Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834
Warren JR, Marshall B (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1(8336):1273–1275
Malfertheiner P (2018) Helicobacter pylori treatment for gastric cancer prevention. N Engl J Med 378(12):1154–1156. https://doi.org/10.1056/NEJMe1800147
Wang XY, Wang LL, Xu L, Liang SZ, Yu MC, Zhang QY, Dong QJ (2023) Evaluation of polygenic risk score for risk prediction of gastric cancer. World J Gastrointest Oncol 15(2):276–285. https://doi.org/10.4251/wjgo.v15.i2.276
Article PubMed PubMed Central Google Scholar
Park JY (2025) Population-based helicobacter pylori screen-and-treat strategies for gastric cancer prevention: guidance on implementation. Lyon (FR): International Agency for Research on Cancer. (PMID: 40601795)
Usui Y, Taniyama Y, Endo M et al (2023) Helicobacter pylori, Homologous-recombination genes, and gastric cancer. N Engl J Med 388(13):1181–1190. https://doi.org/10.1056/NEJMoa2211807
Article PubMed CAS Google Scholar
Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, Smith SI, Suerbaum S (2023) Helicobacter pylori infection. Nat Rev Dis Primers 9(1):19. https://doi.org/10.1038/s41572-023-00431-8
Article PubMed PubMed Central Google Scholar
Megraud F, Bessede E, Varon C (2015) Helicobacter pylori infection and gastric carcinoma. Clin Microbiol Infect 21(11):984–990. https://doi.org/10.1016/j.cmi.2015.06.004
Article PubMed CAS Google Scholar
de Martel C, Georges D, Bray F, Ferlay J, Clifford GM (2020) Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health 8(2):e180–e190. https://doi.org/10.1016/S2214-109X(19)30488-7
Moss SF (2017) The clinical evidence linking Helicobacter pylori to gastric cancer. Cell Mol Gastroenterol Hepatol 3(2):183–191. https://doi.org/10.1016/j.jcmgh.2016.12.001
Ford AC, Yuan Y, Moayyedi P (2020) Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis. Gut 69(12):2113–2121. https://doi.org/10.1136/gutjnl-2020-320839
Ford AC, Yuan Y, Park JY, Forman D, Moayyedi P (2025) Eradication therapy to prevent gastric cancer in Helicobacterpylori-positive individuals: systematic review and meta-analysis of randomized controlled trials and observational studies. Gastroenterology. https://doi.org/10.1053/j.gastro.2024.12.033
Chen YC, Malfertheiner P, Yu HT et al (2024) Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology 166(4):605–619. https://doi.org/10.1053/j.gastro.2023.12.022
Park JY, Georges D, Alberts CJ, Bray F, Clifford G, Baussano I (2025) Global lifetime estimates of expected and preventable gastric cancers across 185 countries. Nat Med. https://doi.org/10.1038/s41591-025-03793-6
Article PubMed PubMed Central Google Scholar
Collatuzzo G, Fiorini G, Vaira B, Violante FS, Farioli A, Boffetta P (2021) The role of the occupational physician in controlling gastric cancer attributable to Helicobacter pylori infection: a review. Prev Med Rep 24:101527. https://doi.org/10.1016/j.pmedr.2021.101527
Article PubMed PubMed Central Google Scholar
Moss SF, Shah SC, Tan MC, El-Serag HB (2024) Evolving concepts in Helicobacter pylori management. Gastroenterology 166(2):267–283. https://doi.org/10.1053/j.gastro.2023.09.047
Mulder DT, O’Mahony JF, Sun D et al (2025) The optimal age of Helicobacter pylori screen-and-treat for gastric cancer prevention in the United States. Helicobacter 30(3):e70039. https://doi.org/10.1111/hel.70039
Article PubMed PubMed Central Google Scholar
Li Y, Zhu S, Liu Y, He D, Liu Y, Li H (2025) Economic evaluation of preventing gastric cancer by eliminating Helicobacter pylori infection in China. Scand J Gastroenterol 60(4):327–335. https://doi.org/10.1080/00365521.2025.2473020
Malfertheiner P, Megraud F, Rokkas T et al (2022) Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut. https://doi.org/10.1136/gutjnl-2022-327745
Di Ciaula A, Scaccianoce G, Venerito M, Zullo A, Bonfrate L, Rokkas T, Portincasa P (2017) Eradication rates in Italian subjects heterogeneously managed for Helicobacter pylori infection. Time to abandon empiric treatments in Southern Europe. J Gastrointest Liver Dis 26(2):129–137. https://doi.org/10.15403/jgld.2014.1121.262.itl
Shah S, Cappell K, Sedgley R, Pelletier C, Jacob R, Bonafede M, Yadlapati R (2023) Diagnosis and treatment patterns among patients with newly diagnosed Helicobacter pylori infection in the United States 2016–2019. Sci Rep 13(1):1375. https://doi.org/10.1038/s41598-023-28200-3
Article PubMed PubMed Central CAS Google Scholar
Zhu M, Xu X, Cai P et al (2025) Global population structure, virulence factors and antibiotic resistance of Helicobacter pylori: a pooled analysis of 4067 isolates from 76 countries. Helicobacter 30(2):e70025. https://doi.org/10.1111/hel.70025
Article PubMed CAS Google Scholar
Li C, He L, Wang A, Chen S, Fu P, Wang C (2024) Antibiotic resistance and virulence genes in Helicobacter pylori strains isolated from children in Shanghai, China (2019–2022). Int J Med Microbiol 315:151622. https://doi.org/10.1016/j.ijmm.2024.151622
Article PubMed CAS Google Scholar
Botija G, Barrio J, Martinez-Escribano B et al (2025) Evolution of antibiotic resistance pattern of Helicobacter pylori in Spanish children: a 10-year multicenter study. J Pediatr Gastroenterol Nutr. https://doi.org/10.1002/jpn3.70123
Kamal A, Ghazy RM, Sherief D, Ismail A, Ellakany WI (2023) Helicobacter pylori eradication rates using clarithromycin and levofloxacin-based regimens in patients with previous COVID-19 treatment: a randomized clinical trial. BMC Infect Dis 23(1):36. https://doi.org/10.1186/s12879-023-07993-8
Article PubMed PubMed Central CAS Google Scholar
Rutter MD, Brookes M, Lee TJ, Rogers P, Sharp L (2021) Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a national endoscopy database analysis. Gut 70(3):537–543. https://doi.org/10.1136/gutjnl-2020-322179
Article PubMed CAS Google Scholar
Ruan W, Fishman DS, Lerner DG, Engevik MA, Elmunzer BJ, Walsh CM, International Pediatric Endoscopy C-A (2020) Changes in pediatric endoscopic practice during the coronavirus disease 2019 pandemic: results from an international survey. Gastroenterology 159(4):1547–1550. https://doi.org/10.1053/j.gastro.2020.05.068
Article PubMed CAS Google Scholar
Olmedo L, Calvet X, Gene E et al (2024) Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut 74(1):15–25. https://doi.org/10.1136/gutjnl-2024-332804
Article PubMed CAS Google Scholar
Zaramella A, Arcidiacono D, Duci M et al (2024) Predictive value of a gastric microbiota dysbiosis test for stratifying cancer risk in atrophic gastritis patients. Nutrients. https://doi.org/10.3390/nu17010142
Article PubMed PubMed Central Google Scholar
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C (2018) Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Gut 67(2):226–236. https://doi.org/10.1136/gutjnl-2017-314205
Comments (0)