Supratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study

Côté A, Godbout K, Boulet LP (2020) The management of severe asthma in 2020. Biochem Pharmacol 1(179):114112

Article  Google Scholar 

Busse WW, Kraft M (2022) Current unmet needs and potential solutions to uncontrolled asthma. Eur Respir Rev 31(163):210176

Article  PubMed  PubMed Central  Google Scholar 

Wang E, Wechsler ME, Tran TN, Heaney LG, Jones RC, Menzies-Gow AN et al (2020) Characterization of severe asthma worldwide: data from the international severe asthma registry. Chest 157(4):790–804

Article  CAS  PubMed  Google Scholar 

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ et al (2014) International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 43(2):343–373

Article  CAS  PubMed  Google Scholar 

Global Initiative For Asthma (2023) Global strategy for astma management and prevention. www.ginasthma.org. Accessed 24 May 2024

Shah PA, Brightling C (2023) Biologics for severe asthma—which, when and why? Respirology 28(8):709–721

Article  PubMed  Google Scholar 

Masoli M, Holt S, Weatherall M, Beasley R (2004) Dose-response relationship of inhaled budesonide in adult asthma: a meta-analysis. Eur Respir J 23(4):552–558

Article  CAS  PubMed  Google Scholar 

Holt S, Suder A, Weatherall M, Cheng S, Shirtcliffe P, Beasley R (2001) Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis. BMJ 323(7307):253–256

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye Q, He XO, D’Urzo A (2017) A review on the safety and efficacy of inhaled corticosteroids in the management of asthma. Pulm Ther 3(1):1–18

Article  Google Scholar 

Dahl R (2006) Systemic side effects of inhaled corticosteroids in patients with asthma. Respir Med 100(8):1307–1317

Article  PubMed  Google Scholar 

Kelly HW, Nelson HS (2003) Potential adverse effects of the inhaled corticosteroids. J Allergy Clin Immunol 112(3):469–478

Article  CAS  PubMed  Google Scholar 

Buhl R (2006) Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Allergy 61(5):518–526

Article  CAS  PubMed  Google Scholar 

Kankaanranta H, Viinanen A, Ilmarinen P, Hisinger-Mölkänen H, Mehtälä J, Ylisaukko-oja T et al (2024) Comorbidity burden in severe and nonsevere asthma: a nationwide observational study (FINASTHMA). J Allergy Clin Immunol: In Practice. 12(1):135-145.e9

Google Scholar 

von Bülow A, Hansen S, Sandin P, Ernstsson O, Janson C, Lehtimäki L et al (2023) Severe asthma trajectories in adults: findings from the NORDSTAR cohort. Eur Respir J 62(3):2202474

Article  Google Scholar 

Håkansson KEJ, Backer V, Ulrik CS (2021) Socioeconomic biases in asthma control and specialist referral of possible severe asthma. Eur Respir J 58(6):2100741

Article  PubMed  Google Scholar 

Håkansson KEJ, Guerrero SC, Backer V, Ulrik CS, Rastogi D (2023) Burden and unmet need for specialist care in poorly controlled and severe childhood asthma in a Danish nationwide cohort. Respir Res 24(1):173

Article  PubMed  PubMed Central  Google Scholar 

Maijers I, Kearns N, Harper J, Weatherall M, Beasley R (2020) Oral steroid-sparing effect of high-dose inhaled corticosteroids in asthma. Eur Respir J 55(1):1901147

Article  CAS  PubMed  Google Scholar 

Dalal AA, Duh MS, Gozalo L, Robitaille MN, Albers F, Yancey S et al (2016) Dose-response relationship between long-term systemic corticosteroid use and related complications in patients with severe asthma. J Manag Care Spec Pharm 22(7):833–847

PubMed  Google Scholar 

Volmer T, Effenberger T, Trautner C, Buhl R (2018) Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J 52(4):1800703

Article  PubMed  Google Scholar 

Bloechliger M, Reinau D, Spoendlin J, Chang SC, Kuhlbusch K, Heaney LG et al (2018) Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis. Respir Res 19(1):75

Article  PubMed  PubMed Central  Google Scholar 

Hansen S, Hilberg O, Ulrik CS, Bodtger U, Rasmussen LM, Assing KD et al (2020) The Danish severe asthma register: an electronic platform for severe asthma management and research. Eur Clin Respir J. 8(1):1842117

Article  PubMed  PubMed Central  Google Scholar 

Skov IR, Madsen H, Henriksen DP, Andersen JH, Pottegård A, Davidsen JR (2022) Low-dose oral corticosteroids in asthma associates with increased morbidity and mortality. Eur Respir J 60(3):2103054

Article  PubMed  Google Scholar 

Soendergaard MB, Hjortdahl F, Hansen S, Bjerrum AS, von Bülow A, Hilberg O et al (2025) Pre-biologic disease trajectories are associated with morbidity burden and biologic treatment response in severe asthma. Eur Respir J:2401497. http://publications.ersnet.org/lookup/doi/https://doi.org/10.1183/13993003.01497-2024

Hansen S, Baastrup Søndergaard M, von Bülow A, Bjerrum AS, Schmid J, Rasmussen LM et al (2024) Clinical response and remission in patients with severe asthma treated with biologic therapies. Chest 165(2):253–266

Article  CAS  PubMed  Google Scholar 

Pavord ID, Tran TN, Jones RC, Nuevo J, van den Berge M, Brusselle GG et al (2023) Effect of stepping up to high-dose inhaled corticosteroids in patients with asthma: UK database study. J Allergy Clin Immunol Pract 11(2):532–543

Article  CAS  PubMed  Google Scholar 

Beasley R, Harper J, Bird G, Maijers I, Weatherall M, Pavord ID (2019) Inhaled corticosteroid therapy in adult asthma: time for a new therapeutic dose terminology. Am J Respir Crit Care Med 199(12):1471–1477

Article  CAS  PubMed  Google Scholar 

Cazzola M, Rogliani P, Calzetta L, Matera MG (2020) Pharmacogenomic Response of Inhaled Corticosteroids for the Treatment of Asthma: Considerations for Therapy. Pharmgenomics Pers Med 13:261–271

CAS  PubMed  PubMed Central  Google Scholar 

Milara J, Morell A, Roger I, Montero P, Cortijo J (2023) Mechanisms underlying corticosteroid resistance in patients with asthma: a review of current knowledge. Expert Rev Respir Med 17(8):701–715

Article  CAS  PubMed  Google Scholar 

Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM et al (2002) Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 109(3):410–418

Article  CAS  PubMed  Google Scholar 

Masayuki H, Koichiro K (2004) Dose–response relationship for inhaled corticosteroids and the add-on effect of long-acting β2-adrenergic receptor agonists in adult chronic asthmatics. Allergol Int 53(4):291–299

Article  Google Scholar 

Pauwels RA, Löfdahl CG, Postma DS, Tattersfield AE, O’Byrne P, Barnes PJ et al (1997) Effect of inhaled formoterol and budesonide on exacerbations of asthma: Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 337(20):1405–1411

Article  CAS  PubMed  Google Scholar 

Broersen LHA, Pereira AM, Jørgensen JOL, Dekkers OM (2015) Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab 100(6):2171–2180

Article  CAS  PubMed  Google Scholar 

Brennan V, Martin-Grace J, Greene G, Heverin K, Mulvey C, McCartan T et al (2022) The contribution of oral and inhaled glucocorticoids to adrenal insufficiency in asthma. J Allergy Clin Immunol Pract 10(10):2614–2623

Article  CAS  PubMed  Google Scholar 

von Bülow A, Hansen S, Sandin P, Cooper A, Ernstsson O, Geale K et al (2025) Use of high-dose inhaled corticosteroids and risk of corticosteroid related adverse events in asthma -findings from the NORDSTAR cohort. J Allergy Clin Immunol Pract. https://doi.org/10.1016/j.jaip.2025.01.023

Article  Google Scholar 

Bloom CI, Yang F, Hubbard R, Majeed A, Wedzicha JA (2024) Association of dose of inhaled corticosteroids and frequency of adverse events. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.202402-0368OC

Comments (0)

No login
gif