NMN Synbiotics: A Multifaceted Therapeutic Approach for Alzheimer’s Disease

Zhang H, Zheng Y (2019) β amyloid hypothesis in Alzheimer’s disease: pathogenesis, prevention, and management. Acta Academiae Medicinae Sinicae 41:702–708. https://doi.org/10.3881/j.issn.1000-503x.10875

Article  PubMed  Google Scholar 

Westfall S, Lomis N, Prakash S (2019) A novel synbiotic delays Alzheimer’s disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster. PLoS ONE 14:e0214985. https://doi.org/10.1371/journal.pone.0214985

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schibler U (2020) Senescence of timing reverted: NAD + rejuvenates the circadian clock. Mol Cell 78:805–807. https://doi.org/10.1016/j.molcel.2020.05.010

Article  CAS  PubMed  Google Scholar 

Wang X, Hu X, Yang Y, Takata T, Sakurai T (2016) Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res 1643:1–9. https://doi.org/10.1016/j.brainres.2016.04.060

Article  CAS  PubMed  Google Scholar 

Yao Z, Yang W, Gao Z, Jia P (2017) Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease. Neurosci Lett 647:133–140. https://doi.org/10.1016/j.neulet.2017.03.027

Article  CAS  PubMed  Google Scholar 

Zhao X, Kong M, Wang Y, Mao Y, Xu H, He W, He Y, Gu J (2023) Nicotinamide mononucleotide improves the alzheimer’s disease by regulating intestinal microbiota. Biochem Biophys Res Commun 670:27–35. https://doi.org/10.1016/j.bbrc.2023.05.075

Article  CAS  PubMed  Google Scholar 

Zhao Y, Yang G, Zhao Z, Wang C, Duan C, Gao L, Li S (2020) Antidepressant-like effects of Lactobacillus plantarum DP189 in a corticosterone-induced rat model of chronic stress. Behav Brain Res 395:112853. https://doi.org/10.1016/j.bbr.2020.112853

Article  CAS  PubMed  Google Scholar 

Wang L, Zhao Z, Zhao L, Zhao Y, Yang G, Wang C, Gao L, Niu C, Li S (2022) Lactobacillus plantarum DP189 reduces α-SYN aggravation in MPTP-induced parkinson’s disease mice via regulating oxidative damage, inflammation, and gut microbiota disorder. J Agric Food Chem 70:1163–1173. https://doi.org/10.1021/acs.jafc.1c07711

Article  CAS  PubMed  Google Scholar 

Panesar PS, Kumari S (2011) Lactulose: production, purification and potential applications. Biotechnol Adv 29:940–948. https://doi.org/10.1016/j.biotechadv.2011.08.008

Article  CAS  PubMed  Google Scholar 

Lee YS, Lai DM, Huang HJ, Lee-Chen GJ, Chang CH, Hsieh-Li HM, Lee GC (2021) Prebiotic lactulose ameliorates the cognitive deficit in Alzheimer’s disease mouse model through macroautophagy and chaperone-mediated autophagy pathways. J Agric Food Chem 69:2422–2437. https://doi.org/10.1021/acs.jafc.0c07327

Article  CAS  PubMed  Google Scholar 

Markowiak P, Śliżewska K (2017) Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 9:1021. https://doi.org/10.3390/nu9091021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daulatzai MA (2014) Chronic functional bowel syndrome enhances gut-brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and vulnerability to Dementia. Neurochem Res 39:624–644. https://doi.org/10.1007/s11064-014-1266-6

Article  CAS  PubMed  Google Scholar 

Li Y, Wu M, Kong M, Sui S, Wang Q, He Y, Gu J (2023) Impact of Donepezil supplementation on Alzheimer’s Disease-like Pathology and Gut Microbiome in APP/PS1 mice. Microorganisms 11:2306. https://doi.org/10.3390/microorganisms11092306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai R, Guo J, Ye X-Y, Xie Y, Xie T (2022) Oxidative stress: the core pathogenesis and mechanism of Alzheimer’s disease. Ageing Res Rev 77:101619. https://doi.org/10.1016/j.arr.2022.101619

Article  CAS  PubMed  Google Scholar 

Wang QJ, Shen YE, Wang X, Fu S, Zhang X, Zhang YN, Wang RT (2020) Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice. Aging 12:628. https://doi.org/10.18632/aging.102645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao D, Liu Z, Liu F, Chen L, Wang W, Ma J, Xu C, Jiang Z, Hou J (2021) Study of the immunoregulatory effect of Lactobacillus rhamnosus 1.0320 in immunosuppressed mice. J Funct Foods 79:104423. https://doi.org/10.1016/j.jff.2021.104423

Article  CAS  Google Scholar 

Algieri F, Rodriguez-Nogales A, Garrido-Mesa N, Vezza T, Garrido-Mesa J, Utrilla MP, Montilla A, Cardelle-Cobas A, Olano A, Corzo N (2014) Intestinal anti-inflammatory effects of oligosaccharides derived from lactulose in the trinitrobenzenesulfonic acid model of rat colitis. J Agric Food Chem 62:4285–4297. https://doi.org/10.1021/jf500678p

Article  CAS  PubMed  Google Scholar 

Wang Y, Wang D, Lv H, Dong Q, Li J, Geng W, Wang J, Liu F, Jia L, Wang Y (2022) Modulation of the gut microbiota and glycometabolism by a probiotic to alleviate amyloid accumulation and cognitive impairments in AD rats. Mol Nutr Food Res 66:2200265. https://doi.org/10.1002/mnfr.202200265

Article  CAS  Google Scholar 

Leng D, Fang X, Li X (2023) Protective effect of lactulose regulating NOX4/NLRP3 pathway on rats with rheumatoid arthritis. Jounal Guangxi Medial Unvesity 40:262–267. https://doi.org/10.16190/j.cnki.45-1211/r.2023.02.012

Article  Google Scholar 

Cheignon Cm, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F (2018) Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox Biol 14:450–464. https://doi.org/10.1016/j.redox.2017.10.014

Article  CAS  Google Scholar 

Sharma A, Martins I (2023) The role of Microbiota in the pathogenesis of Alzheimer’s disease. Acta Sci Nutritional Health 7:108–118. https://doi.org/10.31080/ASNH.2023.07.1272

Article  Google Scholar 

Martins I (2018) Bacterial lipopolysaccharides and Neuron Toxicity in neurodegenerative diseases. Neurol Neurosurg 2:1–3. https://doi.org/10.33425/2641-4333.1001

Article  Google Scholar 

Lee HJ, Park JH, Hoe HS (2022) Idebenone regulates Aβ and LPS-Induced neurogliosis and cognitive function through inhibition of NLRP3 Inflammasome/IL-1β Axis Activation. Front Immunol 13:749336. https://doi.org/10.3389/fimmu.2022.749336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee HJ, Hwang YH, Kim DH (2018) Lactobacillus plantarum C29-Fermented soybean (DW2009) alleviates memory impairment in 5XFAD Transgenic mice by regulating Microglia activation and gut microbiota composition. Mol Nutr Food Res 62:e1800359. https://doi.org/10.1002/mnfr.201800359

Article  CAS  PubMed  Google Scholar 

Tian Y, Zhu CL, Li P, Li HR, Liu Q, Deng XM, Wang JF (2023) Nicotinamide Mononucleotide attenuates LPS-Induced Acute Lung Injury with Anti-Inflammatory, Anti-oxidative and Anti-apoptotic effects. J Surg Res 283:9–18. https://doi.org/10.1016/j.jss.2022.09.030

Article  CAS  PubMed  Google Scholar 

SUN Y (2008) Effect of Lactulose on Plasm Lipoplysaccharide Endotoxin(LPS), Tumor Necrosis Factor-a(TNF) and ALT in cirrhotic rats. Guide China Med 17:4–5. https://doi.org/10.15912/j.cnki.gocm.2008.17.161

Article  Google Scholar 

Zhang J, Zhao X, Xu H, Liu X, He Y, Tan X, Gu J (2024) NMN synbiotics intervention modulates gut microbiota and metabolism in APP/PS1 Alzheimer’s disease mouse models. Biochem Biophys Res Commun 726:150274. https://doi.org/10.1016/j.bbrc.2024.150274

Article  CAS  PubMed  Google Scholar 

Dong H, Zhao B, Chen J, Liu Z, Li X, Li L, Wen H (2022) Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome. Proc Natl Acad Sci 119:e2123247119. https://doi.org/10.1073/pnas.2123247119

Article  CAS  PubMed 

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