Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia

Zhang ZA, Sun YF, Yuan ZY, Wang L, Dong Q, Zhou Y, Zheng G, Aschner M, Zou YK, Luo WJ (2022) Insight into the effects of high-altitude hypoxic exposure on learning and memory. Oxid Med Cell Longev 2022:4163188

PubMed  PubMed Central  Google Scholar 

Nuss R (2022) Medical conditions and high-altitude travel. New Engl J Med 386:1866–1866

Article  PubMed  Google Scholar 

Li Y, Zhu J, Liu Y, Chen X, Lei S, Li L, Jiang B, Tan L, Yu S, Zhao Y (2016) Glycogen synthase kinase 3beta Influences injury following cerebral ischemia/reperfusion in rats. Int J Biol Sci 12:518–531

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moral Y, Robertson NJ, Goni-de-Cerio F, Alonso-Alconada D (2019) Neonatal hypoxia-ischemia: cellular and molecular brain damage and therapeutic modulation of neurogenesis. Rev Neurol 68:23–36

CAS  PubMed  Google Scholar 

Carissimi A, Martinez D, Kim LJ, Fiori CZ, Vieira LR, Rosa DP, Pires GN (2018) Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice. Braz J Psychiatry 40:376–381

Article  PubMed  PubMed Central  Google Scholar 

Bao H, Li R, He M, Kang D, Zhao L (2019) DTI study on brain structure and cognitive function in patients with chronic mountain sickness. Sci Rep 9:19334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosko L, Smith VN, Yamazaki R, Huang JK (2019) Oligodendrocyte bioenergetics in health and disease. Neuroscientist 25:334–343

Article  CAS  PubMed  Google Scholar 

Funfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Mobius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Moraes CT, Frahm J, Goebbels S, Nave KA (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 485:517–521

Article  PubMed  PubMed Central  Google Scholar 

Luo M, Yin Y, Li D, Tang W, Liu Y, Pan L, Yu L, Tan B (2021) Neuronal activity-dependent myelin repair promotes motor function recovery after contusion spinal cord injury. Brain Res Bull 166:73–81

Article  CAS  PubMed  Google Scholar 

Su H, Luo H, Wang Y, Zhao Q, Zhang Q, Zhu Y, Pan L, Liu Y, Yang C, Yin Y, Tan B (2024) Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator-activated receptor gamma coactivator 1 alpha. Glia 72:607–624

Article  CAS  PubMed  Google Scholar 

von Bernhardi JE, Dimou L (2022) Oligodendrogenesis is a key process for cognitive performance improvement induced by voluntary physical activity. Glia 70:1052–1067

Article  Google Scholar 

Jensen SK, Michaels NJ, Ilyntskyy S, Keough MB, Kovalchuk O, Yong VW (2018) Multimodal enhancement of remyelination by exercise with a pivotal role for oligodendroglial PGC1 alpha. Cell Rep 24:3167–3179

Article  CAS  PubMed  Google Scholar 

Sohrabi P, Parnow A, Jalili C (2023) Treadmill aerobic training improve beam-walking test, up-regulate expression of main proteins of myelin and myelination in the hippocampus of cuprizone-fed mice. Neurosci Lett 792:136936

Article  CAS  PubMed  Google Scholar 

Jiang T, Luo J, Pan XN, Zheng HQ, Yang HC, Zhang LY, Hu XQ (2021) Physical exercise modulates the astrocytes polarization, promotes myelin debris clearance and remyelination in chronic cerebral hypoperfusion rats. Life Sci 278:119526

Article  CAS  PubMed  Google Scholar 

Wu YL, Deng FF, Wang J, Liu YP, Zhou W, Qu L, Cheng M (2020) Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus. Behav Brain Res 386:112599

Article  CAS  PubMed  Google Scholar 

Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA (2012) Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 78:1323–1329

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhan Z, Pan L, Zhu Y, Wang Y, Zhao Q, Liu Y, Li S, Wang H, Yang C, Yu L, Yin Y, Tan B (2023) Moderate-intensity treadmill exercise promotes mTOR-dependent motor cortical neurotrophic factor expression and functional recovery in a murine model of crush spinal cord injury (SCI). Mol Neurobiol 60:960–978

Article  CAS  PubMed  Google Scholar 

Liu Y, Chu JMT, Ran Y, Zhang Y, Chang RCC, Wong GTC (2022) Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders. J Neuroinflammation 19:150

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, Zhang J, Wu S, Qin S, Zheng Y, Xia C, Geng H, Yao J, Deng L (2022) The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor gamma coactivator-1alpha. Anim Nutr 11:121–131

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin SW, Lee GH, Kim JY, Kim CY, Choo YM, Cho W, Han EH, Hwang YP, Kim YA, Jeong HG (2022) Effect of porcine whole blood protein hydrolysate on slow-twitch muscle fiber expression and mitochondrial biogenesis via the AMPK/SIRT1 pathway. Int J Mol Sci 23:1229

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang C, Han B, Li Q, Han R, Hao J (2019) Up-regulation of PGC-1alpha in neurons protects against experimental autoimmune encephalomyelitis. Faseb J 33:14811–14824

Article  CAS  PubMed  Google Scholar 

Cowell RM, Blake KR, Russell JW (2007) Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain. J Comp Neurol 502:1–18

Article  CAS  PubMed  Google Scholar 

Lu F, Ferriero DM, Jiang X (2022) Cholesterol in brain development and perinatal brain injury: more than a building block. Curr Neuropharmacol 20:1400–1412

Article  CAS  PubMed  PubMed Central  Google Scholar 

Voskuhl RR, Itoh N, Tassoni A, Matsukawa MA, Ren E, Tse V, Jang E, Suen TT, Itoh Y (2019) Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis. Proc Natl Acad Sci USA 116:10130–10139

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miron VE, Zehntner SP, Kuhlmann T, Ludwin SK, Owens T, Kennedy TE, Bedell BJ, Antel JP (2009) Statin therapy inhibits remyelination in the central nervous system. Am J Pathol 174:1880–1890

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magalon K, Zimmer C, Cayre M, Khaldi J, Bourbon C, Robles I, Tardif G, Viola A, Pruss RM, Bordet T, Durbec P (2012) Olesoxime accelerates myelination and promotes repair in models of demyelination. Ann Neurol 71:213–226

Article  CAS  PubMed  Google Scholar 

Xiang Z, Valenza M, Cui L, Leoni V, Jeong HK, Brilli E, Zhang J, Peng Q, Duan W, Reeves SA, Cattaneo E, Krainc D (2011) Peroxisome-proliferator-activated receptor gamma coactivator 1 alpha contributes to dysmyelination in experimental models of Huntington’s disease. J Neurosci 31:9544–9553

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahmati M, Kazemi A (2019) Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus. Gene 692:185–194

Article  CAS  PubMed  Google Scholar 

Vieira RP, Claudino RC, Duarte ACS, Santos ABG, Perini A, Faria Neto HCC, Mauad T, Martins MA, Dolhnikoff M, Carvalh CRF (2007) Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice. Am J Resp Crit Care 176:871–877

Article 

Comments (0)

No login
gif