Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP et al (2019) ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): the task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 41(4):543–603

Google Scholar 

Wendelboe AM, Raskob GE (2016) Global burden of thrombosis. Circ Res 118:1340–1347

Article  CAS  PubMed  Google Scholar 

Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ et al (2014) Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol 34:2363–2371

Article  CAS  PubMed  Google Scholar 

Keller K, Hobohm L, Ebner M, Kresoja KP, Münzel T, Konstantinides SV et al (2020) Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany. Eur Heart J 41:522–529

Article  PubMed  Google Scholar 

Jimenez D, Lobo JL, Fernandez-Golfin C, Portillo AK, Nieto R, Lankeit M et al (2016) Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. Thromb Haemost 115:827–834

Article  PubMed  Google Scholar 

Mirambeaux R, León F, Bikdeli B, Morillo R, Barrios D, Mercedes E et al (2019) Intermediate-high risk pulmonary embolism. TH Open Compan J Thromb Haemost 3:e356–e363

Google Scholar 

Frat JP, Ciurzyński M (2024) Intermediate-risk acute pulmonary embolism: simply oxygen? Chest 165:484–485

Article  PubMed  Google Scholar 

Fields JM, Davis J, Girson L, Au A, Potts J, Morgan CJ et al (2017) Transthoracic echocardiography for diagnosing pulmonary embolism: a systematic review and meta-analysis. J Am Soc Echocardiogr 30:714-723.e4

Article  PubMed  Google Scholar 

Parker CW, Kolimas AM, Kotini-Shah P (2022) Velocity-time integral: a bedside echocardiography technique finding a place in the emergency department. J Emerg Med 63(3):382–388

Article  PubMed  Google Scholar 

Nguyen PC, Stevens H, Peter K, McFadyen JD (2021) Submassive pulmonary embolism: current perspectives and future directions. J Clin Med 10:3383

Article  PubMed  PubMed Central  Google Scholar 

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan—a web and mobile app for systematic reviews. Syst Rev 5:210

Article  PubMed  PubMed Central  Google Scholar 

Whiting PF, Rutjes AWS, Westwood ME, Mallett S, Deeks JJ, Reitsma JB et al (2011) QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155:529–536

Article  PubMed  Google Scholar 

Babes EE, Stoicescu M, Bungau SG, Uivarosan D, Tit DM, Toma MM et al (2022) Left ventricle outflow tract velocity-time index and right ventricle to left ventricle ratio as predictors for in hospital outcome in intermediate-risk pulmonary embolism. Diagnostics 12:1226

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brailovsky Y, Lakhter V, Weinberg I, Porcaro K, Haines J, Morris S et al (2019) Right ventricular outflow doppler predicts low cardiac index in intermediate risk pulmonary embolism. Clin Appl Thromb 25:1076029619886062

Article  Google Scholar 

Falsetti L, Marra AM, Zaccone V, Sampaolesi M, Riccomi F, Giovenali L et al (2022) Echocardiographic predictors of mortality in intermediate-risk pulmonary embolism. Intern Emerg Med 17:1287–1299

Article  PubMed  Google Scholar 

Porcaro K, Haines J, Morris S, Doukas D, Mancl E, Masic D et al (2019) Predictors of low cardiac index in submassive pulmonary embolism. J Am Coll Cardiol 73:2111

Article  Google Scholar 

Prosperi-Porta G, Solverson K, Fine N, Humphreys CJ, Ferland A, Weatherald J (2020) Echocardiography-derived stroke volume index is associated with adverse in-hospital outcomes in intermediate-risk acute pulmonary embolism. Chest 158:1132–1142

Article  PubMed  Google Scholar 

Weekes AJ, Hambright P, Trautmann A, Ali S, Pikus A, Wellinsky N et al (2024) Low stroke volume predicts deterioration in intermediate-risk pulmonary embolism: prospective study. West J Emerg Med. 25(4):533

PubMed  PubMed Central  Google Scholar 

Yuriditsky E, Mitchell OJL, Sista AK, Xia Y, Sibley RA, Zhong J et al (2020) Right ventricular stroke distance predicts death and clinical deterioration in patients with pulmonary embolism. Thromb Res 195:29–34

Article  CAS  PubMed  Google Scholar 

Yuriditsky E, Mitchell OJ, Sibley RA, Xia Y, Sista AK, Zhong J et al (2020) Low left ventricular outflow tract velocity time integral is associated with poor outcomes in acute pulmonary embolism. Vasc Med 25:133–140

Article  PubMed  Google Scholar 

Zhang RS, Yuriditsky E, Nayar AC, Elbaum L, Greco AA, Rhee AJ et al (2024) Low left ventricular outflow tract velocity time integral predicts normotensive shock in patients with acute pulmonary embolism. Am Heart J 272:106–108

Article  PubMed  Google Scholar 

Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP et al (2019) ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): the task force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J. 41(4):543–603

Google Scholar 

Nguyen PC, Stevens H, Peter K, McFadyen JD (2021) Submassive pulmonary embolism: current perspectives and future directions. J Clin Med 10:3383

Article  PubMed  PubMed Central  Google Scholar 

Deeks JJ, Macaskill P, Irwig L (2005) The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol 58:882–893

Article  PubMed  Google Scholar 

Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldman JH, Schiller NB, Lim DC, Redberg RF, Foster E (2001) Usefulness of stroke distance by echocardiography as a surrogate marker of cardiac output that is independent of gender and size in a normal population. Am J Cardiol 87:499–502

Article  CAS  PubMed  Google Scholar 

Mowat DHR, Haites NE, Rawles JM (1983) Aortic blood velocity measurement in healthy adults using a simple ultrasound technique. Cardiovasc Res 17:75–80

Article  CAS  PubMed  Google Scholar 

Machanahalli Balakrishna A, Reddi V, Belford PM, Alvarez M, Jaber WA, Zhao DX et al (2022) Intermediate-risk pulmonary embolism: a review of contemporary diagnosis, risk stratification and management. Medicina (Kaunas) 58:1186

Article  PubMed  Google Scholar 

Chen X, Shao X, Zhang Y, Zhang Z, Tao X, Zhai Z et al (2020) Assessment of the Bova score for risk stratification of acute normotensive pulmonary embolism: a systematic review and meta-analysis. Thromb Res 193:99–106

Article  CAS  PubMed  Google Scholar 

Talan J, Mangalick K, Pradhan D, Sauthoff H (2024) Accuracy of echocardiographic cardiac output assessment by critical care fellows. ATS Scholar 5(4):547–558

Article  PubMed  PubMed Central  Google Scholar 

Dinh VA, Ko HS, Rao R, Bansal RC, Smith DD, Kim TE et al (2012) Measuring cardiac index with a focused cardiac ultrasound examination in the ED. Am J Emerg Med 30:1845–1851

Article  PubMed  Google Scholar 

Becattini C, Cohen AT, Agnelli G, Howard L, Castejón B, Trujillo-Santos J et al (2016) Risk stratification of patients with acute symptomatic pulmonary embolism based on presence or absence of lower extremity DVT: systematic review and meta-analysis. Chest 149:192–200

Article  PubMed  Google Scholar 

de Wit K, D’Arsigny CL (2023) Risk stratification of acute pulmonary embolism. J Thromb Haemost 21:3016–3023

Article  PubMed  Google Scholar 

Mojaddedi S, Jamil J, Bishev D, Essilfie-Quaye K, Elgendy IY (2024) Risk stratification and management of intermediate- and high-risk pulmonary embolism. J Clin Med 13:5583

Article  CAS  PubMed  PubMed Central