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Prevalence and Predictors of Response to Antifibrotics in Long-Term Survivors with Idiopathic Pulmonary Fibrosis
Prevalence and Predictors of Response to Antifibrotics in Long-Term Survivors with Idiopathic Pulmonary Fibrosis
The natural history of IPF remains unpredictable despite antifibrotic treatment. In addition, some patients discontinue tr...
Differences in Blood Eosinophil Level During Stable Disease and During Exacerbation of COPD and Exacerbation Risks
Differences in Blood Eosinophil Level During Stable Disease and During Exacerbation of COPD and Exacerbation Risks
Although blood eosinophil count (BEC) has been extensively studied as a biomarker in chronic obstructive pulmonary disease...
Toll-Like Receptor 4 and 8 are Overexpressed in Lung Biopsies of Human Non-small Cell Lung Carcinoma
Toll-Like Receptor 4 and 8 are Overexpressed in Lung Biopsies of Human Non-small Cell Lung Carcinoma
Lung cancer is the leading cause of cancer death worldwide which includes two main types of carcinoma distinguished in non...
FLRT3 Overexpression Attenuates Ischemia–Reperfusion Induced Vascular Hyperpermeability and Lung Injury Through RND3
FLRT3 Overexpression Attenuates Ischemia–Reperfusion Induced Vascular Hyperpermeability and Lung Injury Through RND3
Pulmonary ischemia/reperfusion injury (IRI) causes endothelial barrier dysfunction and increased vascular permeability. Fi...
Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry
Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry
We used data from the IPF-PRO Registry of patients with idiopathic pulmonary fibrosis (IPF) to identify characteristics th...
Supratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study
Supratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study
In severe asthma, intensive (“supratherapeutic”) doses of inhaled corticosteroids (ICS) are often used. The pr...
SIRT2 Regulates Apoptosis Signaling in Hyperoxic Acute Lung Injury
SIRT2 Regulates Apoptosis Signaling in Hyperoxic Acute Lung Injury
Oxygen therapy is helpful for patients with breathing difficulties; however, sustained supplementation with high-concentra...
Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study
Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study
Toll-like receptor 4 (TLR4) is a transmembrane receptor promoting pro-inflammatory signalling, that is associated with the...
MIP-3-Alpha and MIP-3-Beta as Early Predictors of Pneumonia in Polytraumatized Patients
MIP-3-Alpha and MIP-3-Beta as Early Predictors of Pneumonia in Polytraumatized Patients
Pneumonia is one of the most common complications in patients suffering multiple traumas and is associated with an excepti...
Factors Influencing the Efficacy and Safety of Monoclonal Antibody Biologics in Chronic Obstructive Pulmonary Disease: A Meta-analysis of Randomized Controlled Trials
Factors Influencing the Efficacy and Safety of Monoclonal Antibody Biologics in Chronic Obstructive Pulmonary Disease: A Meta-analysis of Randomized Controlled Trials
Monoclonal antibody therapies targeting specific inflammatory pathways have shown potential in treating chronic obstructiv...
The Role of HDAC3 in Pulmonary Diseases
The Role of HDAC3 in Pulmonary Diseases
Histone deacetylases (HDACs), a class of enzymes involved in epigenetic modifications, play a pivotal role in modulating c...
Effect of Electronic Cigarette Vapour Exposure on Ca- and cAMP-Dependent Ion Transport in Human Airway Epithelial Cells
Effect of Electronic Cigarette Vapour Exposure on Ca- and cAMP-Dependent Ion Transport in Human Airway Epithelial Cells
The popularity of electronic cigarettes (e-cigarettes) has grown exponentially over the past few years, and teenagers now ...
Comparative Efficacy of CFTR Modulators: A Network Meta-analysis
Comparative Efficacy of CFTR Modulators: A Network Meta-analysis
The objective was to study comparative efficacies of cystic fibrosis transmembrane conductance regulator (CFTR) modulators...
Plasma Reticulocalbin 3 (RCN3) is a Novel Biomarker for the Early Diagnosis of Hepatopulmonary Syndrome in Cirrhotic Patients
Plasma Reticulocalbin 3 (RCN3) is a Novel Biomarker for the Early Diagnosis of Hepatopulmonary Syndrome in Cirrhotic Patients
Hepatopulmonary syndrome (HPS) is a severe complication in cirrhotic patients and characterized by abnormal intrapulmonary...
Relationship of Lung Function and the Preserved Ratio Impaired Spirometry Pattern with Aortic and Left Ventricular Structure and Function on Magnetic Resonance Imaging: The Jackson Heart Study
Relationship of Lung Function and the Preserved Ratio Impaired Spirometry Pattern with Aortic and Left Ventricular Structure and Function on Magnetic Resonance Imaging: The Jackson Heart Study
Low lung function and Preserved Ratio Impaired Spirometry (PRISm) have been associated with increased co-morbid cardiovasc...
Update 2025: Management of Non‑Small-Cell Lung Cancer
Update 2025: Management of Non‑Small-Cell Lung Cancer
Lung cancer remains the leading cause of cancer-related mortality worldwide. Since 2024, the non–small-cell...
High-Density Lipoprotein Cholesterol Trajectories and Lung Function Decline: A Prospective Cohort Study
High-Density Lipoprotein Cholesterol Trajectories and Lung Function Decline: A Prospective Cohort Study
Cholesterol regulation is essential to maintain pulmonary homeostasis. Studies suggest that increased high-density lipopro...
The Role of Triple CFTR Modulator Therapy in Reducing Systemic Inflammation in Cystic Fibrosis
The Role of Triple CFTR Modulator Therapy in Reducing Systemic Inflammation in Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disease caused by mutations in the CFTR gene, leading to multisystemic complications, pa...
Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors
Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors
ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body...
Longitudinal Cough Frequency Monitoring in Persistent Coughers: Daily Variability and Predictability
Longitudinal Cough Frequency Monitoring in Persistent Coughers: Daily Variability and Predictability
We determined the cough counts and their variability in subjects with persistent cough for 30 days. The Hyfe coug...
Deep Learning Models for Predicting Malignancy Risk in CT-Detected Pulmonary Nodules: A Systematic Review and Meta-analysis
Deep Learning Models for Predicting Malignancy Risk in CT-Detected Pulmonary Nodules: A Systematic Review and Meta-analysis
There has been growing interest in using artificial intelligence/deep learning (DL) to help diagnose prevalent diseases ea...
Correction to: Lung Transplantation in the United States for COVID-19 Related Lung Disease During the Pandemic
Correction to: Lung Transplantation in the United States for COVID-19 Related Lung Disease During the Pandemic
In this article, the author noticed that the Title and some values in the Results section, Figures 1, 2, 4 caption and Fig...
ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension
ECMO Bridge to Lung Transplant in Children with Idiopathic Pulmonary Arterial Hypertension
Idiopathic pulmonary arterial hypertension (IPAH) represents an important clinical indication for lung transplant (LTx) in...
Utility of the 52-Gene Risk Score to Identify Patients with Idiopathic Pulmonary Fibrosis at Greater Risk of Mortality in the Era of Antifibrotic Therapy
Utility of the 52-Gene Risk Score to Identify Patients with Idiopathic Pulmonary Fibrosis at Greater Risk of Mortality in the Era of Antifibrotic Therapy
We investigated whether a 52-gene signature was associated with transplant-free survival and other clinically meaningful o...
Pseudomonas aeruginosa Infection and Inflammation in Cystic Fibrosis: A Pilot Study With Lung Explants and a Novel Histopathology Scoring System
Pseudomonas aeruginosa is the predominant bacterial pathogen colonizing the cystic fibrosis (CF) lung. Mixed populations o...
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model
Over 550 loci have been associated with human pulmonary function in genome-wide association studies (GWAS); however, the c...
The Lymphatic Highway: How Lymphatics Drive Lung Health and Disease
The Lymphatic Highway: How Lymphatics Drive Lung Health and Disease
The pulmonary lymphatic system has emerged as a critical regulator of lung homeostasis and a key contributor to the pathog...
Lung Transplantation in the United States for COVID-19 Related Lung Disease During the Pandemic
Lung Transplantation in the United States for COVID-19 Related Lung Disease During the Pandemic
Lung transplantation (LTx) is a potential intervention for end-stage COVID-19 lung disease. Current literature is sparse r...
Effects of Azithromycin on Blood Inflammatory Gene Expression and Cytokine Production in Sarcoidosis
Effects of Azithromycin on Blood Inflammatory Gene Expression and Cytokine Production in Sarcoidosis
In sarcoidosis granulomas, monocyte-derived macrophages are activated by pro-inflammatory cytokines including TNF and IL-6...
The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies
The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies
Azithromycin is an effective treatment for various respiratory conditions but its effect on cough is poorly understood. We...
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