Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, et al. Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol. 2010;9(11):1118–27.

Article  PubMed  Google Scholar 

Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG. Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease. Front Cell Neurosci. 2015;9:191.

Article  PubMed  PubMed Central  Google Scholar 

De Felice FG, Goncalves RA, Ferreira ST. Impaired insulin signalling and allostatic load in Alzheimer disease. Nat Rev Neurosci. 2022;23(4):215–30.

Article  PubMed  Google Scholar 

Huang Z, Jordan JD, Zhang Q. Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease. Transl Neurodegener. 2023;12(1):25.

Article  PubMed  PubMed Central  Google Scholar 

Yan Y, Dominguez S, Fisher DW, Dong H. Sex differences in chronic stress responses and Alzheimer’s disease. Neurobiol Stress. 2018;8:120–6.

Article  PubMed  PubMed Central  Google Scholar 

Kim JJ, Song EY, Kosten TA. Stress effects in the hippocampus: synaptic plasticity and memory. Stress. 2006;9(1):1–11.

Article  CAS  PubMed  Google Scholar 

Cabbia R, Consoli A, Suchecki D. Association of 24 h maternal deprivation with a saline injection in the neonatal period alters adult stress response and brain monoamines in a sex-dependent fashion. Stress. 2018;21(4):333–46.

Article  CAS  PubMed  Google Scholar 

Miragaia AS, de Oliveira Wertheimer GS, Consoli AC, Cabbia R, Longo BM, Girardi CEN, et al. Maternal deprivation increases anxiety- and depressive-like behaviors in an age-dependent fashion and reduces neuropeptide Y expression in the amygdala and hippocampus of male and female young adult rats. Front Behav Neurosci. 2018;12:159.

Article  PubMed  PubMed Central  Google Scholar 

Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, et al. The major risk factors for Alzheimer’s disease: age, sex, and genes modulate the microglia response to abeta plaques. Cell Rep. 2019;27(4):1293-306.e6.

Article  CAS  PubMed  Google Scholar 

Zhu D, Montagne A, Zhao Z. Alzheimer’s pathogenic mechanisms and underlying sex difference. Cell Mol Life Sci. 2021;78(11):4907–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luine V. Sex differences in chronic stress effects on memory in rats. Stress. 2002;5(3):205–16.

Article  CAS  PubMed  Google Scholar 

Luine VN, Spencer RL, McEwen BS. Effects of chronic corticosterone ingestion on spatial memory performance and hippocampal serotonergic function. Brain Res. 1993;616(1–2):65–70.

Article  CAS  PubMed  Google Scholar 

Bianco A, Antonacci Y, Liguori M. Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities. Int J Mol Sci. 2023;24(7):6354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fisher DW, Bennett DA, Dong H. Sexual dimorphism in predisposition to Alzheimer’s disease. Neurobiol Aging. 2018;70:308–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farrell MR, Holland FH, Shansky RM, Brenhouse HC. Sex-specific effects of early life stress on social interaction and prefrontal cortex dendritic morphology in young rats. Behav Brain Res. 2016;310:119–25.

Article  CAS  PubMed  Google Scholar 

Bories C, Guitton MJ, Julien C, Tremblay C, Vandal M, Msaid M, et al. Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer’s disease. PLoS ONE. 2012;7(9): e46111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paolillo EW, You M, Gontrum E, Saloner R, Gaynor LS, Kramer JH, et al. Sex differences in the relationship between perceived stress and cognitive trajectories. Am J Geriatr Psychiatry. 2023;31(6):401–10.

Article  PubMed  Google Scholar 

Garvin MM, Bolton JL. Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms. Front Behav Neurosci. 2022;16:1013865.

Article  PubMed  PubMed Central  Google Scholar 

Noschang CG, Krolow R, Fontella FU, Arcego DM, Diehl LA, Weis SN, et al. Neonatal handling impairs spatial memory and leads to altered nitric oxide production and DNA breaks in a sex specific manner. Neurochem Res. 2010;35(7):1083–91.

Article  CAS  PubMed  Google Scholar 

Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, et al. Interaction of amyloid-beta (Abeta) oligomers with neurexin 2alpha and neuroligin 1 mediates synapse damage and memory loss in mice. J Biol Chem. 2017;292(18):7327–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nat Med. 2019;25(1):165–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ribeiro FC, Cozachenco D, Heimfarth L, Fortuna JTS, de Freitas GB, de Sousa JM, et al. Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice. Commun Biol. 2023;6(1):1127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, et al. Abeta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem. 2007;282(15):11590–601.

Article  PubMed  Google Scholar 

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, et al. Memantine rescues transient cognitive impairment caused by high-molecular-weight abeta oligomers but not the persistent impairment induced by low-molecular-weight oligomers. J Neurosci. 2013;33(23):9626–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, et al. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s beta-amyloid oligomers in mice and monkeys. Cell Metab. 2013;18(6):831–43.

Article  CAS  PubMed  Google Scholar 

Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, et al. Amyloid-beta oligomers link depressive-like behavior and cognitive deficits in mice. Mol Psychiatry. 2013;18(10):1053–4.

Article  CAS  PubMed  Google Scholar 

Laursen SE, Belknap JK. Intracerebroventricular injections in mice: some methodological refinements. J Pharmacol Methods. 1986;16(4):355–7.

Article  CAS  PubMed  Google Scholar 

Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, et al. Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer’s amyloid-beta oligomers in mice. J Neurosci. 2016;36(48):12106–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suman PR, Souza LS, Kincheski GC, Melo HM, Machado MN, Carvalho GMC, et al. Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice. J Neuroinflamm. 2022;19(1):303.

Article  CAS