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A multi-omics study reveals molecular characteristics and therapeutic targets of salidroside in reducing TGF-β2-induced ECM expression

Glaucoma is a leading cause of irreversible blindness worldwide, with primary open-angle glaucoma (POAG) being the most co...

Experimental Eye Research

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Fluorometholone inhibits corneal epithelial proliferation, migration via targeting Rho GTPases: RhoA, Rac1, and Cdc42

Refractive error stands as a primary cause of reversible visual impairment. In recent decades, myopia has emerged as a glo...

Experimental Eye Research

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Vitreous proteomic insights into the pathogenesis of nonarteritic anterior ischemic optic neuropathy

Non-arteritic anterior ischemic optic neuropathy (NAION) is the most prevalent non-glaucomatous optic nerve disorder in pa...

Experimental Eye Research

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Investigating shared diagnostic genes and mechanisms between metabolic syndrome and dry eye disease via integrated bioinformatics analysis and in vivo validation

The Tear Film and Ocular Surface Dry Eye Workshop (TFOS DEWS) II defines DED as a multifactorial disease of the ocular sur...

Experimental Eye Research

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Optimizing intracameral injection for targeted gene therapy and glaucoma model development

The unique anatomy and physiology of the eye pose significant challenges for drug delivery. Both static barriers such as t...

Experimental Eye Research

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The association of trimethylamine N-oxide with diabetic retinopathy Pathology: Insights from network toxicology and molecular docking analysis

Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus, representing a significant cause of ...

Experimental Eye Research

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Oleic acid association with primary angle-closure glaucoma: A finding using metabolomics

Glaucoma is a leading cause of blindness worldwide, which affected approximately 95 million people in 2022. This number is...

Experimental Eye Research

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Silencing METTL3 and YTHDF2 increases HSP70 expression and promotes corneal epithelial healing

The corneal epithelium is the barrier that protects the inner corneal tissue from harmful factors. Delayed healing of the ...

Experimental Eye Research

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Comment on “Involvement of TGF-β signaling pathway-associated genes in the corneal endothelium of patients with Fuchs endothelial corneal dystrophy” by Nakagawa et al.

Experimental Eye Research

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Quantitative comparison of inner and outer retinal intraretinal hyperreflective foci in age-related macular degeneration

To quantitatively compare the spectral-domain optical coherence tomography (SD-OCT) characteristics of inner and outer int...

Experimental Eye Research

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Depletion of Polypyrimidine tract binding protein 1 (ptbp1) activates Müller glia-derived proliferation during zebrafish retina regeneration via modulation of the senescence secretome

Polypyrimidine Tract Binding protein 1 (PTB) is an alternative splicing factor linked to neuronal induction and maturation...

Experimental Eye Research

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A multiomic study of retinal tissues in mice with direct ocular exposure to vesicants

This study employed a multiomic approach to investigate retinal tissue damage following direct ocular exposure (DOE) to ve...

Experimental Eye Research

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Grx2 maintains GSH/GSSG homeostasis to enhance GPX4-mediated ferroptosis defense in UVB irradiation induced cataract

Millions worldwide are afflicted by cataract (Khairallah et al., 2015; Lee and Afshari, 2017). The etiology of cataracts i...

Experimental Eye Research

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Exploring the link between Co-stimulatory gene polymorphisms and clinical manifestations in Graves' ophthalmopathy

Graves' ophthalmopathy (GO) is a debilitating autoimmune disorder that affects the orbital and periorbital tissues. It occ...

Experimental Eye Research

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Functional characterization of CatTohm, a mouse AQP0 mutation that causes oxidative stress, cytotoxicity, dominant congenital lens cataract and microphthalmia

Congenital lens cataracts, the most common form of blindness in children worldwide (Evans et al., 1996; Lambert, 1994) app...

Experimental Eye Research

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The effects of pigment epithelium-derived factor and associated peptides on the differentiation of retinal ganglion cells from human-induced pluripotent stem cells

Optic nerve damage leads to degeneration and atrophy of retinal ganglion cells (RGCs), including various types such as gla...

Experimental Eye Research

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A standardized in vivo protocol for ocular biodistribution of gold nanoparticles

New nanoparticle-based delivery systems are being developed to prolong drug retention time, improve drug penetration acros...

Experimental Eye Research

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Enabling visualization of GFAP-positive retinal glial cells, neurons and microvasculature in three-dimensions

We recently established a new technique to study the three-dimensional relationship between retinal glial cells, neurons, ...

Experimental Eye Research

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Identifying a role for oxytosis/ferroptosis in Pde6b-associated retinitis pigmentosa

Madison E. Weiss: Writing – review & editing, Validation, Methodology, Investigation, Data curation. Paola E. Parrales...

Experimental Eye Research

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Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging

The retina is a highly metabolically active tissue, requiring adequate availability of oxygen and other metabolites to gen...

Experimental Eye Research

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Long-term persistent exposure to cigarette smoke induces AhR driven corneal endothelial dysfunction in mice