Teipel S, Gustafson D, Ossenkoppele R, Hansson O, Babiloni C, Wagner M, Riedel-Heller SG, Kilimann I, Tang Y (2022) Alzheimer disease: standard of diagnosis, treatment, care, and prevention. J Nucl Med 63:981–985

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen ZR, Huang JB, Yang SL, Hong FF (2022) Role of cholinergic signaling in Alzheimer’s disease. Molecules 27

Ma C, Hong F, Yang S (2022) Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions. Molecules 27

Yu H, Wu J (2021) Amyloid-β: A double agent in Alzheimer’s disease? Biomed Pharmacotherapy 139

Reiss AB, Arain HA, Stecker MM, Siegart NM, Kasselman LJ (2018) Amyloid toxicity in Alzheimer’s disease. Rev Neurosci 29:613–627

Article  CAS  PubMed  Google Scholar 

Rahman MS, Uddin MS, Rahman MA, Samsuzzaman M, Behl T, Hafeez A, Perveen A, Barreto GE, Ashraf GM (2021) Exploring the role of monoamine oxidase activity in aging and Alzheimer’s disease. Curr Pharm Design 27:4017–4029

Article  CAS  Google Scholar 

Zhang P, Xu S, Zhu Z, Xu J (2019) Multi-target design strategies for the improved treatment of Alzheimer’s disease. Eur J Med Chem 176:228–247

Article  CAS  PubMed  Google Scholar 

Piccialli I, Tedeschi V, Caputo L, D’Errico S, Ciccone R, De Feo V, Secondo A, Pannaccione A (2022) Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes. Frontiers in Pharmacology 13

Soodi M, Saeidnia S, Sharifzadeh M, Hajimehdipoor H, Dashti A, Sepand MR, Moradi S (2016) Satureja Bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer’s disease. Metab Brain Dis 31:395–404

Article  CAS  PubMed  Google Scholar 

Soodi M, Hajimehdipoor H, Ataei N, Akbari S (2016) Study of the protective effects of seven Iranian medicinal plant extracts against Beta-Amyloid induced cytotoxicity in PC12 cells. Pathobiology Res 19:45–58

Google Scholar 

Salleh WMNHW, Abed SA, Taher M, Kassim H, Tawang A (2021) The phytochemistry and biological diversity of ferulago genus (Apiaceae): A systematic review. J Pharm Pharmacol 73:1–21

Article  PubMed  Google Scholar 

Lorigooini Z, Koravand M, Haddadi H, Rafieian-Kopaei M, Shirmardi HA, Hosseini Z (2019) A review of botany, phytochemical and Pharmacological properties of Ferulago angulata. Toxin Reviews 38:13–20

Article  CAS  Google Scholar 

hazrati S, Ebadi MT, Mollaei S, Khurizadeh S (2019) Evaluation of volatile and phenolic compounds, and antioxidant activity of different parts of Ferulago angulata (schlecht.) Boiss. Industrial Crops and Products 140

Parsamehr R, Bohlouli S (2019) The effect of Ferulago angulata (Schelchet) Boiss on blood glucose levels and suppression of diabetes in rats. Acta Vet Brno 88:349–354

Article  Google Scholar 

Shafaroodi H, Roozbahani S, Asgarpanah J (2021) The essential oil from Ferulago angulata (Schltdl.) Boiss. Fruits exerting potent analgesic and anti-inflammatory effects. J Physiol Pharmacol 72:81–87

Google Scholar 

Mirzapour S, Rafieirad M, Rouhi L (2015) Hydroalcoholic extract of Ferulago angulata improves memory and pain in brain hypoperfusion ischemia in rats. Jundishapur J Nat Pharm Prod 10

Mahmoudi R, Rafieirad M, Goudarzi S (2018) Effect of hydroalcoholic extract of Ferulago angulata (Schlecht) Boiss on motor and memory disorders in animal model of Parkinson disease. Qom Univ Med Sci J 12:36–47

Article  Google Scholar 

Hritcu L, Bagci E, Aydin E, Mihasan M (2015) Antiamnesic and antioxidants effects of Ferulago angulata essential oil against Scopolamine-Induced memory impairment in laboratory rats. Neurochem Res 40:1799–1809

Article  CAS  PubMed  Google Scholar 

Akbari S, Soodi M, Hajimehdipoor H, Ataei N (2019) Protective effects of Sanguisorba minor and Ferulago angulata total extracts against beta-amyloid induced cytotoxicity and oxidative stress in cultured cerebellar granule neurons. J Herbmed Pharmacol 8:248–255

Article  CAS  Google Scholar 

Shamsi M, Soodi M, Hajimehdipoor H, Ghazanfari A (2021) Study of monoamine oxidase inhibitory effects of seven Iranian medicinal plant extracts. J Rep Pharm Sci 10:187–193

Article  CAS  Google Scholar 

Pękal A, Pyrzynska K (2014) Evaluation of aluminium complexation reaction for flavonoid content assay. Food Anal Methods 7:1776–1782

Article  Google Scholar 

Hooshmandi E, Motamedi F, Moosavi M, Katinger H, Zakeri Z, Zaringhalam J, Maghsoudi A, Ghasemi R, Maghsoudi N (2018) CEPO-Fc (An EPO Derivative) protects Hippocampus against Aβ-induced memory deterioration: A behavioral and molecular study in a rat model of Aβ toxicity. Neuroscience 388:405–417

Article  CAS  PubMed  Google Scholar 

Ellman GL, Courtney KD, Andres V Jr, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95

Article  CAS  PubMed  Google Scholar 

Ghahremanitamadon F, Shahidi S, Zargooshnia S, Nikkhah A, Ranjbar A, Soleimani Asl S (2014) Protective effects of Borago officinalis extract on amyloid β-peptide(25–35)-induced memory impairment in male rats: A behavioral study. BioMed Research International 2014

Shakerin Z, Esfandiari E, Ghanadian M, Razavi S, Alaei H, Dashti G (2020) Therapeutic effects of Cyperus rotundus rhizome extract on memory impairment, neurogenesis and mitochondria in beta-amyloid rat model of Alzheimer’s disease. Metab Brain Dis 35:451–461

Article  CAS  PubMed  Google Scholar 

Patricio-Martínez A, Sánchez-Zavaleta R, Angulo-Cruz I, Gutierrez-Praxedis L, Ramírez E, Martínez-García I, Limón ID (2019) The acute activation of the CB1 receptor in the Hippocampus decreases neurotoxicity and prevents Spatial memory impairment in rats lesioned with β-Amyloid 25–35. Neuroscience 416:239–254

Article  PubMed  Google Scholar 

Ghasemi R, Zarifkar A, Rastegar K, Maghsoudi N, Moosavi M (2014) Repeated intra-hippocampal injection of beta-amyloid 25–35 induces a reproducible impairment of learning and memory: considering caspase-3 and MAPKs activity. Eur J Pharmacol 726:33–40

Article  CAS  PubMed  Google Scholar 

Lu YZ, Zhang CQ, Yu BX, Zhang EH, Quan H, Yin X, Cai H, Yuan F, Li LQ, Xu YJ, Su YJ, Xing YJ, Liao ZH, Lan XZ (2021) The seed oil of Paeonia ludlowii ameliorates Aβ25-35-induced Alzheimer’s disease in rats. Food Sci Nutr 9:2402–2413

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alami-Rostami S, Rafieirad M (2018) The effect of hydro-alcoholic Ferulago angulata extract on locomotor activity and anxiety caused by hypoperfusion ischemia in adult male rats. J Herbmed Pharmacol 7

Sharifi F, Rafieirad M, Sazegar H (2015) Effects of Ferulago angulata extract against oxidative stress induced by 6-hydroxydopamine in rats. J Med Plants 14:34–44

Google Scholar 

Bagci E, Aydin E, Mihasan M, Maniu C, Hritcu L (2016) Anxiolytic and antidepressant-like effects of Ferulago angulata essential oil in the scopolamine rat model of Alzheimer’s disease. Flavour Fragr J 31:70–80

Article  CAS  Google Scholar 

Zhao Z, Ma L, Shi S, Hu H (2005) Study on the therapeutic effects of ginsenoside Rg-1 and Gastrodine on AD model rats induced by β-amyloid peptide (25–35). Acad J Xi’an Jiaotong Univ 17:181–184

CAS  Google Scholar 

García-Ayllón MS, Small DH, Avila J, Sáez-Valero J (2011) Revisiting the role of acetylcholinesterase in Alzheimer’s disease: Cross-Talk with P-tau and β-Amyloid. Front Mol Neurosci 4:22

Article  PubMed  PubMed Central  Google Scholar 

Moreira NCDS, Lima JEBDF, Marchiori MF, Carvalho I, Sakamoto-Hojo ET (2022) Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer’s disease and future perspectives. J Alzheimer’s Disease Rep 6:177–193

Article  Google Scholar 

Inestrosa NC, Dinamarca MC, Alvarez A (2008) Amyloid-cholinesterase interactions. Implications for Alzheimer’s disease. Febs J 275:625–632

Article  CAS  PubMed  Google Scholar 

Zhang XJ, Yang L, Zhao Q, Caen JP, He HY, Jin QH, Guo LH, Alemany M, Zhang LY, Shi YF (2002) Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ 9:790–800

Article  CAS  PubMed  Google Scholar 

Behl T, Kaur D, Sehgal A, Singh S, Sharma N, Zengin G, Andronie-Cioara FL, Toma MM, Bungau S, Bumbu AG (2021) Role of monoamine oxidase activity in Alzheimer’s disease: an insight into the therapeutic potential of inhibitors. Molecules 26

Mousseau DD, Baker GB (2012) Recent developments in the regulation of monoamine oxidase form and function: is the current model restricting our Understanding of the breadth of contribution of monoamine oxidase to brain [dys]function? Curr Top Med Chem 12:2163–2176

Article  CAS  PubMed  Google Scholar 

Manzoor S, Hoda N (2020) A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer’s disease agents: A review. Eur J Med Chem 206

Adolfsson R, Gottfries CG, Oreland L, Wiberg Å, Winblad B (1980) Increased activity of brain and platelet monoamine oxidase in dementia of alzheimer type. Life Sci 27:1029–1034

Article  CAS  PubMed  Google Scholar 

Syed AU, Liang C, Patel KK, Mondal R, Kamalia VM, Moran TR, Ahmed ST, Mukherjee J (2023) Comparison of monoamine Oxidase-A, Aβ plaques, Tau, and translocator protein levels in postmortem human Alzheimer’s disease brain. Int J Mol Sci 24:10808

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oboh G, Adedayo BC, Adetola MB, Oyeleye IS, Ogunsuyi OB (2022) Characterization and neuroprotective properties of alkaloid extract of Vernonia amygdalina delile in experimental models of Alzheimer’s disease. Drug Chem Toxicol 45:731–740