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The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.181309 Arne Echterhof,1,...
The STAT3/SETDB2 axis dictates NF-κB–mediated inflammation in macrophages during wound repair
Research ArticleInflammation Open Access | 10.1172/jci.insight.179017 Kevin D. Mangum,1,2 ...
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
IACS-70654 inhibited the growth of neutrophil-enriched syngeneic mammary tumor models. To examine the effects of CBP/P300...
Epstein-Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues
Sex as a biological variable. For all experiments, animals (described below) were distributed into different experimental...
Development of a humanized mouse model with functional human materno-fetal interface immunity
Establishment of a pregnant HIS mouse model. We first examined whether Thy/HSC HIS mice generated using the conventional ...
Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.179525 Ruth D. Azaria,1 Ad...
CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus
Immune cell landscape in LP skin consists predominantly of CD8+ T cells. We collected 4-millimeter skin biopsies from les...
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
Research ArticleCardiologyMetabolism Open Access | 10.1172/jci.insight.184940 Le Phuong Nguye...
Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation
General composition of the breastmilk T cell compartment throughout lactation. Live T cells were present in human breastm...
Targeted long-read sequencing enriches disease-relevant genomic regions of interest to provide complete Mendelian disease diagnostics
Research ArticleGeneticsOphthalmology Open Access | 10.1172/jci.insight.183902 Kenji Nakamich...
Quantitative proteomics of patient fibroblasts reveal biomarkers and diagnostic signatures of mitochondrial disease
Clinical MedicineMetabolism Open Access | 10.1172/jci.insight.178645 Sandrina P. Correia,1,2 ...
Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy
Spontaneous seizures and seizure-induced death in mice with selective expression of mutant Nav1.6 in PV interneurons. We ...
Characterization of SMA type II skeletal muscle from treated patients shows OXPHOS deficiency and denervation
Type II SMA muscle has similar levels of SMN RNA and protein to those of scoliotic controls. To characterize the muscle o...
Antibody levels versus vaccination status in the outcome of older adults with COVID-19
Participants. During the period spanning from August 1, 2021, and April 10, 2022, a total of 1,254 hospitalized patients ...
GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension
Sex as a biological variable. Our study examined male and female animals, as well as lung tissue samples from both male a...
A positive cytokine/chemokine feedback loop establishes plasmacytoid DC–driven autoimmune pancreatitis in IgG4-related disease
The uninflamed pancreas harbors cDCs that express high levels of TLR3. As alluded to in the Introduction, the model of AI...
Androgen production, uptake, and conversion (APUC) genes define prostate cancer patients with distinct clinical outcomes
Clinical MedicineOncology Open Access | 10.1172/jci.insight.183158 Hannah E. Bergom,1,2 E...
Glymphatic influx and clearance are perturbed in Huntington’s disease
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.172286 Hongshuai Liu,1 Lin...
Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis
Neuronal Slc39a8 deletion leads to reduced Mn levels in the brain. To identify the role of SLC39A8 in neurons, we generat...
Immune exhaustion in ME/CFS and long COVID
Participants. This current study included n = 18 healthy controls (HC), n = 14 participants with ME/CFS, and n = 15 parti...
Joint-specific rheumatoid arthritis fibroblast-like synoviocyte regulation identified by integration of chromatin access and transcriptional activity
Computational and experimental overview To test the hypothesis that FLS have distinct joint-specific phenotypes and behav...
Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors
Research ArticleInflammationOncology Open Access | 10.1172/jci.insight.165356 Lisa A. Ridnour,1...
Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury
Genetic deficiency of the miR-15a/16-1 cluster promotes long-term recovery of sensorimotor and cognitive functions in mic...
Spatial analysis of recurrent glioblastoma reveals perivascular niche organization
Multiplexed imaging uncovers correlations between genotype and TME. In our previous study, we showed that the single-cell...
Coordinated immune dysregulation in juvenile dermatomyositis revealed by single-cell genomics
Research Article Open Access | 10.1172/jci.insight.176963 Gabrielle Rabadam,1,2 Camilla Wib...
N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance
Mgat5 loss sensitizes cancer cells to immune clearance. Analysis of The Cancer Genome Atlas Program (TCGA) and Genotype-T...
Reduced decay-accelerating factor expression promotes complement-mediated cystogenesis in murine ADPKD
Research ArticleNephrology Open Access | 10.1172/jci.insight.175220 Sofia Bin,1,2,3 Miran Y...
Endothelial to mesenchymal Notch signaling regulates skeletal repair
Transcriptome analysis of early fracture healing. Bones heal well in healthy individuals, but aging and confounding disea...
BTK inhibitor–induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α
Research ArticleImmunologyInfectious disease Open Access | 10.1172/jci.insight.176162 Diego A. ...
Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE
Research ArticleImmunology Open Access | 10.1172/jci.insight.179433 Artur Wilhelm,1,2 David...
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