coordination and organometallic chemistry. In contrast, lanthanideR...
Reversible formation and control of linear conjugation in polymers
Reversible formation and control of linear conjugation in polymers
The emergence of organic semiconductors has laid the foundation for the field of plastic electronics. Controlling π-c...
Accessing sulfonamides via formal SO2 insertion into C–N bonds
Accessing sulfonamides via formal SO2 insertion into C–N bonds
Functional group interconversions are particularly sought after by medicinal chemists as a means to enable both lead optim...
New-to-nature biocompatible chemistry for plastic waste upcycling
New-to-nature biocompatible chemistry for plastic waste upcycling
Synthetic and biological chemistry are traditionally seen as separate fields. Now, a biocompatible chemical reaction enabl...
Biosynthesis of an elusive sulfur-containing functional group
Biosynthesis of an elusive sulfur-containing functional group
Chemists first synthesized acylsulfenic acids in the 1990s, but natural products containing this labile moiety have so far...
Adaptive dynamic kinetic resolution enables alteration of chiral induction with ring sizes
Adaptive dynamic kinetic resolution enables alteration of chiral induction with ring sizes
Dynamic kinetic resolution (DKR) is an efficient chiral induction strategy that transforms both enantiomers of the substra...
A biocompatible Lossen rearrangement in Escherichia coli
A biocompatible Lossen rearrangement in Escherichia coli
Nature has evolved an exquisite yet limited set of chemical reactions that underpin the function of all living organisms. ...
Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis
Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis
Polyunsaturated fatty acids (PUFAs) represent a fundamental and essential class of lipids that exhibit versatile biofuncti...
Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking
Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking
Resolving protein–protein interactions (PPIs) inside biomolecular condensates is crucial for elucidating their funct...
Molecular-scale dissipative chemistry drives the formation of nanoscale assemblies and their macroscale transport
Molecular-scale dissipative chemistry drives the formation of nanoscale assemblies and their macroscale transport
Fuelled chemical systems have considerable functional potential that remains largely unexplored. Here we report an approac...
Pore configuration control in hybrid azolate ultra-microporous frameworks for sieving propylene from propane
Pore configuration control in hybrid azolate ultra-microporous frameworks for sieving propylene from propane
Developing porous adsorbents for the complete sieving of propylene/propane mixtures represents an alternative method to en...
Catalysis-enabled amine sorting
Catalysis-enabled amine sorting
Multicomponent couplings offer powerful approaches for rapidly increasing molecular complexity, but typically require func...
Dynamic amine sorting enables multiselective construction of unsymmetrical chiral diamines
Dynamic amine sorting enables multiselective construction of unsymmetrical chiral diamines
Precisely differentiating chemicals featuring minor discrepancies is the prerequisite for achieving high selectivities in ...
Isolation and characterization of a triplet nitrene
Isolation and characterization of a triplet nitrene
Nitrene radical compounds are short-lived intermediates in a variety of nitrogen-involved transformations. They feature ei...
Cyclic amine ring expansion
Cyclic amine ring expansion
Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with th...
Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion
Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion
Saturated N-heterocycles are ubiquitous structures among natural products and biologically active compounds. Therefore, th...
Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon
Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon
The relationship between the shape of a molecule and its chemical reactivity is a central tenet in chemistry. However, the...
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms
Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of protein stability and cell sig...
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
While natural terpenoid cyclases generate complex terpenoid structures via cationic mechanisms, alternative radical cycliz...
A template for artificial life
A template for artificial life
Selection rules play an important role in Darwinian evolution. Now, it has been shown that selective templation enables th...
Phosphorus-mediated hydrogenation catalysis
Phosphorus-mediated hydrogenation catalysis
Hydrogenation catalysis is commonly associated with (noble) transition metals that undergo oxidative addition of H2 and su...
Light strikes gold to purify water
Light strikes gold to purify water
Hydroxyl radicals (·OH) are important reactive oxygen species in environmental chemistry. The most efficient way to g...
Copper catalysed asymmetric amination
Copper catalysed asymmetric amination
Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are chal...
Blocking and rescuing tryptophan interactions
Blocking and rescuing tryptophan interactions
Expansion of the genetic code can enable precise manipulation of proteins through selective functionalization of specific ...
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging
In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000–1,700 nm) and extended SWIR (ESWIR, 1,700&...
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water
Hydrogen evolution is an important fuel-generating reaction that has been subject to mechanistic debate about the roles of...
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine undergoes a range of acylations, i...
Lifting iron higher and higher
Lifting iron higher and higher
Biological and synthetic catalysts often utilize iron in high oxidation states (+IV and greater) to perform challenging mo...
Bridging the information gap in organic chemical reactions
Bridging the information gap in organic chemical reactions
The varying quality of scientific reports is a well-recognized problem and often results from a lack of standardization an...
Expanding the molecular language of protein liquid–liquid phase separation
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation has important implications for anal...
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