Al-Niaimi A, Dickson EL, Albertin C, Karnowski J, Niemi C, Spencer R, Shahzad MMK, Uppal S, Saha S, Rice L, Nally AM (2016) The impact of perioperative β blocker use on patient outcomes after primary cytoreductive surgery in high-grade epithelial ovarian carcinoma. Gynecol Oncol 143(3):521–525. https://doi.org/10.1016/J.YGYNO.2016.09.019

Article  CAS  PubMed  Google Scholar 

Ashmore J, Olsen H, Sørensen N, Thrasivoulou C, Ahmed A (2019) Wnts control membrane potential in mammalian cancer cells. J Physiol 597(24):5899–5914. https://doi.org/10.1113/JP278661

Article  CAS  PubMed  Google Scholar 

Barathova M, Grossmannova K, Belvoncikova P, Kubasova V, Simko V, Skubla R, Csaderova L, Pastorek J (2020) Impairment of hypoxia-induced CA IX by beta-blocker propranolol—impact on progression and metastatic potential of colorectal cancer cells. Int J Mol Sci 21(22):8760. https://doi.org/10.3390/IJMS21228760

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1(1):11–21. https://doi.org/10.1038/35036035

Article  CAS  PubMed  Google Scholar 

Botteri E, Munzone E, Rotmensz N, Cipolla C, De Giorgi V, Santillo B, Zanelotti A, Adamoli L, Colleoni M, Viale G, Goldhirsch A, Gandini S (2013) Therapeutic effect of β-blockers in triple-negative breast cancer postmenopausal women. Breast Cancer Res Treat 140(3):567–575. https://doi.org/10.1007/S10549-013-2654-3

Article  CAS  PubMed  Google Scholar 

Bucsek MJ, Qiao G, MacDonald CR, Giridharan T, Evans L, Niedzwecki B, Liu H, Kokolus KM, Eng JWL, Messmer MN, Attwood K, Abrams SI, Hylander BL, Repasky EA (2017) β-Adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8+ T cells and undermines checkpoint inhibitor therapy. Can Res 77(20):5639–5651. https://doi.org/10.1158/0008-5472.CAN-17-0546

Article  CAS  Google Scholar 

Caparica R, Bruzzone M, Agostinetto E, De Angelis C, Fêde Â, Ceppi M, de Azambuja E (2021) Beta-blockers in early-stage breast cancer: a systematic review and meta-analysis. ESMO Open. https://doi.org/10.1016/j.esmoop.2021.100066

Article  PubMed  PubMed Central  Google Scholar 

Cardwell CR, Pottegard A, Vaes E, Garmo H, Murray LJ, Brown C, Vissers PAJ, O’Rorke M, Visvanathan K, Cronin-Fenton D, De Schutter H, Lambe M, Powe DG, van Herk-Sukel MPP, Gavin A, Friis S, Sharp L, Bennett K (2016) Propranolol and survival from breast cancer: a pooled analysis of European breast cancer cohorts. Breast Cancer Res: BCR 18(1):119. https://doi.org/10.1186/s13058-016-0782-5

Carnet Le Provost K, Kepp O, Kroemer G, Bezu L (2023) Trial watch: beta-blockers in cancer therapy. Oncoimmunology 12(1):2284486. https://doi.org/10.1080/2162402X.2023.2284486

Article  PubMed  PubMed Central  Google Scholar 

Cavalu S, Saber S, Amer AE, Hamad RS, Abdel-Reheim MA, Elmorsy EA, Abdelhamid AM (2024) The multifaceted role of beta-blockers in overcoming cancer progression and drug resistance: Extending beyond cardiovascular disorders. FASEB J 38(13):e23813. https://doi.org/10.1096/FJ.202400725RR

Article  CAS  PubMed  Google Scholar 

Chang H, Lee SH (2023) Beta-adrenergic receptor blockers and hepatocellular carcinoma survival: a systemic review and meta-analysis. Clin Exp Med 23(3):853–858. https://doi.org/10.1007/s10238-022-00842-z

Article  CAS  PubMed  Google Scholar 

Childers WK, Hollenbeak CS, Cheriyath P (2015) β-Blockers reduce breast cancer recurrence and breast cancer death: a meta-analysis. Clin Breast Cancer 15(6):426–431. https://doi.org/10.1016/j.clbc.2015.07.001

Article  CAS  PubMed  Google Scholar 

Choi CH, Song T, Kim TH, Choi JK, Park JY, Yoon A, Lee YY, Kim TJ, Bae DS, Lee JW, Kim BG (2014) Meta-analysis of the effects of beta blocker on survival time in cancer patients. J Cancer Res Clin Oncol 140(7):1179–1188. https://doi.org/10.1007/s00432-014-1658-7

Article  CAS  PubMed  Google Scholar 

Coelho M, Squizzato A, Cassina N, Marino F, Ribeiro LV, Cosentino M (2020) Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis. Eur J Cancer Prevent: off J Eur Cancer Prevent Org (ECP) 29(4):306–314. https://doi.org/10.1097/CEJ.0000000000000544

Article  Google Scholar 

Cole SW, Sood AK (2011) Molecular Pathways: Beta-adrenergic signaling in cancer. Clin Cancer Res 18(5):1201. https://doi.org/10.1158/1078-0432.CCR-11-0641

Article  PubMed  PubMed Central  Google Scholar 

Dancey J (2010) mTOR signaling and drug development in cancer. Nat Rev Clin Oncol 7(4):209–219. https://doi.org/10.1038/NRCLINONC.2010.21

Article  CAS  PubMed  Google Scholar 

Duckett MM, Phung SK, Nguyen L, Khammanivong A, Dickerson E, Dusenbery K, Lawrence J (2020) The adrenergic receptor antagonists propranolol and carvedilol decrease bone sarcoma cell viability and sustained carvedilol reduces clonogenic survival and increases radiosensitivity in canine osteosarcoma cells. Veterinary Comparative Oncol 18(1):128–140. https://doi.org/10.1111/VCO.12560

Article  CAS  Google Scholar 

Fasolo A, Sessa C (2012) Targeting mTOR pathways in human malignancies. Curr Pharm des 18(19):2766–2777. https://doi.org/10.2174/138161212800626210

Article  CAS  PubMed  Google Scholar 

Guo YC, Chang CM, Hsu WL, Chiu SJ, Tsai YT, Chou YH, Hou MF, Wang JY, Lee MH, Tsai KL, Chang WC (2013) Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. Molecules 8(6):6584–6596

Google Scholar 

Gustafson MP, Lin Y, Bleeker JS, Warad D, Tollefson MK, Crispen PL, Bulur PA, Harrington SM, Laborde RR, Gastineau DA, Leibovich BC, Cheville JC, Kwon ED, Dietz AB (2015) Intratumoral CD14+ cells and circulating CD14+HLA-DRlo/neg monocytes correlate with decreased survival in patients with clear cell renal cell carcinoma. Clin Cancer Res: off J Am Assoc Cancer Res 21(18):4224–4233. https://doi.org/10.1158/1078-0432.CCR-15-0260

Article  CAS  Google Scholar 

Haider R, Ricon-Becker I, Radin A, Gutman M, Cole SW, Zmora O, Ben-Eliyahu S, Haldar R, Ricon-Becker I, Radin A, Gutman M, Cole SW, Zmora O, Ben-Eliyahu S (2020) Perioperative COX2 and β-adrenergic blockade improves biomarkers of tumor metastasis, immunity, and inflammation in colorectal cancer: a randomized controlled trial. Cancer 126(17):3991–4001. https://doi.org/10.1002/cncr.32950

Article  CAS  Google Scholar 

Haldar R, Shaashua L, Lavon H, Lyons YA, Zmora O, Sharon E, Birnbaum Y, Allweis T, Sood AK, Barshack I, Cole S, Ben-Eliyahu S (2018) Perioperative inhibition of beta-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome. Brain, Behavior, Immun 73:294–309

CAS  Google Scholar 

Heitz F, du Bois A, Harter P, Lubbe D, Kurzeder C, Vergote I, Plante M, Pfisterer J (2013) Impact of beta blocker medication in patients with platinum sensitive recurrent ovarian cancer-a combined analysis of 2 prospective multicenter trials by the AGO Study Group. NCIC-CTG EORTC-GCG. Gynecologic Oncol 129(3):463–466

CAS  Google Scholar 

Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JAC (2011) The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. https://doi.org/10.1136/BMJ.D5928

Article  PubMed  PubMed Central  Google Scholar 

Hiller JG, Perry NJ, Poulogiannis G, Riedel B, Sloan EK (2018) Perioperative events influence cancer recurrence risk after surgery. Nat Rev Clin Oncol 15(4):205–218. https://doi.org/10.1038/NRCLINONC.2017.194

Article  PubMed  Google Scholar 

Hiller JG, Cole SW, Crone EM, Byrne DJ, Shackleford DM, Pang JB, Henderson MA, Nightingale SS, Ho KM, Myles PS et al (2020) Preoperative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a phase II randomized trial. Clin Cancer Res 26(8):1803–1811

CAS  PubMed  Google Scholar 

Holmes WJM, Mishra A, Gorst C, Liew SH (2011) Propranolol as first-line treatment for rapidly proliferating infantile haemangiomas. J Plastic, Reconstructive Aesth Surg: JPRAS 64(4):445–451. https://doi.org/10.1016/J.BJPS.2010.07.009

Article  CAS  Google Scholar 

Howe LR, Brown AMC (2004) Wnt signaling and breast cancer. Cancer Biol Ther 3(1):36–41. https://doi.org/10.4161/CBT.3.1.561

Article  CAS  PubMed  Google Scholar 

Huettner FJ, Rooman I, Bouche G, Knebel P, Huesing J, Mihaljevic AL, Hackert T, Strobel O, Buechler MW, Diener MK (2020) Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: trial protocol of the phase-II randomised placebo controlled PROSPER trial. BMJ Open. https://doi.org/10.1136/bmjopen-2020-040406

Article  Google Scholar 

Issa N, Byers S, Dakshanamurthy S (2013) Drug repurposing: translational pharmacology, chemistry, computers and the clinic. Curr Top Med Chem 13(18):2328–2336. https://doi.org/10.2174/15680266113136660163

Article  CAS