Study on the regulatory effects of and genes on the synthesis of LC-PUFAs, based on the transcriptome changes induced by fluridone in OUC86

Arias RS, Dayan FE, Michel A, Howell J, Scheffler BE (2006) Characterization of a higher plant herbicide-resistant phytoene desaturase and its use as a selectable marker. Plant Biotechnol J 4:263–273. https://doi.org/10.1111/j.1467-7652.2006.00179.x

Article  CAS  PubMed  Google Scholar 

Chan AP, Crabtree J, Zhao Q, Lorenzi H, Orvis J, Puiu D, Melake-Berhan A, Jones KM, Redman J, Chen G, Cahoon EB, Gedil M, Stanke M, Haas BJ, Wortman JR, Fraser-Liggett CM, Ravel J, Rabinowicz PD (2010) Draft genome sequence of the oilseed species Ricinus communis. Nat Biotechnol 28:951-U3. https://doi.org/10.1038/nbt.1674

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chi G, Xu Y, Cao X, Li Z, Cao M, Chisti Y, He N (2022) Production of polyunsaturated fatty acids by Schizochytrium (Aurantiochytrium) spp.. Biotechnol Adv 55:107897. https://doi.org/10.1016/j.biotechadv.2021.107897

Article  CAS  PubMed  Google Scholar 

Das UN (2021) Bioactive lipids in COVID-19-further evidence. Arch Med Res 52:107–120. https://doi.org/10.1016/j.arcmed.2020.09.006

Article  CAS  PubMed  Google Scholar 

Davidson NM, Oshlack A (2014) Corset: enabling differential gene expression analysis for de novo assembled transcriptomes. Genome Biol 15:410. https://doi.org/10.1186/s13059-014-0410-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Boer VC, Houten SM (2014) A mitochondrial expatriate: nuclear pyruvate dehydrogenase. Cell 158:9–10. https://doi.org/10.1016/j.cell.2014.06.018

Article  CAS  PubMed  Google Scholar 

Dyall SC (2015) Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA. DPA DHA Front Aging Neurosci 7:52. https://doi.org/10.3389/fnagi.2015.00052

Article  PubMed  Google Scholar 

García-Montalvo IA, MLÁ CO (2023) Parenteral supplementation with EPA/DHA omega-3 fatty acids improves recovery prognosis in critically ill patients. Nutr Hosp 40(1):3–12. https://doi.org/10.20960/nh.04227

Article  CAS  PubMed  Google Scholar 

Grabherr MG, Haas BJ, Yassour M, Levin JZ, Thompson DA, Amit I, Adiconis X, Fan L, Raychowdhury R, Zeng QD, Chen ZH, Mauceli E, Hacohen N, Gnirke A, Rhind N, di Palma F, Birren BW, Nusbaum C, Lindblad-Toh K, Friedman N, Regev A (2011) Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 29:644-U130. https://doi.org/10.1186/1471-2105-12-323

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grevengoed TJ, Klett EL, Coleman RA (2014) Acyl-CoA metabolism and partitioning. Annu Rev Nutr 34(34):1–30. https://doi.org/10.1146/annurev-nutr-071813-105541

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo H, Lin W, Wu X, Wang L, Zhang D, Li L, Li D, Tang R, Yang L, Qiu Y (2020) Survival strategies of Wuchang bream (Megalobrama amblycephala) juveniles for chronic ammonia exposure: antioxidant defense and the synthesis of urea and glutamine. Comp Biochem Physiol C Toxicol Pharmacol 230:108707. https://doi.org/10.1016/j.cbpc.2020.108707

Article  CAS  PubMed  Google Scholar 

Gupta A, Barrow CJ, Puri M (2012) Omega-3 biotechnology: Thraustochytrids as a novel source of omega-3 oils. Biotechnol Adv 30:1733–1745. https://doi.org/10.1016/j.biotechadv.2012.02.014

Article  CAS  PubMed  Google Scholar 

Hao X, Chen W, Amato A, Jouhet J, Maréchal E, Moog D, Hu H, Jin H, You L, Huang F, Moosburner M (2022) Multiplexed CRISPR/Cas9 editing of the long-chain acyl-CoA synthetase family in the diatom Phaeodactylum tricornutum reveals that mitochondrial ptACSL3 is involved in the synthesis of storage lipids. New Phytol 233(4):1797–812

Article  CAS  PubMed  Google Scholar 

Huang JZ, Aki T, Hachida K, Yokochi T, Kawamoto S, Shigeta S, Ono K, Suzuki O (2001) Profile of polyunsaturated fatty acids produced by Thraustochytrium sp. KK17-3. J Am Oil Chem Soc 78:605–610. https://doi.org/10.1007/s11746-001-0312-1

Article  CAS  Google Scholar 

Ichihara K, Kobayashi N, Saito K (2003) Lipid synthesis and acyl-CoA synthetase in developing rice seeds. Lipids 38:881–4. https://doi.org/10.1007/s11745-003-1139-0

Article  CAS  PubMed  Google Scholar 

Ikeda M, Nakagawa S (2003) The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol 62:99–109. https://doi.org/10.1007/s00253-003-1328-1

Article  CAS  PubMed  Google Scholar 

Jia J, Zhao S, Kong X, Li Y, Zhao G, He W, Appels R, Pfeifer M, Tao Y, Zhang X, Jing R (2013) Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature 496(7443):91–5. https://doi.org/10.1038/nature12028

Article  CAS  PubMed  Google Scholar 

Kaur G, Cameron-Smith D, Garg M, Sinclair AJ (2011) Docosapentaenoic acid (22:5n–3): a review of its biological effects. Prog Lipid Res 50:28–34. https://doi.org/10.1016/j.plipres.2010.07.004

Article  CAS  PubMed  Google Scholar 

Laje K, Seger M, Dungan B, Cooke P, Polle J, Holguin FO (2019a) Phytoene accumulation in the novel microalga Chlorococcum sp using the pigment synthesis inhibitor fluridone. Mar Drugs 17(3):187. https://doi.org/10.3390/md17030187

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li B, Dewey CN (2011) RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bmc Bioinform. https://doi.org/10.1186/1471-2105-12-323

Article  Google Scholar 

Ling XP, Zhou H, Yang QH, Yu SY, Li J, Li ZP, He N, Chen CX, Lu YH (2020) Functions of Enyolreductase (ER) domains of PKS cluster in lipid synthesis and enhancement of PUFAs accumulation in Schizochytrium limacinum SR21 using triclosan as a regulator of ER. Microorganisms. https://doi.org/10.3390/microorganisms8020300

Article  PubMed  PubMed Central  Google Scholar 

Listowsky I, Abramovitz M, Homma H, Niitsu Y (1988) Intracellular binding and transport of hormones and xenobiotics by glutathione-S-transferases. Drug Metab Rev 19:305–18. https://doi.org/10.3109/03602538808994138

Article  CAS  PubMed  Google Scholar 

Liu L, Bai MH, Zhang S, Li JT, Liu XH, Sen B, Wang GY (2021) ARTP mutagenesis of Schizochytrium sp. PKU#Mn4 and Clethodim-based mutant screening for enhanced Docosahexaenoic acid accumulation. Mar Drugs. https://doi.org/10.3390/md19100564

Article  PubMed  PubMed Central  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–8. https://doi.org/10.1006/meth.2001.1262

Article  CAS  PubMed  Google Scholar 

Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genom Biol. https://doi.org/10.1186/s13059-014-0550-8

Article  Google Scholar 

Ma W, Zhang ZY, Yang WQ, Huang PW, Gu Y, Sun XM, Huang H (2023) Enhanced docosahexaenoic acid production from cane molasses by engineered and adaptively evolved Schizochytrium sp. Biores Technol. https://doi.org/10.1016/j.biortech.2023.128833

Article  Google Scholar 

Marchan LF, Chang KJ, Nichols PD, Mitchell WJ, Polglase JL, Gutierrez T (2018) Taxonomy, ecology and biotechnological applications of thraustochytrids: a review. Biotechnol Adv 36(1):26–46

Article  Google Scholar 

Meyer A, Cirpus P, Ott C, Schlecker R, ZäHRINGER U, HEINZ E (2003) Biosynthesis of docosahexaenoic acid in biochemical and molecular evidence for the involvement of a Δ4-fatty acyl group desaturase. Biochemistry 42:9779–9788. https://doi.org/10.1021/bi034731y

Article  CAS  PubMed  Google Scholar 

Oboh A, Kabeya N, Carmona-Antoñanzas G, Castro LF, Dick JR, Tocher DR, Monroig O (2017) Two alternative pathways for docosahexaenoic acid (DHA, 22: 6n–3) biosynthesis are widespread among teleost fish. Sci Rep 7(1):3889.

Comments (0)

No login
gif