Rein B, Ma K, Yan Z. A standardized social preference protocol for measuring social deficits in mouse models of autism. Nat Protoc. 2020;15(10):3464–77.
Article CAS PubMed PubMed Central Google Scholar
Nadeem A, et al. Toll-like receptor 4 signaling is associated with upregulated NADPH oxidase expression in peripheral T cells of children with autism. Brain Behav Immunity. 2017;61:146–54.
Ebrahimi Meimand S, Rostam-Abadi Y, Rezaei N. Autism spectrum disorders and natural killer cells: a review on pathogenesis and treatment. Expert Rev Clin Immunol. 2021;17(1):27–35.
Article CAS PubMed Google Scholar
Sabra A, Aderbal Filho S, Selma S. Autism: etiology, epidemiology, pathology, clinical aspects and treatment. Autism Open Access. 2020;10(3):253.
Bergeron JD, et al. White matter injury and autistic-like behavior predominantly affecting male rat offspring exposed to group B streptococcal maternal inflammation. Dev Neurosci. 2013;35(6):504–15.
Article CAS PubMed Google Scholar
Hsiao EY, et al. Modeling an autism risk factor in mice leads to permanent immune dysregulation. Proc Natl Acad Sci USA. 2012;109(31):12776–81.
Article CAS PubMed PubMed Central Google Scholar
Lucas K, Maes M. Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol Neurobiol. 2013;48(1):190–204.
Article CAS PubMed PubMed Central Google Scholar
Bueno BG, et al. Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases. Neurosci Biobehav Rev. 2016;64:134–47.
Vallabhapurapu S, Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annu Rev Immunol. 2009;27:693–733.
Article CAS PubMed Google Scholar
Hsieh HL, Yang CM. Role of redox signaling in neuroinflammation and neurodegenerative diseases. Biomed Res Int. 2013;2013(1): 484613.
PubMed PubMed Central Google Scholar
Yang CM, et al. Multiple factors from bradykinin-challenged astrocytes contribute to the neuronal apoptosis: involvement of astroglial ROS, MMP-9, and HO-1/CO system. Mol Neurobiol. 2013;47(3):1020–33.
Article CAS PubMed Google Scholar
Tummers B, Green DR. Caspase-8: regulating life and death. Immunol Rev. 2017;277(1):76–89.
Article CAS PubMed PubMed Central Google Scholar
Heckmann BL, Tummers B, Green DR. Crashing the computer apoptosis vs. necroptosis in neuroinflammation. Cell Death Differ. 2019;26(1):41–52.
Emberti Gialloreti L, Curatolo P. Autism spectrum disorder: why do we know so little? Front Neurol. 2018;9:394207.
Mano-Sousa BJ, et al. Effects of risperidone in autistic children and young adults: a systematic review and meta-analysis. Curr Neuropharmacol. 2021;19(4):538–52.
Article CAS PubMed PubMed Central Google Scholar
Marchezan J, et al. Immunological dysfunction in autism spectrum disorder: a potential target for therapy. NeuroImmunoModulation. 2019;25(5–6):300–19.
Sharma SR, Gonda X, Tarazi FI. Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther. 2018;190:91–104.
Article CAS PubMed Google Scholar
Kandezi N, et al. Novel insight to neuroprotective potential of curcumin: a mechanistic review of possible involvement of mitochondrial biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF signaling pathways. Int J Mol Cell Med. 2020;9(1):1–32.
CAS PubMed PubMed Central Google Scholar
Pella D, Rybar R, Mechirova V. Pleiotropic effects of statins. Acta Cardiol Sin. 2005;21(4):190.
Katsargyris A, et al. Statin treatment is associated with reduced toll-like receptor 4 immunohistochemical expression on carotid atherosclerotic plaques: a novel effect of statins. Vascular. 2011;19(6):320–6.
Pan HC, et al. Neuroprotective effect of atorvastatin in an experimental model of nerve crush injury. Neurosurgery. 2010;67(2):376–88 (discussion 388–9).
Chen JH, et al. An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage. Neural Regen Res. 2020;15(10):1947–54.
Article CAS PubMed PubMed Central Google Scholar
Kho AR, et al. The effects of atorvastatin on global cerebral ischemia-induced neuronal death. Int J Mol Sci. 2021;22(9):4385.
Article CAS PubMed PubMed Central Google Scholar
Yu L, et al. Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats. FASEB J. 2022;36(4): e22263.
Article CAS PubMed Google Scholar
Yang SS, et al. Atorvastatin decreases Toll-like receptor 4 expression and downstream signaling in human monocytic leukemia cells. Cell Immunol. 2012;279(1):96–102.
Article CAS PubMed Google Scholar
Denucci BL, et al. Current knowledge, challenges, new perspectives of the study, and treatments of Autism Spectrum Disorder. Reprod Toxicol. 2021;106:82–93.
Xu X, et al. Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury. J Neuroinflammation. 2017;14(1):167.
Article PubMed PubMed Central Google Scholar
Mabunga DF, et al. Exploring the validity of valproic acid animal model of autism. Exp Neurobiol. 2015;24(4):285–300.
Article PubMed PubMed Central Google Scholar
Nicolini C, Fahnestock M. The valproic acid-induced rodent model of autism. Exp Neurol. 2018;299(Pt A):217–27.
Article CAS PubMed Google Scholar
Chaliha D, et al. A systematic review of the valproic-acid-induced rodent model of autism. Dev Neurosci. 2020;42(1):12–48.
Article CAS PubMed Google Scholar
Atia AA, et al. The comparative effectiveness of metformin and risperidone in a rat model of valproic acid-induced autism, potential role for enhanced autophagy. Psychopharmacology. 2023;240(6):1313–32.
Article CAS PubMed PubMed Central Google Scholar
Roullet FI, Lai JK, Foster JA. In utero exposure to valproic acid and autism—a current review of clinical and animal studies. Neurotoxicol Teratol. 2013;36:47–56.
Article CAS PubMed Google Scholar
Mirza R, Sharma B. Benefits of fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. Brain Res Bull. 2019;147:36–46.
Article CAS PubMed Google Scholar
Markram K, et al. Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology. 2008;33(4):901–12.
Comments (0)