Why internists should care about : recapitulating gastric cancer prevention

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834

Article  PubMed  Google Scholar 

Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1(8336):1273–1275

PubMed  CAS  Google Scholar 

Malfertheiner P (2018) Helicobacter pylori treatment for gastric cancer prevention. N Engl J Med 378(12):1154–1156. https://doi.org/10.1056/NEJMe1800147

Article  PubMed  Google Scholar 

Wang XY, Wang LL, Xu L, Liang SZ, Yu MC, Zhang QY, Dong QJ (2023) Evaluation of polygenic risk score for risk prediction of gastric cancer. World J Gastrointest Oncol 15(2):276–285. https://doi.org/10.4251/wjgo.v15.i2.276

Article  PubMed  PubMed Central  Google Scholar 

Park JY (2025) Population-based helicobacter pylori screen-and-treat strategies for gastric cancer prevention: guidance on implementation. Lyon (FR): International Agency for Research on Cancer. (PMID: 40601795)

Usui Y, Taniyama Y, Endo M et al (2023) Helicobacter pylori, Homologous-recombination genes, and gastric cancer. N Engl J Med 388(13):1181–1190. https://doi.org/10.1056/NEJMoa2211807

Article  PubMed  CAS  Google Scholar 

Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, Smith SI, Suerbaum S (2023) Helicobacter pylori infection. Nat Rev Dis Primers 9(1):19. https://doi.org/10.1038/s41572-023-00431-8

Article  PubMed  PubMed Central  Google Scholar 

Megraud F, Bessede E, Varon C (2015) Helicobacter pylori infection and gastric carcinoma. Clin Microbiol Infect 21(11):984–990. https://doi.org/10.1016/j.cmi.2015.06.004

Article  PubMed  CAS  Google Scholar 

de Martel C, Georges D, Bray F, Ferlay J, Clifford GM (2020) Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health 8(2):e180–e190. https://doi.org/10.1016/S2214-109X(19)30488-7

Article  PubMed  Google Scholar 

Moss SF (2017) The clinical evidence linking Helicobacter pylori to gastric cancer. Cell Mol Gastroenterol Hepatol 3(2):183–191. https://doi.org/10.1016/j.jcmgh.2016.12.001

Article  PubMed  Google Scholar 

Ford AC, Yuan Y, Moayyedi P (2020) Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis. Gut 69(12):2113–2121. https://doi.org/10.1136/gutjnl-2020-320839

Article  PubMed  Google Scholar 

Ford AC, Yuan Y, Park JY, Forman D, Moayyedi P (2025) Eradication therapy to prevent gastric cancer in Helicobacterpylori-positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies. Gastroenterology. https://doi.org/10.1053/j.gastro.2024.12.033

Article  PubMed  Google Scholar 

Chen YC, Malfertheiner P, Yu HT et al (2024) Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology 166(4):605–619. https://doi.org/10.1053/j.gastro.2023.12.022

Article  PubMed  Google Scholar 

Park JY, Georges D, Alberts CJ, Bray F, Clifford G, Baussano I (2025) Global lifetime estimates of expected and preventable gastric cancers across 185 countries. Nat Med. https://doi.org/10.1038/s41591-025-03793-6

Article  PubMed  PubMed Central  Google Scholar 

Collatuzzo G, Fiorini G, Vaira B, Violante FS, Farioli A, Boffetta P (2021) The role of the occupational physician in controlling gastric cancer attributable to Helicobacter pylori infection: a review. Prev Med Rep 24:101527. https://doi.org/10.1016/j.pmedr.2021.101527

Article  PubMed  PubMed Central  Google Scholar 

Moss SF, Shah SC, Tan MC, El-Serag HB (2024) Evolving concepts in Helicobacter pylori management. Gastroenterology 166(2):267–283. https://doi.org/10.1053/j.gastro.2023.09.047

Article  PubMed  Google Scholar 

Mulder DT, O’Mahony JF, Sun D et al (2025) The optimal age of Helicobacter pylori screen-and-treat for gastric cancer prevention in the United States. Helicobacter 30(3):e70039. https://doi.org/10.1111/hel.70039

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Zhu S, Liu Y, He D, Liu Y, Li H (2025) Economic evaluation of preventing gastric cancer by eliminating Helicobacter pylori infection in China. Scand J Gastroenterol 60(4):327–335. https://doi.org/10.1080/00365521.2025.2473020

Article  PubMed  Google Scholar 

Malfertheiner P, Megraud F, Rokkas T et al (2022) Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. https://doi.org/10.1136/gutjnl-2022-327745

Article  PubMed  Google Scholar 

Di Ciaula A, Scaccianoce G, Venerito M, Zullo A, Bonfrate L, Rokkas T, Portincasa P (2017) Eradication rates in Italian subjects heterogeneously managed for Helicobacter pylori infection. Time to abandon empiric treatments in Southern Europe. J Gastrointest Liver Dis 26(2):129–137. https://doi.org/10.15403/jgld.2014.1121.262.itl

Article  Google Scholar 

Shah S, Cappell K, Sedgley R, Pelletier C, Jacob R, Bonafede M, Yadlapati R (2023) Diagnosis and treatment patterns among patients with newly diagnosed Helicobacter pylori infection in the United States 2016–2019. Sci Rep 13(1):1375. https://doi.org/10.1038/s41598-023-28200-3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhu M, Xu X, Cai P et al (2025) Global population structure, virulence factors and antibiotic resistance of Helicobacter pylori: a pooled analysis of 4067 isolates from 76 countries. Helicobacter 30(2):e70025. https://doi.org/10.1111/hel.70025

Article  PubMed  CAS  Google Scholar 

Li C, He L, Wang A, Chen S, Fu P, Wang C (2024) Antibiotic resistance and virulence genes in Helicobacter pylori strains isolated from children in Shanghai, China (2019–2022). Int J Med Microbiol 315:151622. https://doi.org/10.1016/j.ijmm.2024.151622

Article  PubMed  CAS  Google Scholar 

Botija G, Barrio J, Martinez-Escribano B et al (2025) Evolution of antibiotic resistance pattern of Helicobacter pylori in Spanish children: a 10-year multicenter study. J Pediatr Gastroenterol Nutr. https://doi.org/10.1002/jpn3.70123

Article  PubMed  Google Scholar 

Kamal A, Ghazy RM, Sherief D, Ismail A, Ellakany WI (2023) Helicobacter pylori eradication rates using clarithromycin and levofloxacin-based regimens in patients with previous COVID-19 treatment: a randomized clinical trial. BMC Infect Dis 23(1):36. https://doi.org/10.1186/s12879-023-07993-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rutter MD, Brookes M, Lee TJ, Rogers P, Sharp L (2021) Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a national endoscopy database analysis. Gut 70(3):537–543. https://doi.org/10.1136/gutjnl-2020-322179

Article  PubMed  CAS  Google Scholar 

Ruan W, Fishman DS, Lerner DG, Engevik MA, Elmunzer BJ, Walsh CM, International Pediatric Endoscopy C-A (2020) Changes in pediatric endoscopic practice during the coronavirus disease 2019 pandemic: results from an international survey. Gastroenterology 159(4):1547–1550. https://doi.org/10.1053/j.gastro.2020.05.068

Article  PubMed  CAS  Google Scholar 

Olmedo L, Calvet X, Gene E et al (2024) Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut 74(1):15–25. https://doi.org/10.1136/gutjnl-2024-332804

Article  PubMed  CAS  Google Scholar 

Zaramella A, Arcidiacono D, Duci M et al (2024) Predictive value of a gastric microbiota dysbiosis test for stratifying cancer risk in atrophic gastritis patients. Nutrients. https://doi.org/10.3390/nu17010142

Article  PubMed  PubMed Central  Google Scholar 

Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C (2018) Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Gut 67(2):226–236. https://doi.org/10.1136/gutjnl-2017-314205

Article 

Comments (0)

No login
gif