Novelli MM, Caramelli P (2010) The influence of neuropsychiatric and functional changes on quality of life in Alzheimer’s disease. Dement Neuropsychologia 4:47–53
Sultonova D, Akbarkhodjaeva Z (2018) Neuropsychiatric symptoms impact on quality life of patients with Parkinson’s disease. Parkinsonism Relat Disord 46:e49
Brandão PdMF et al (2022) Age, motor dysfunction and neuropsychiatric symptoms impact quality of life in multiple sclerosis. Revista Brasileira De Enfermagem 75:e20210207
Article PubMed PubMed Central Google Scholar
Allegri RF et al (2006) Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer’s disease. Neuropsychiatr Dis Treat 2(1):105–110
PubMed PubMed Central Google Scholar
Short AK, Baram TZ (2019) Early-life adversity and neurological disease: age-old questions and novel answers. Nat Reviews Neurol 15(11):657–669
Hong H, Kim BS, Im H-I (2016) Pathophysiological role of neuroinflammation in neurodegenerative diseases and psychiatric disorders. Int Neurourol J 20(Suppl 1):S2
Article PubMed PubMed Central Google Scholar
Cecerska-Heryć E et al (2022) Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review. Neurochem Int 153:105269
Zorkina Y et al (2020) Nano carrier drug delivery systems for the treatment of neuropsychiatric disorders: advantages and limitations. Molecules 25(22):5294
Article CAS PubMed PubMed Central Google Scholar
Mitra NK, Wadingasafi NANB, Chellian J (2022) Locomotor and histological changes in a cuprizone-induced animal model of multiple sclerosis: comparison between alpha-tocopherol and fingolimod. Res Pharm Sci 17(2):134
Article PubMed PubMed Central Google Scholar
Wang CC, Kuo JR, Wang SJ (2021) Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein βγ subunit-dependent pathway in rat cerebrocortical nerve terminals. Neuropharmacology 185:108451
Article CAS PubMed Google Scholar
Rajan S et al (2024) Fingolimod exerts neuroprotection by regulating S1PR1 mediated BNIP3-PINK1-Parkin dependent mitophagy in rotenone induced mouse model of Parkinson’s disease. Neurosci Lett 820:137596
Article CAS PubMed Google Scholar
Sood A et al (2023) Fingolimod alleviates cognitive deficit in type 2 diabetes by promoting Microglial M2 polarization via the pSTAT3-jmjd3 Axis. Mol Neurobiol 60(2):901–922
Article CAS PubMed Google Scholar
Makled MN, Serrya MS, El-Sheakh AR (2022) Fingolimod ameliorates acetic acid‐induced ulcerative colitis: an insight into its modulatory impact on pro/anti‐inflammatory cytokines and AKT/mTOR signalling, vol 130. Basic & Clinical Pharmacology & Toxicology, pp 569–580. 5
Brunkhorst R, Vutukuri R, Pfeilschifter W (2014) Fingolimod for the treatment of neurological diseases—state of play and future perspectives. Front Cell Neurosci 8:283
Article PubMed PubMed Central Google Scholar
Yoshii F et al (2017) Neurological safety of fingolimod: an updated review. Clin Exp Neuroimmunol 8:233–243
Article PubMed PubMed Central Google Scholar
Bascuñana P et al (2020) Fingolimod as a treatment in neurologic disorders beyond multiple sclerosis. Drugs R D 20:197–207
Article PubMed PubMed Central Google Scholar
Maceyka M et al (2012) Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol 22(1):50–60
Article CAS PubMed Google Scholar
Weth-Malsch D et al (2016) Ablation of sphingosine 1-phosphate receptor subtype 3 impairs hippocampal neuron excitability in vitro and spatial working memory in vivo. Front Cell Neurosci 10:258
Article PubMed PubMed Central Google Scholar
Squillace S et al (2022) Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment. J Clin Investig, 132(17)
Jang S et al (2011) Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety. Neurochem Res 36:258–267
Article CAS PubMed Google Scholar
Pournajaf S et al (2022) Molecular pharmacology and novel potential therapeutic applications of fingolimod. Front Pharmacol 13:807639
Article CAS PubMed PubMed Central Google Scholar
Foster CA et al (2007) Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J Pharmacol Exp Ther 323(2):469–475
Article CAS PubMed Google Scholar
Mandala S et al (2002) Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296(5566):346–349
Article CAS PubMed Google Scholar
Brinkmann V et al (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 277(24):21453–21457
Article CAS PubMed Google Scholar
Oo ML et al (2007) Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem 282(12):9082–9089
Article CAS PubMed Google Scholar
Graler M Goetzl E](2004) The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors FASEB/18: p. 551–553
Matloubian M et al (2004) Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427(6972):355–360
Article CAS PubMed Google Scholar
Groves A, Kihara Y, Chun J (2013) Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci 328(1–2):9–18
Article CAS PubMed PubMed Central Google Scholar
Fagan SG, Bechet S, Dev KK (2022) Fingolimod Rescues memory and improves pathological hallmarks in the 3xTg-AD model of Alzheimer’s disease Molecular neurobiology, : pp. 1–14
Zhang J et al (2020) Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging. Neural Regeneration Res 15(7):1308
Zhao P et al (2017) Neuroprotective effects of fingolimod in mouse models of Parkinson’s disease. FASEB J 31(1):172–179
Article CAS PubMed Google Scholar
Shang K et al (2020) Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization. Brain Res 1726:146509
Article CAS PubMed Google Scholar
Davy M et al (2023) Evaluation of Temozolomide and Fingolimod treatments in Glioblastoma Preclinical models. Cancers 15(18):4478
Article CAS PubMed PubMed Central Google Scholar
Malone K et al (2021) The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia. J Neuroinflamm 18(1):1–15
Marx W et al (2023) Major Depressive Disorder 9(1):44
Organization WH Depression-Fact sheets [Internet]. 2020
Jeon SW, Kim Y-K (2018) The role of neuroinflammation and neurovascular dysfunction in major depressive disorder. J Inflamm Res, : p. 179–192
Barbosa ML et al (2020) Oxidative stress, antioxidant defense and depressive disorders: a systematic review of biochemical and molecular markers. Neurol Psychiatry Brain Res 36:65–72
Mutz J et al (2018) Efficacy and acceptability of non-invasive brain stimulation for the treatment of adult unipolar and bipolar depression: a systematic review and meta-analysis of randomised sham-controlled trials. Neurosci Biobehavioral Reviews 92:291–303
Comments (0)