HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia

Kadye T, Jamil MS, Johnson C et al (2024) Country uptake of WHO recommendations on differentiated HIV testing services approaches: a global policy review. BMJ Open 14:e058098. https://doi.org/10.1136/bmjopen-2021-058098

Article  PubMed  PubMed Central  Google Scholar 

Bosh KA, Hall HI, Eastham L et al (2021) Estimated annual number of HIV infections united States, 1981–2019. MMWR Morb Mortal Wkly Rep 70:801–806. https://doi.org/10.15585/mmwr.mm7022a1

Article  PubMed  PubMed Central  Google Scholar 

Anderson EM, Maldarelli F (2018) The role of integration and clonal expansion in HIV infection: live long and prosper. Retrovirology 15:71. https://doi.org/10.1186/s12977-018-0448-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mambule I, Norcross C, Achieng Ombajo L et al (2024) Two-drug regimens for the treatment of HIV in Africa. Lancet HIV 11:e419–e426. https://doi.org/10.1016/S2352-3018(24)00061-4

Article  CAS  PubMed  Google Scholar 

Mendicino CCP, Moreira Costa AA, Da Silva GJ et al (2022) Metabolic comorbidities and systemic arterial hypertension: the challenge faced by HIV patients on long-term use of antiretroviral therapy. Hosp Pract 50:75–81. https://doi.org/10.1080/21548331.2022.2030564

Article  CAS  Google Scholar 

Hoang THL, Nguyen VM, Adermark L et al (2024) Factors influencing tobacco smoking and cessation among people living with HIV: A systematic review and Meta-analysis. AIDS Behav 28:1858–1881. https://doi.org/10.1007/s10461-024-04279-1

Article  PubMed  PubMed Central  Google Scholar 

Asfar T, Perez A, Shipman P et al (2021) National estimates of prevalence, Time-Trend, and correlates of smoking in US people living with HIV (NHANES 1999–2016). Nicotine Tob Res 23:1308–1317. https://doi.org/10.1093/ntr/ntaa277

Article  PubMed  PubMed Central  Google Scholar 

Nazari I, Feinstein MJ (2024) Evolving mechanisms and presentations of cardiovascular disease in people with HIV: implications for management. Clin Microbiol Rev 37:e0009822. https://doi.org/10.1128/cmr.00098-22

Article  CAS  PubMed  Google Scholar 

Haque S, Kodidela S, Gerth K et al (2020) Extracellular vesicles in Smoking-Mediated HIV pathogenesis and their potential role in biomarker discovery and therapeutic interventions. Cells 9:864. https://doi.org/10.3390/cells9040864

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durazzo TC, Rothlind JC, Cardenas VA et al (2007) Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology. Alcohol 41:489–501. https://doi.org/10.1016/j.alcohol.2007.07.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thompson LJ-P, Genovese J, Hong Z et al (2024) HIV-Associated neurocognitive disorder: A look into cellular and molecular pathology. Int J Mol Sci 25:4697. https://doi.org/10.3390/ijms25094697

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fitting S, Ignatowska-Jankowska BM, Bull C et al (2013) Synaptic dysfunction in the Hippocampus accompanies learning and memory deficits in human immunodeficiency virus Type-1 Tat Transgenic mice. Biol Psychiatry 73:443–453. https://doi.org/10.1016/j.biopsych.2012.09.026

Article  CAS  PubMed  Google Scholar 

Sreeram S, Ye F, Garcia-Mesa Y et al (2022) The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder. Trends Immunol 43:630–639. https://doi.org/10.1016/j.it.2022.06.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams KC, Corey S, Westmoreland SV et al (2001) Perivascular macrophages are the primary cell type productively infected by Simian immunodeficiency virus in the brains of macaques. J Exp Med 193:905–916. https://doi.org/10.1084/jem.193.8.905

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borrajo López A, Penedo MA, Rivera-Baltanas T et al (2021) Microglia: the real foe in HIV-1-Associated. Neurocognitive Disorders? Biomedicines 9:925. https://doi.org/10.3390/biomedicines9080925

Article  CAS  PubMed  Google Scholar 

Giunta B, Ehrhart J, Obregon DF et al (2011) Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders. Mol Brain 4:23. https://doi.org/10.1186/1756-6606-4-23

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu L, Gerard NP, Wyatt R et al (1996) CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384:179–183. https://doi.org/10.1038/384179a0

Article  CAS  PubMed  Google Scholar 

Capó-Vélez CM, Morales-Vargas B, García-González A et al (2018) The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders. Sci Rep 8:1829. https://doi.org/10.1038/s41598-018-20271-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strober W (1997) Trypan blue exclusion test of cell viability. CP Immunol 21. https://doi.org/10.1002/0471142735.ima03bs21

Lewis TL, Turi GF, Kwon S-K et al (2016) Progressive decrease of mitochondrial motility during maturation of cortical axons in vitro and in vivo. Curr Biol 26:2602–2608. https://doi.org/10.1016/j.cub.2016.07.064

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rizzo MA, Davidson MW, Piston DW (2009) Fluorescent protein tracking and detection: fluorescent protein structure and color variants. https://doi.org/10.1101/pdb.top63. Cold Spring Harb Protoc 2009:pdb.top63

Graur A, Sinclair P, Schneeweis AK et al (2023) The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway. Sci Rep 13:11434. https://doi.org/10.1038/s41598-023-38637-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinclair P, Kabbani N (2022) Nicotinic receptor components of amyloid beta 42 proteome regulation in human neural cells. PLoS ONE 17:e0270479. https://doi.org/10.1371/journal.pone.0270479

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinclair P, Baranova A, Kabbani N (2021) Mitochondrial disruption by amyloid Beta 42 identified by proteomics and pathway mapping. Cells 10:2380. https://doi.org/10.3390/cells10092380

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, Gable AL, Nastou KC et al (2021) The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res 49:D605–D612. https://doi.org/10.1093/nar/gkaa1074

Article  CAS  PubMed  Google Scholar 

Wickham H (2016) ggplot2: Elegant graphics for data analysis

Stelzer G, Rosen N, Plaschkes I et al (2016):1.30.1–. Curr Protoc Bioinf 54. https://doi.org/10.1002/cpbi.5. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses

Sherman BT, Hao M, Qiu J et al (2022) DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res 50:W216–W221. https://doi.org/10.1093/nar/gkac194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44–57. https://doi.org/10.1038/nprot.2008.211

Article  CAS  PubMed  Google Scholar 

Chaudhry A, Shi R, Luciani DS (2020) A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic β-cells. Am J Physiology-Endocrinology Metabolism 318:E87–E101. https://doi.org/10.1152/ajpendo.00457.2019

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