SCI Abstract

search
+
Boosting effect of high-dose influenza vaccination on innate immunity among elderly
Clinical Research and Public HealthImmunologyVaccines Open Access | 10.1172/jci.insight.184128 ...
A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles
MT-JIP3 induces JNK signaling–dependent apoptosis in HeLa cells, reducing cell growth, and JIP4 interacts with JIP3. Sinc...
Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2
Research ArticleGeneticsNeuroscience Open Access | 10.1172/jci.insight.185159 Pierre-Yves Bar...
Tape strip expression profiling of juvenile dermatomyositis skin reveals mitochondrial dysfunction contributing to disease endotype
JDM cohort clinical characteristics at enrollment visit. There were 28 JDM and 20 healthy control (CTL) patients in this ...
Development and characterization of an Sf-1-Flp mouse model
Research ArticleMetabolismNeuroscience Open Access | 10.1172/jci.insight.190105 Marco Galvan,...
Testosterone affects female CD4+ T cells in healthy individuals and autoimmune liver diseases
Research ArticleHepatologyImmunology Open Access | 10.1172/jci.insight.184544 Lara Henze,1 ...
In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects
Effects of IVF on testis weight and histology. To ascertain whether IVF could influence male reproductive function, we fi...
Apremilast reduces co-occurring alcohol drinking and mechanical allodynia and regulates central amygdala GABAergic transmission
Research ArticleNeurosciencePublic Health Open Access | 10.1172/jci.insight.189732 Valentina ...
Anoctamin-5 deficiency enhances ATG9A-dependent autophagy, inducing osteogenesis and gnathodiaphyseal dysplasia–like bone formation
Autophagic flux is promoted by the absence of Ano5 in mCOBs. To investigate whether autophagic activity is implicated in ...
MSC transplantation ameliorates depression in lupus by suppressing Th1 cell–shaped synaptic stripping
Research ArticleInflammationNeuroscience Open Access | 10.1172/jci.insight.181885 Xiaojuan Ha...
Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk
Research ArticleMetabolismOncology Open Access | 10.1172/jci.insight.182694 Erin D. Giles,1,2...
Rapamycin immunomodulation utilizes time-dependent alterations of lymph node architecture, leukocyte trafficking, and gut microbiome
Rapamycin reduces lymphocytes in LNs and spleen. To investigate the immunological effects of rapamycin within secondary l...
Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns
Research ArticleAngiogenesisCardiology Open Access | 10.1172/jci.insight.186812 Lingling Yan,...
Chronic pancreatitis in T7C140S mice with misfolding cationic trypsinogen mutant
Hereditary chronic pancreatitis (CP) is caused by risk alleles that increase the intrapancreatic activation of the digest...
Glycine receptor activation promotes pancreatic islet cell proliferation via the PI3K/mTORC1/p70S6K pathway
Research ArticleEndocrinology Open Access | 10.1172/jci.insight.178754 Ziyi Zhang,1,2 Wen...
A small molecule PKCε inhibitor reduces hyperalgesia induced by paclitaxel or opioid withdrawal
Characterization of the PKCε inhibitor CP612. We developed an efficient enantioselective synthesis and carried out struct...
The ACTH test fails to diagnose adrenal insufficiency and augments cytokine production in sepsis
The ACTH test fails to correctly identify adrenal insufficiency in early/acute and middle/subacute stages of sepsis. Firs...
CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest
Research ArticleImmunologyPulmonology Open Access | 10.1172/jci.insight.185061 Richard P. Ram...
Vitamin A treatment restores vision failures arising from Leber’s hereditary optic neuropathy–linked mtDNA mutation
scRNA-Seq reveals changes in retinal composition and transcriptional profiles. To investigate the impact of the ND6 mutat...
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation
Research ArticleAgingImmunology Open Access | 10.1172/jci.insight.187271 Cody S. Nelson,1,2 ...
The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.181309 Arne Echterhof,1,...
The STAT3/SETDB2 axis dictates NF-κB–mediated inflammation in macrophages during wound repair
Research ArticleInflammation Open Access | 10.1172/jci.insight.179017 Kevin D. Mangum,1,2 ...
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
IACS-70654 inhibited the growth of neutrophil-enriched syngeneic mammary tumor models. To examine the effects of CBP/P300...
Epstein-Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues
Sex as a biological variable. For all experiments, animals (described below) were distributed into different experimental...
Development of a humanized mouse model with functional human materno-fetal interface immunity
Establishment of a pregnant HIS mouse model. We first examined whether Thy/HSC HIS mice generated using the conventional ...
Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.179525 Ruth D. Azaria,1 Ad...
CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus
Immune cell landscape in LP skin consists predominantly of CD8+ T cells. We collected 4-millimeter skin biopsies from les...
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
Research ArticleCardiologyMetabolism Open Access | 10.1172/jci.insight.184940 Le Phuong Nguye...
Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation
General composition of the breastmilk T cell compartment throughout lactation. Live T cells were present in human breastm...
Targeted long-read sequencing enriches disease-relevant genomic regions of interest to provide complete Mendelian disease diagnostics
Research ArticleGeneticsOphthalmology Open Access | 10.1172/jci.insight.183902 Kenji Nakamich...
Load More
format_indent_increase