Newman DJ, Cragg GM (2020) Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod 83:770–803. https://doi.org/10.1021/acs.jnatprod.9b01285

Article  CAS  PubMed  Google Scholar 

Domingo-Fernández D, Gadiya Y, Preto AJ, Krettler CA, Mubeen S, Allen A, Healey D, Colluru V (2024) Natural products have increased rates of clinical trial success throughout the drug development process. J Nat Prod 87:1844–1851. https://doi.org/10.1021/acs.jnatprod.4c00581

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horvath P, Aulner N, Bickle M, Davies AM, Nery ED, Ebner D, Montoya MC, Östling P, Pietiäinen V, Price LS, Shorte SL, Turcatti G, von Schantz C, Carragher NO (2016) Screening out irrelevant cell-based models of disease. Nat Rev Drug Discov 15:751–769. https://doi.org/10.1038/nrd.2016.175

Article  CAS  PubMed  Google Scholar 

Moffat JG, Vincent F, Lee JA, Eder J, Prunotto M (2017) Opportunities and challenges in phenotypic drug discovery: an industry perspective. Nat Rev Drug Discov 16:531–543. https://doi.org/10.1038/nrd.2017.111

Article  CAS  PubMed  Google Scholar 

Atanasov AG, Zotchev SB, Dirsch VM, International Natural Product Sciences Taskforce, Supuran CT (2021) Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov 20:200–216. https://doi.org/10.1038/s41573-020-00114-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH (2023) Artificial intelligence for natural product drug discovery. Nat Rev Drug Discov 22:895–916. https://doi.org/10.1038/s41573-023-00774-7

Article  CAS  PubMed  Google Scholar 

Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425–479. https://doi.org/10.1146/annurev.biochem.67.1.425

Article  CAS  PubMed  Google Scholar 

Voges D, Zwickl P, Baumeister W (1999) The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 68:1015–1068. https://doi.org/10.1146/annurev.biochem.68.1.1015

Article  CAS  PubMed  Google Scholar 

Pickart CM (2001) Mechanisms underlying ubiquitination. Annu Rev Biochem 70:503–533. https://doi.org/10.1146/annurev.biochem.70.1.503

Article  CAS  PubMed  Google Scholar 

Glickman MH, Ciechanover A (2002) The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82:373–428. https://doi.org/10.1152/physrev.00027.2001

Article  CAS  PubMed  Google Scholar 

Adams J (2003) Potential for proteasome inhibition in the treatment of cancer. Drug Discov Today 8:307–315. https://doi.org/10.1016/s1359-6446(03)02647-3

Article  CAS  PubMed  Google Scholar 

Thompson JL (2013) Carfilzomib: a second-generation proteasome inhibitor for the treatment of relapsed and refractory multiple myeloma. Ann Pharmacother 47:56–62. https://doi.org/10.1345/aph.1R561

Article  CAS  PubMed  Google Scholar 

Muz B, Ghazarian RN, Ou M, Luderer MJ, Kusdono HD, Azab AK (2016) Spotlight on ixazomib: potential in the treatment of multiple myeloma. Drug Des Devel Ther 10:217–226. https://doi.org/10.2147/DDDT.S93602

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsukamoto S, Tane K, Ohta T, Matsunaga S, Fusetani N, van Soest RW (2001) Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla. J Nat Prod 64:1576–1578. https://doi.org/10.1021/np010280b

Article  CAS  PubMed  Google Scholar 

Tsukamoto S, Yamashita K, Tane K, Kizu R, Ohta T, Matsunaga S, Fusetani N, Kawahara H, Yokosawa H (2004) Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53. Biol Pharm Bull 27:699–701. https://doi.org/10.1248/bpb.27.699

Article  CAS  PubMed  Google Scholar 

Tsukamoto S, Tatsuno M, van Soest RW, Yokosawa H, Ohta T (2003) New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp. J Nat Prod 66:1181–1185. https://doi.org/10.1021/np030120v

Article  CAS  PubMed  Google Scholar 

Aoki S, Yoshioka Y, Miyamoto Y, Higuchi K, Setiawan A, Murakami N, Chen ZS, Sumizawa T, Akiyama S, Kobayashi M (1998) Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia sp. Tetrahedron Lett 39:6303–6306. https://doi.org/10.1016/S0040-4039(98)01336-7

Article  CAS  Google Scholar 

Aoki S, Chen ZS, Higasiyama K, Setiawan A, Akiyama S, Kobayashi M (2001) Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells. Jpn J Cancer Res 92:886–895. https://doi.org/10.1111/j.1349-7006.2001.tb01177.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamakuma M, Kato H, Matsuo K, El-Desoky AH, Kawabata T, Losung F, Mangindaan REP, de Voogd NJ, Yokosawa H, Tsukamoto S (2014) 1-Hydroxyethylhalenaquinone: a new proteasome inhibitor from the marine sponge Xestospongia sp. Heterocycles 89:2605–2610. https://doi.org/10.3987/COM-14-13087

Article  CAS  Google Scholar 

El-Desoky AH, Kato H, Eguchi K, Kawabata T, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Yokosawa H, Tsukamoto S (2014) Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids from the Indonesian marine sponge Acanthostrongylophora ingens. J Nat Prod 77:1536–1540. https://doi.org/10.1021/np500290

Article  CAS  PubMed  Google Scholar 

Tsukamoto S, Hirota H, Imachi M, Fujimuro M, Onuki H, Ohta T, Yokosawa H (2005) Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus Aspergillus sp. Bioorg Med Chem Lett 15:191–194. https://doi.org/10.1016/j.bmcl.2004.10.012

Article  CAS  PubMed  Google Scholar 

Yamanokuchi R, Imada K, Miyazaki M, Kato H, Watanabe T, Fujimuro M, Saeki Y, Yoshinaga S, Terasawa H, Iwasaki N, Rotinsulu H, Losung F, Mangindaan RE, Namikoshi M, de Voogd NJ, Yokosawa H, Tsukamoto S (2012) Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus. Bioorg Med Chem 20:4437–4442. https://doi.org/10.1016/j.bmc.2012.05.044

Article  CAS  PubMed  Google Scholar 

Ushiyama S, Umaoka H, Kato H, Suwa Y, Morioka H, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Yokosawa H, Tsukamoto S (2012) Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa. J Nat Prod 75:1495–1499. https://doi.org/10.1021/np300352u

Article  CAS  PubMed  Google Scholar 

Nakamura Y, Kato H, Nishikawa T, Iwasaki N, Suwa Y, Rotinsulu H, Losung F, Maarisit W, Mangindaan RE, Morioka H, Yokosawa H, Tsukamoto S (2013) Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53–Hdm2 interaction. Org Lett 15:322–325. https://doi.org/10.1021/ol3032363

Article  CAS  PubMed  Google Scholar 

Yamaguchi M, Miyazaki M, Kodrasov MP, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Yokosawa H, Nicholson B, Tsukamoto S (2013) Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor. Bioorg Med Chem Lett 23:3884–3886. https://doi.org/10.1016/j.bmcl.2013.04.066

Article  CAS  PubMed  Google Scholar 

Tanokashira N, Kukita S, Kato H, Nehira T, Angkouw ED, Mangindaan REP, de Voogd NJ, Tsukamoto S (2016) Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani. Tetrahedron 72:5530–5540. https://doi.org/10.1016/j.tet.2016.07.045

Article  CAS