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Epigenetic Modifications in Vitiligo
Epigenetic Modifications in Vitiligo
Vitiligo is an autoimmune depigmenting skin disorder and can affect the mental health of the patients. Current research su...
Effectiveness and Safety of Nemolizumab in Patients with Prurigo Nodularis: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effectiveness and Safety of Nemolizumab in Patients with Prurigo Nodularis: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Prurigo nodularis (PN) is a chronic, severely pruritic condition that markedly impairs quality of life. Existing treatment...
Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential
Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by chronic inflammation and multi-organ d...
Inhalant Mediated Allergy: Immunobiology, Clinical Manifestations and Diagnosis
Inhalant Mediated Allergy: Immunobiology, Clinical Manifestations and Diagnosis
Inhalant allergen–mediated respiratory diseases, including asthma and allergic rhinitis, have become increasing glob...
Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma
Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma
Asthma is a chronic respiratory disorder affecting individuals across all age groups. It is characterized by airway inflam...
Questionnaire for Clinical Diagnosis of House Dust Mite’s Allergy Approved by Delphi Consensus
Questionnaire for Clinical Diagnosis of House Dust Mite’s Allergy Approved by Delphi Consensus
Despite house dust mite (HDM)-allergy is the most frequent in the world, no standard questionnaire exists to help physicia...
Molecular Diagnosis to IgE-mediated Wheat Allergy and Wheat-Dependent Exercise-Induced Anaphylaxis
Molecular Diagnosis to IgE-mediated Wheat Allergy and Wheat-Dependent Exercise-Induced Anaphylaxis
IgE-mediated wheat allergy is an emerging problem worldwide, particularly prevalent in Northern Europe and parts of Asia. ...
Mechanisms and Therapeutic Implications of EZH2 in Nasal Diseases
Mechanisms and Therapeutic Implications of EZH2 in Nasal Diseases
Enhancer of zeste homolog 2 (EZH2), a protein encoded by the EZH2 gene, is a crucial subunit in polycomb repressive comple...
Neutrophilic Urticarial Dermatosis: A Window into Systemic Inflammation and Autoimmune Disorders
Neutrophilic Urticarial Dermatosis: A Window into Systemic Inflammation and Autoimmune Disorders
Neutrophilic urticarial dermatosis (NUD) is a distinctive dermatological manifestation that is commonly associated with sy...
Atopic Dermatitis: The Relationship Between Immune Mediators and Skin Lipid Barrier
Atopic Dermatitis: The Relationship Between Immune Mediators and Skin Lipid Barrier
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is prevalent worldwide with complex etiology. Skin barr...
Macrophage-Centric Immunometabolic Crosstalk in Alopecia Areata Pathogenesis: Mechanisms and Therapeutic Implications
Macrophage-Centric Immunometabolic Crosstalk in Alopecia Areata Pathogenesis: Mechanisms and Therapeutic Implications
Although alopecia areata (AA) is recognized as a hair loss disorder stemming from the dysregulation of cutaneous immune ho...
Sex Bias in Systemic Sclerosis: from Clinical to Immunological Differences
Sex Bias in Systemic Sclerosis: from Clinical to Immunological Differences
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvasculopathy, extensive fibrosis, and autoa...
Allergic Rhinitis is Associated with Increased Suicidality: A Systematic Review and Meta-Analysis
Allergic Rhinitis is Associated with Increased Suicidality: A Systematic Review and Meta-Analysis
Allergic rhinitis (AR) is a common inflammatory condition affecting millions globally. Emerging evidence suggests a potent...
IL-17-Related Pathways and Myeloid Cell Function are Involved in the Mechanism of Sublingual Immunotherapy with for Seasonal Allergic Rhinitis
IL-17-Related Pathways and Myeloid Cell Function are Involved in the Mechanism of Sublingual Immunotherapy with for Seasonal Allergic Rhinitis
The mechanisms underlying immune tolerance induction during sublingual immunotherapy (SLIT) of seasonal allergic rhinitis ...
Recombinant BCG Expressing IL-12 as A Novel Immunomodulatory Strategy for Allergic Asthma: Opportunities and Challenges
Recombinant BCG Expressing IL-12 as A Novel Immunomodulatory Strategy for Allergic Asthma: Opportunities and Challenges
Allergic asthma is a chronic respiratory disorder driven by a T helper type 2 (Th2)-mediated immune response that involves...
B Cell Tolerance and Obstetric Antiphospholipid Syndrome
B Cell Tolerance and Obstetric Antiphospholipid Syndrome
Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disorder characterized by antiphospholipid antibody-mediated i...
Promising Targeted Therapies for Hemophagocytic Lymphohistiocytosis: A Translational Perspective Based on Immunopathology
Promising Targeted Therapies for Hemophagocytic Lymphohistiocytosis: A Translational Perspective Based on Immunopathology
Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening hyperinflammatory disorder characterized by dysr...
The Immunology of Psoriasis—Current Concepts in Pathogenesis
The Immunology of Psoriasis—Current Concepts in Pathogenesis
Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-remitting course. The last decade...
Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Tropomyosin has been identified as the major cross-reactive shellfish allergen, but recent studies showed the presence of ...
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
This systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases ...
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway...
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate immune cell functions, particularly m...
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
The role of abnormal epigenetic modifications, particularly DNA methylation, in the pathogenesis of autoimmune rheumatic d...
Down Syndrome and Autoimmune Disease
Down Syndrome and Autoimmune Disease
Down syndrome is the most common genetic cause of intellectual disability and has previously been associated with a variet...
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Autoimmune diseases (AIDs) are complex in etiology and diverse in classification but clinically show similar symptoms such...
Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics
Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics
Fibroblasts are crucial components of the skin structure. They were traditionally believed to maintain the skin’s st...
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic dermatitis and psoriasis are common chronic inflammatory diseases of high incidence that share some clinical featur...
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory...
Fungal Head and Neck Dermatitis: Current Understanding and Management
Fungal Head and Neck Dermatitis: Current Understanding and Management
Head and neck dermatitis (HND) is a form of atopic dermatitis (AD) that affects the seborrheic areas of the body and cause...
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen-based diagnostics are essential in the management algorithm of allergic diseases. Unlike systemic allergy, where ...
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