Carabotti M, Scirocco A, Maselli MA, Severi C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 28:203–209
PubMed PubMed Central Google Scholar
Dogra N, Mani RJ, Katare DP (2022) The gut-brain Axis: two Ways Signaling in Parkinson’s Disease. Cell Mol Neurobiol 42:315–332
Article CAS PubMed Google Scholar
Castillo-Álvarez F, Marzo-Sola ME (2022) Role of the gut microbiota in the development of various neurological diseases. Neurologia (Engl Ed) 37:492–498
Kulisevsky J (2022) Pharmacological management of Parkinson’s disease motor symptoms: update and recommendations from an expert. Rev Neurol 75:S1–S10
CAS PubMed PubMed Central Google Scholar
Espay AJ, Morgante F, Merola A, Fasano A, Marsili L, Fox SH, Bezard E, Picconi B, Calabresi P, Lang AE (2018) Levodopa-induced dyskinesia in Parkinson disease: current and evolving concepts. Ann Neurol 84:797–811
Di Luca DG, Reyes NGD, Fox SH (2022) Newly approved and Investigational Drugs for Motor Symptom Control in Parkinson’s Disease. Drugs 82:1027–1053
Article PubMed PubMed Central Google Scholar
Boelens Keun JT, Arnoldussen IA, Vriend C, van de Rest O (2021) Dietary approaches to Improve Efficacy and Control Side Effects of Levodopa Therapy in Parkinson’s Disease: a systematic review. Adv Nutr 12:2265–2287
Article CAS PubMed PubMed Central Google Scholar
Baizabal-Carvallo JF, Alonso-Juarez M, Fekete R (2021) Intestinal decontamination therapy for Dyskinesia and Motor fluctuations in Parkinson’s Disease. Front Neurol 12:729961
Article PubMed PubMed Central Google Scholar
Palacios N, Hannoun A, Flahive J, Ward D, Goostrey K, Deb A, Smith KM (2021) Effect of levodopa initiation on the gut microbiota in Parkinson’s Disease. Front Neurol 12:574529
Article PubMed PubMed Central Google Scholar
Perez Visñuk D, Savoy de Giori G, LeBlanc JG, de Moreno de LeBlanc A (2020) Neuroprotective effects associated with immune modulation by selected lactic acid bacteria in a Parkinson’s disease model. Nutrition 79–80:110995
Carta AR, Carboni E, Spiga S (2013) The MPTP/probenecid model of progressive Parkinson’s disease. Methods Mol Biol 964:295–308
Article CAS PubMed Google Scholar
Plantone D, Pardini M, Rinaldi G (2021) Riboflavin in Neurological diseases: a narrative review. Clin Drug Investig 41:513–527
Article CAS PubMed Google Scholar
Perez Visñuk D, Teran MDM, Savoy de Giori G, LeBlanc JG (2022) de Moreno de LeBlanc A Neuroprotective Effect of Riboflavin Producing Lactic Acid Bacteria in Parkinsonian Models. Neurochem Res 47:1269–1279
Quan Y, Xu J, Xu Q, Guo Z, Ou R, Shang H, Wei Q (2023) Association between the risk and severity of Parkinson’s disease and plasma homocysteine, vitamin B12 and folate levels: a systematic review and meta-analysis. Front Aging Neurosci 15:1254824
Article CAS PubMed PubMed Central Google Scholar
Belcastro V, Pierguidi L, Castrioto A, Menichetti C, Gorgone G, Ientile R, Pisani F, Rossi A, Calabresi P, Tambasco N (2010) Hyperhomocysteinemia recurrence in levodopa-treated Parkinson’s disease patients. Eur J Neurol 17:661–665
Article CAS PubMed Google Scholar
Levit R, Savoy de Giori G, de Moreno de LeBlanc A, LeBlanc JG (2019) Beneficial effect of a mixture of vitamin-producing and immune-modulating lactic acid bacteria as adjuvant for therapy in a recurrent mouse colitis model. Appl Microbiol Biotechnol
Juarez del Valle M, Laiño J, Savoy de Giori G, LeBlanc JGI (2014) Use of lactic acid Bacteria as a Biotechnological Strategy to increase Riboflavin levels in Soymilk. Food Res Int 62:1015–1019
Laiño JE, Leblanc JG, Savoy de Giori G (2012) Production of natural folates by lactic acid bacteria starter cultures isolated from artisanal Argentinean yogurts. Can J Microbiol 58:581–588
Szczesna K, de la Caridad O, Petazzi P, Soler M, Roa L, Saez MA, Fourcade S, Pujol A, Artuch-Iriberri R, Molero-Luis M, Vidal A, Huertas D, Esteller M (2014) Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor. Neuropsychopharmacology 39:2846–2856
Article CAS PubMed PubMed Central Google Scholar
Paxinos G, Franklin K (2008) The mouse brain in stereotaxic coordinates. Academic
. Nutrients
Levit R, Savoy de Giori G, de Moreno de LeBlanc A, LeBlanc JG (2018) Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice. Nutrition 54:165–172
Article CAS PubMed Google Scholar
Amazzal L, Lapôtre A, Quignon F, Bagrel D (2007) Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells. Neurosci Lett 418:159–164
Article CAS PubMed Google Scholar
Olfat N, Ashoori M, Saedisomeolia A (2022) Riboflavin is an antioxidant: a review update. Br J Nutr 128:1887–1895
Article CAS PubMed Google Scholar
Wang LW, Lin HJ, Chao CM, Lin MT, Wang LY, Chein LH, Chang CP, Chio CC (2022) The interrelationships between neuronal viability, synaptic integrity, microglial responses, and amyloid-beta formation in an in vitro neurotrauma model. Sci Rep 12:22028
Article CAS PubMed PubMed Central Google Scholar
del Carmen S, de Moreno de LeBlanc A, Martin R, Chain F, Langella P, Bermudez-Humaran LG, LeBlanc JG (2014) Genetically engineered immunomodulatory Streptococcus thermophilus strains producing antioxidant enzymes exhibit enhanced anti-inflammatory activities. Appl Environ Microbiol 80:869–877
Article PubMed PubMed Central Google Scholar
Teixeira FG, Vilaça-Faria H, Domingues AV, Campos J, Salgado AJ (2020) Preclinical Comparison of Stem Cells Secretome and Levodopa Application in a 6-Hydroxydopamine Rat Model of Parkinson’s Disease. Cells 9
Levit R, Savoy de Giori G, de Moreno de LeBlanc A, LeBlanc JG (2021) Evaluation of vitamin-producing and immunomodulatory lactic acid bacteria as a potential co-adjuvant for cancer therapy in a mouse model. J Appl Microbiol 130:2063–2074
Article CAS PubMed Google Scholar
Pajares M, Manda AIR, Boscá G, Cuadrado L (2020) A Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications. Cells 9
García-Domínguez I, Veselá K, García-Revilla J, Carrillo-Jiménez A, Roca-Ceballos MA, Santiago M, de Pablos RM, Venero JL (2018) Peripheral inflammation enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease. Front Cell Neurosci 12:398
Article PubMed PubMed Central Google Scholar
Machado V, Zöller T, Attaai A, Spittau B (2016) Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson’s Disease-Lessons from Transgenic Mice. Int J Mol Sci 17
Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, Estes JD, Dodiya HB, Keshavarzian A (2011) Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease. PLoS ONE 6:e28032
Article CAS PubMed PubMed Central Google Scholar
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK (2016) Gut microbiota regulate Motor deficits and neuroinflammation in a model of Parkinson’s Disease. Cell 167:1469–1480 e1412
Article CAS PubMed PubMed Central Google Scholar
Braak H, Rüb U, Gai WP, Del Tredici K (2003) Idiopathic Parkinson’s disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm (Vienna) 110:517–536
Article CAS PubMed Google Scholar
Lin CH, Chen CC, Chiang HL, Liou JM, Chang CM, Lu TP, Chuang EY, Tai YC, Cheng C, Lin HY, Wu MS (2019) Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease. J Neuroinflammation 16:129
Article PubMed PubMed Central Google Scholar
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