World Health Organitation. Child Maltreatment. 2024. p. https://www.who.int/news-room/fact-sheets/detail/child-maltreatment

Baram TZ, Solodkin A, Davis E, Stern H, Obenaus A, Sandman CA et al (2012) Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry 169(9):907–915

Article  PubMed  PubMed Central  Google Scholar 

Raineki C, Cortés M, Belnoue L, Sullivan R (2012) Effects of early-life abuse differ across development: infant social behavior deficits are followed by adolescent depressive-like behaviors mediated by the amygdala. J Neurosci 32(22):7758–7765

Article  CAS  PubMed  PubMed Central  Google Scholar 

Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T (2012) The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS Med 9(11):e1001349

Article  PubMed  PubMed Central  Google Scholar 

Glynn LM, Baram TZ (2019) The influence of unpredictable, fragmented parental signals on the developing brain. Front Neuroendocrinol 53:100736

Article  PubMed  PubMed Central  Google Scholar 

Shonkoff JP, Garner AS, Siegel BS, Dobbins MI, Earls MF, McGuinn L et al (2012) The lifelong effects of early childhood adversity and toxic stress. Pediatrics 129(1):e232–e246

Article  PubMed  Google Scholar 

Felitti VJ (2002) The relation between adverse childhood experiences and adult health: turning gold into lead. Perm J 6(1):44–47

PubMed  PubMed Central  Google Scholar 

Anda RF, Felitti VJ, Bremner JD, Walker JD, Whitfield C, Perry BD et al (2006) The enduring effects of abuse and related adverse experiences in childhood: a convergence of evidence from neurobiology and epidemiology. Perm J 24(2):1–26

Google Scholar 

Juruena MF, Bourne M, Young AH, Cleare AJ (2021) Hypothalamic-pituitary-adrenal axis dysfunction by early life stress. Neurosci Lett 759:136037

Article  CAS  PubMed  Google Scholar 

Bolton JL, Short AK, Simeone KA, Daglian J, Baram TZ (2019) Programming of stress-sensitive neurons and circuits by early-life experiences. Front Behav Neurosci 13(30):1–9

Google Scholar 

Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM et al (2010) Early life programming and neurodevelopmental disorders. Biol Psychiatry 68(4):314–319

Article  PubMed  PubMed Central  Google Scholar 

Wood CE (2013) Development and programming of the hypothalamus-pituitary-adrenal axis. Clin Obstet Gynecol 56(3):610–621

Article  PubMed  Google Scholar 

Davis EP, Glynn LM, Waffarn F, Sandman CA (2011) Prenatal maternal stress programs infant stress regulation. J Child Psychol Psychiatry Allied Discip 52(2):119–129

Article  Google Scholar 

Cuffe JSM, Turton EL, Akison LK, Bielefeldt-Ohmann H, Moritz KM (2017) Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring. J Endocrinol 232(1):37–48

Article  CAS  PubMed  Google Scholar 

Briassoulis G, Damjanovic S, Xekouki P, Lefebvre H, Stratakis CA (2013) The glucocorticoid receptor and its expression in the anterior pituitary and the adrenal cortex : a source of variation in hypothalamic-pituitary-adrenal axis function. Implicat Pituit Adrenal Tumor 17(6):941–948

Google Scholar 

Díaz-Aguila Y, Cuevas-Romero E, Castelán F, Martínez-Gómez M, Rodríguez-Antolín J, Nicolás-Toledo L (2018) Chronic stress and high sucrose intake cause distinctive morphometric effects in the adrenal glands of post-weaned rats. Biotech Histochem 93(8):565–574

Article  PubMed  Google Scholar 

Bornstein SR, Berger I, Scriba L, Santambrogio A, Steenblock C (2019) Adrenal cortex–medulla interactions in adaptation to stress and disease. Curr Opin Endocr Metab Res 8:9–14

Article  Google Scholar 

Mitani F (2014) Functional zonation of the rat adrenal cortex: the development and maintenance. Proc Japan Acad Ser B Phys Biol Sci 90(5):163–183

Article  CAS  Google Scholar 

Kim A, Hammer GD (2007) Adrenocortical cells with stem/progenitor cell properties: recent advances advances. Mol Cell Endocrinol 23(1):1–7

Article  Google Scholar 

Okudaira N, Akimoto MH, Susa T, Akimoto M, Hisaki H, Iizuka M et al (2024) Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion. Aging Cell. https://doi.org/10.1111/acel.14206

Article  PubMed  PubMed Central  Google Scholar 

Vega-Vásquez T, Langgartner D, Wang JY, Reber SO, Picard M, Basualto-Alarcón C (2024) Mitochondrial morphology in the mouse adrenal cortex: Influence of chronic psychosocial stress. Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2023.106683

Article  PubMed  Google Scholar 

Moriceau S, Shionoya K, Jakubs K, Sullivan RM (2009) Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine. J Neurosci 29(50):15745–15755

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perry RE, Finegood ED, Braren SH, Dejoseph ML, Putrino DF, Wilson DA et al (2018) Developing a neurobehavioral animal model of poverty: drawing cross-species connections between environments of scarcity-adversity, parenting quality, and infant outcome. Dev Psychopathol 31(2):399–418

Article  PubMed  PubMed Central  Google Scholar 

Walker C-D, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ et al (2017) Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential: roundtable discussion at the 4th neurobiology of stress workshop (Newport Beach Apr). Stress 20(5):421–448

Article  PubMed  PubMed Central  Google Scholar 

Ghasemi A, Jeddi S, Kashfi K (2021) The laboratory rat: age and body weight matter. EXCLI J 20:1431–1445

PubMed  PubMed Central  Google Scholar 

Hodes GE, Bangasser D, Sotiropoulos I, Kokras N, Dalla C (2024) Sex differences in stress response: classical mechanisms and beyond. Curr Neuropharmacol 22(3):475–494

Article  CAS  PubMed  Google Scholar 

Chen W, Zhang Q, Su W, Zhang H, Yang Y, Qiao J et al (2014) Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats. Pharmacol Biochem Behav 117:25–33

Article  CAS  PubMed  Google Scholar 

Ivy AS, Brunson KL, Sandman C, Baram TZ (2008) Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress. Neuroscience 154(3):1132–1142

Article  CAS  PubMed  Google Scholar 

Kiernan J. Histological & Histochemical Methods 3Ed. Butterworths. 1999.

Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y (1999) Development of functional zonation in the rat adrenal cortex. Endocrinology 140(7):3342–3353

Article  CAS  PubMed  Google Scholar 

Diaz SL, Doly S, Narboux-Nme N, Fernández S, Mazot P, Banas SM et al (2012) 5-HT 2B receptors are required for serotonin-selective antidepressant actions. Mol Psychiatry 17(2):154–163

Article  CAS  PubMed  Google Scholar 

Munro CJ, Lasley B (1988) Non-radiometric methods for immunoassay of steroid hormones. Prog Clin Biol Res 285:289–329

CAS  PubMed  Google Scholar 

Pallarés ME, Monteleone MC, Pastor V, Grillo Balboa J, Alzamendi A, Brocco MA et al (2021) Early-life stress reprograms stress-coping abilities in male and female juvenile rats. Mol Neurobiol 58(11):5837–5856

Article  PubMed  Google Scholar 

Roth TL, Raineki C, Salstein L, Perry R, Sullivan-Wilson TA, Sloan A, Lalji B, Hammock E, Wilson DA, Levitt P, Okutani F, Kaba H, Sullivan RM (2013) Neurobiology of secure infant attachment and attachment despite adversity: a mouse model. Early Hum Dev 12(7):673–680

CAS  Google Scholar 

Perry R, Blaira C, Sullivan R (2017) Neurobiology of infant attachment: attachment despite adversity and parental programming of emotionality. Physiol Behav 176(10):139–148

Google Scholar 

Champagne FA, Francis DD, Mar A, Meaney MJ (2003) Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol Behav 79(3):359–371

Article  CAS