Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability

Kanner L. Autistic disturbances of affective contact. Nerv Child. 1943;2:217–50.

Google Scholar 

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013. p. 947.

Book  Google Scholar 

Maenner MJ, Warren Z, Williams AR, Amoakohene E, Bakian AV, Bilder DA, et al. Prevalence and characteristics of Autism Spectrum Disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020. MMWR Surveill Summ. 2023;72(2):1–14.

Article  PubMed  PubMed Central  Google Scholar 

Genovese A, Butler MG. Clinical Assessment, Genetics, and treatment approaches in Autism Spectrum disorder (ASD). Int J Mol Sci. 2020;21(13).

He X, Sanders SJ, Liu L, De Rubeis S, Lim ET, Sutcliffe JS, et al. Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes. PLoS Genet. 2013;9(8):e1003671.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tordjman S, Cohen D, Anderson GM, Botbol M, Canitano R, Coulon N, et al. Repint of reframing autism as a behavioral syndrome and not a specific mental disorder: implications of genetic and phenotypic heterogeneity. Neurosci Biobehav Rev. 2018;89:132–50.

Article  CAS  PubMed  Google Scholar 

Stachnik JM, Nunn-Thompson C. Use of atypical antipsychotics in the treatment of autistic disorder. Ann Pharmacother. 2007;41(4):626–34.

Article  CAS  PubMed  Google Scholar 

McPheeters ML, Warren Z, Sathe N, Bruzek JL, Krishnaswami S, Jerome RN, et al. A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics. 2011;127(5):e1312–21.

Article  PubMed  Google Scholar 

Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, et al. Is Oxytocin Nature’s Medicine? Pharmacol Rev. 2020;72(4):829–61.

PubMed  Google Scholar 

Parker KJ, Oztan O, Libove RA, Sumiyoshi RD, Jackson LP, Karhson DS, et al. Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism. Proc Natl Acad Sci U S A. 2017;114(30):8119–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grinevich V, Desarmenien MG, Chini B, Tauber M, Muscatelli F. Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders. Front Neuroanat. 2014;8:164.

PubMed  Google Scholar 

Borie AM, Theofanopoulou C, Andari E. The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder. Handb Clin Neurol. 2021;182:121–40.

Article  PubMed  PubMed Central  Google Scholar 

Froemke RC, Carcea I. Oxytocin and brain plasticity. Principles of gender-specific medicine. 3rd ed. Academic; 2017. pp. 161–82.

Amaral DG, Schumann CM, Nordahl CW. Neuroanatomy of autism. Trends Neurosci. 2008;31(3):137–45.

Article  CAS  PubMed  Google Scholar 

Lee HJ, Macbeth AH, Pagani JH, Young WS 3. Oxytocin: the great facilitator of life. Prog Neurobiol. 2009;88(2):127–51.

Penagarikano O, Lazaro MT, Lu XH, Gordon A, Dong H, Lam HA, et al. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med. 2015;7(271):271ra8.

Article  PubMed  PubMed Central  Google Scholar 

Harony-Nicolas H, Kay M, du Hoffmann J, Klein ME, Bozdagi-Gunal O, Riad M et al. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. Elife. 2017;6.

Sikich L, Kolevzon A, King BH, McDougle CJ, Sanders KB, Kim SJ, et al. Intranasal oxytocin in children and adolescents with Autism Spectrum Disorder. N Engl J Med. 2021;385(16):1462–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, et al. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology. 2001;57(2):245–54.

Article  CAS  PubMed  Google Scholar 

Hazlett HC, Poe M, Gerig G, Smith RG, Provenzale J, Ross A, et al. Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Arch Gen Psychiatry. 2005;62(12):1366–76.

Article  PubMed  Google Scholar 

Courchesne E, Carper R, Akshoomoff N. Evidence of brain overgrowth in the first year of life in autism. JAMA. 2003;290(3):337–44.

Article  PubMed  Google Scholar 

Courchesne E, Campbell K, Solso S. Brain growth across the life span in autism: age-specific changes in anatomical pathology. Brain Res. 2011;1380:138–45.

Article  CAS  PubMed  Google Scholar 

Schmitz N, Daly E, Murphy D. Frontal anatomy and reaction time in Autism. Neurosci Lett. 2007;412(1):12–7.

Article  CAS  PubMed  Google Scholar 

Hughes JR. Autism: the first firm finding = underconnectivity? Epilepsy Behav. 2007;11(1):20–4.

Article  PubMed  Google Scholar 

Boger-Megiddo I, Shaw DW, Friedman SD, Sparks BF, Artru AA, Giedd JN, et al. Corpus callosum morphometrics in young children with autism spectrum disorder. J Autism Dev Disord. 2006;36(6):733–9.

Article  PubMed  Google Scholar 

Wolff JJ, Gu H, Gerig G, Elison JT, Styner M, Gouttard S, et al. Differences in white matter fiber tract development present from 6 to 24 months in infants with autism. Am J Psychiatry. 2012;169(6):589–600.

Article  PubMed  PubMed Central  Google Scholar 

Lee E, Lee J, Kim E. Excitation/Inhibition imbalance in animal models of Autism Spectrum disorders. Biol Psychiatry. 2017;81(10):838–47.

Article  PubMed  Google Scholar 

Pagani M, Barsotti N, Bertero A, Trakoshis S, Ulysse L, Locarno A, et al. mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity. Nat Commun. 2021;12(1):6084.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Supekar K, Uddin LQ, Khouzam A, Phillips J, Gaillard WD, Kenworthy LE, et al. Brain hyperconnectivity in children with autism and its links to social deficits. Cell Rep. 2013;5(3):738–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yui K, Kawasaki Y, Yamada H, Ogawa S. Oxidative stress and nitric oxide in Autism Spectrum Disorder and other Neuropsychiatric disorders. CNS Neurol Disord Drug Targets. 2016;15(5):587–96.

Article  CAS  PubMed  Google Scholar 

Dimond D, Schuetze M, Smith RE, Dhollander T, Cho I, Vinette S, et al. Reduced White Matter Fiber Density in Autism Spectrum Disorder. Cereb Cortex. 2019;29(4):1778–88.

Article  PubMed  PubMed Central  Google Scholar 

Kim YS, Choi J, Yoon BE. Neuron-glia interactions in Neurodevelopmental disorders. Cells. 2020;9(10).

Noriuchi M, Kikuchi Y, Yoshiura T, Kira R, Shigeto H, Hara T, et al. Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder. Brain Res. 2010;1362:141–9.

Article  CAS  PubMed  Google Scholar 

Zikopoulos B, Garcia-Cabezas MA, Barbas H. Parallel trends in cortical gray and white matter architecture and connections in primates allow fine study of pathways in humans and reveal network disruptions in autism. PLoS Biol. 2018;16(2):e2004559.

Article  PubMed  PubMed Central  Google Scholar 

Kazdoba TM, Leach PT, Crawley JN. Behavioral phenotypes of genetic mouse models of autism. Genes Brain Behav. 2016;15(1):7–26.

Article  CAS  PubMed  Google Scholar 

Moy SS, Nadler JJ, Young NB, Nonneman RJ, Segall SK, Andrade GM, et al. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res. 2008;191(1):118–29.

Article  PubMed  PubMed Central 

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