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Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
According to official statistics, cancer remains the main reason of death and over 50% of patients with cancer receive rad...
Asymmetric dimethylarginine induces maladaptive function of the blood-brain barrier
Asymmetric dimethylarginine induces maladaptive function of the blood-brain barrier
Growing body of evidence suggests that cardiovascular risk factor, asymmetric dimethylarginine (ADMA), can be implicated i...
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
IntroductionGenetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations ch...
The transcription elongation factors Spt4 and Spt5 control neural progenitor proliferation and are implicated in neuronal remodeling during Drosophila mushroom body development
The transcription elongation factors Spt4 and Spt5 control neural progenitor proliferation and are implicated in neuronal remodeling during Drosophila mushroom body development
Spt4 and Spt5 form the DRB sensitivity inducing factor (DSIF) complex that regulates transcription elongation at multiple ...
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
Neurological disorders are being increasingly recognized as major causes of death and disability around the world. Neurolo...
Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease
Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease
This article reviews the latest research progress on the role of mitochondrial autophagy receptor FUN14 domain containing ...
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
IntroductionIntestinal stem cells (ISCs) are crucial for tissue repair and homeostasis because of their ability to self-re...
DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism
DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism
IntroductionProtein O-GlcNAcylation is a dynamic post-translational modification involved in major cellular processes and ...
Notch signaling regulates pulmonary fibrosis
Notch signaling regulates pulmonary fibrosis
Pulmonary fibrosis is a progressive interstitial lung disease associated with aging. The pathogenesis of pulmonary fibrosi...
Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection
Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection
IntroductionRetinal diseases significantly impact patients’ quality of life and increase social medical costs. Optical coh...
Polysaccharide-based hydrogels for cartilage regeneration
Polysaccharide-based hydrogels for cartilage regeneration
Cartilage defect is one of the common tissue defect clinical diseases and may finally lead to osteoarthritis (OA) which th...
The dual role of autophagy in suppressing and promoting hepatocellular carcinoma
The dual role of autophagy in suppressing and promoting hepatocellular carcinoma
The 5-year survival rate for hepatocellular carcinoma (HCC), a deadly form of liver cancer, is quite low. Although drug th...
Development of a transformer-based deep learning algorithm for diabetic peripheral neuropathy classification using corneal confocal microscopy images
Development of a transformer-based deep learning algorithm for diabetic peripheral neuropathy classification using corneal confocal microscopy images
BackgroundDiabetic peripheral neuropathy (DPN) is common and can go unnoticed until it is firmly developed. This study aim...
PD-1 inhibitor sintilimab treated patients with metastatic triple-negative breast cancer
PD-1 inhibitor sintilimab treated patients with metastatic triple-negative breast cancer
PurposeTriple-negative breast cancer (TNBC) is a highly challenging subtype due to a unique tumor microenvironment. Severa...
Integrating clinical and genomic landscape analysis of perineural invasion identify ACTA1 as an oncogene for oral squamous cell carcinoma
Integrating clinical and genomic landscape analysis of perineural invasion identify ACTA1 as an oncogene for oral squamous cell carcinoma
BackgroundPerineural invasion (PNI) has been shown to be a key pathological feature of several types of cancer, including ...
Corrigendum: A role for TRPC3 in mammalian testis development
Corrigendum: A role for TRPC3 in mammalian testis development
Corrigendum on: Ming, Z., Bagheri-Fam, S., Frost, E. R., Ryan, J. M., & Harley, V. R. (2024). A role for TRPC3 in ...
Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin
Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin
IntroductionCells generate mechanical forces mainly through myosin motor activity on the actin cytoskeleton. In C. elegans...
Modification of Lhx2 activity for ex vivo amplification of human iPSC-derived hematopoietic stem/progenitor cells
Modification of Lhx2 activity for ex vivo amplification of human iPSC-derived hematopoietic stem/progenitor cells
Hematopoietic stem cells (HSCs) obtained from patient-derived human induced pluripotent stem cells (iPSCs) are a promising...
Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors
Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors
IntroductionThe changing composition of non-cell autonomous circulating factors in blood as humans age is believed to play...
RNA-binding proteins in bone pathophysiology
RNA-binding proteins in bone pathophysiology
Bone remodelling is a highly regulated process that maintains mineral homeostasis and preserves bone integrity. During thi...
Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes
Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the m...
Corrigendum: ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells
Corrigendum: ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells
Ryo Niwa1,2Kouji Sakai3,4*Mandy Siu Yu Lung1†Tomoko Matsumoto1Ryuta Mikawa2,5Shotaro Maehana6,7Masato Suzuki8Yuki Yamamoto...
A novel perspective of calvarial development: the cranial morphogenesis and differentiation regulated by dura mater
A novel perspective of calvarial development: the cranial morphogenesis and differentiation regulated by dura mater
There are lasting concerns on calvarial development because cranium not only accommodates the growing brain, but also safe...
The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis
The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis
COVID-19 patients often suffer from post-COVID-19 acute sequelae (PASC). Pulmonary fibrosis has the most significant long-...
The progress of induced pluripotent stem cells derived from pigs: a mini review of recent advances
The progress of induced pluripotent stem cells derived from pigs: a mini review of recent advances
Pigs (Sus scrofa) are widely acknowledged as an important large mammalian animal model due to their similarity to human ph...
Extremely high spatiotemporal resolution microscopy for live cell imaging by single photon counting, noise elimination, and a novel restoration algorithm based on probability calculation
Extremely high spatiotemporal resolution microscopy for live cell imaging by single photon counting, noise elimination, and a novel restoration algorithm based on probability calculation
Optical microscopy is essential for direct observation of dynamic phenomena in living cells. According to the classic opti...
Screening of potentially active compounds against rheumatoid arthritis in the Juan-Bi decoction using systems pharmacology and animal experiments
Screening of potentially active compounds against rheumatoid arthritis in the Juan-Bi decoction using systems pharmacology and animal experiments
Background: The Juan-Bi decoction (JBD) is a classic traditional Chinese medicines (TCMs) prescription for the treatment o...
Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration
Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration
Sialadenitis and sialadenitis-induced sialopathy are typically caused by obstruction of the salivary gland ducts. Atrophy ...
Roles of cerebrospinal fluid-contacting neurons as potential neural stem cells in the repair and regeneration of spinal cord injuries
Roles of cerebrospinal fluid-contacting neurons as potential neural stem cells in the repair and regeneration of spinal cord injuries
Cerebrospinal fluid-contacting neurons (CSF-cNs) represent a distinct group of interneurons characterized by their promine...
The evolutionary origins and ancestral features of septins
The evolutionary origins and ancestral features of septins
Septins are a family of membrane-associated cytoskeletal guanine-nucleotide binding proteins that play crucial roles in va...
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