Minimally invasive biomarkers for triaging lung nodules—challenges and future perspectives

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660

Article  CAS  PubMed  Google Scholar 

Sharma, R. (2022). Mapping of global, regional and national incidence, mortality and mortality-to-incidence ratio of lung cancer in 2020 and 2050. International Journal of Clinical Oncology, 27(4), 665–675.

Article  PubMed  PubMed Central  Google Scholar 

Shlomi, D., Peled, N., Schwarz, Y. A., Soo Hoo, G. W., Batra, R. K., Fink, G., et al. (2018). Non-invasive early detection of malignant pulmonary nodules by FISH-based sputum test. Cancer Genetics, 226–227, 1–10. https://doi.org/10.1016/j.cancergen.2018.04.118

Article  PubMed  Google Scholar 

Lancaster, H. L., Heuvelmans, M. A., & Oudkerk, M. (2022). Low-dose computed tomography lung cancer screening: Clinical evidence and implementation research. Journal of Internal Medicine, 292(1), 68–80. https://doi.org/10.1111/joim.13480

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadique, S., Jain, P., Hadi, Y., Baig, A., & Parker, J. E. (2020). Utility of FDG PET/CT for assessment of lung nodules identified during low dose computed tomography screening. BMC Medical Imaging, 20, 1–6.

Article  Google Scholar 

Krist, A. H., Davidson, K. W., Mangione, C. M., Barry, M. J., Cabana, M., Caughey, A. B., et al. (2021). Screening for lung cancer: US Preventive Services Task Force recommendation statement. JAMA, 325(10), 962–970.

Article  PubMed  Google Scholar 

Silva, M., Milanese, G., Ledda, R. E., Pastorino, U., & Sverzellati, N. (2021). Screen-detected solid nodules: From detection of nodule to structured reporting. Translational Lung Cancer Research, 10(5), 2335.

Article  PubMed  PubMed Central  Google Scholar 

Wilson, R., & Devaraj, A. (2017). Radiomics of pulmonary nodules and lung cancer. Transl Lung Cancer Res, 6(1), 86–91. https://doi.org/10.21037/tlcr.2017.01.04

Article  PubMed  PubMed Central  Google Scholar 

Herring, A., Chelala, L., & White, C. S. (2023). Lung RADS: Lessons learned and strategies for the optimization of lung cancer screening. Current Pulmonology Reports, 12(4), 181–189.

Article  Google Scholar 

Winkler Wille, M. M., van Riel, S. J., Saghir, Z., Dirksen, A., Pedersen, J. H., Jacobs, C., et al. (2015). Predictive accuracy of the PanCan lung cancer risk prediction model-external validation based on CT from the Danish lung cancer screening trial. European Radiology, 25, 3093–3099.

Article  PubMed  Google Scholar 

Marmor, H. N., Zorn, J. T., Deppen, S. A., Massion, P. P., & Grogan, E. L. (2021). Biomarkers in lung cancer screening: A narrative review. Current Challenges in Thoracic Surgery, 5, 5.

Article  PubMed  PubMed Central  Google Scholar 

Stephens, E. K., Sigcha, J. G., Lopez-Loo, K., Yang, I. A., Marshall, H. M., & Fong, K. M. (2023). Biomarkers of lung cancer for screening and in never-smokers—a narrative review. Translational Lung Cancer Research, 12(10), 2129.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazzone, P. J., Bach, P. B., Carey, J., Schonewolf, C. A., Bognar, K., Ahluwalia, M. S., Cruz-Correa, M., Gierada, D., Kotagiri, S., Lloyd, k., Maldonado, F., Ortendahl, J., Sequist, L., Silvestri, G. A., Tanner, N., Thompson, J. C., Vachani, A., Wong, K. K., Zaidi, A. H... & Pike, L. R. G. (2024). Clinical validation of a cell-free DNA fragmentome assay for augmentation of lung cancer early detection. Cancer Discovery, 14(11), 2224–2242. https://doi.org/10.1158/2159-8290.CD-24-0519

Xu, S., Ge, J., Liu, X., He, Q., Xu, D., Cao, W., et al. (2023). The predictive value of chest computed tomography images, tumor markers, and metabolomics in the identification of benign and malignant pulmonary nodules. Journal of Thoracic Disease, 15(5), 2668.

Article  PubMed  PubMed Central  Google Scholar 

Santarpia, M., Liguori, A., D’Aveni, A., Karachaliou, N., Gonzalez-Cao, M., Daffinà, M. G., et al. (2018). Liquid biopsy for lung cancer early detection. Journal of Thoracic Disease, 10(Suppl 7), S882-s897. https://doi.org/10.21037/jtd.2018.03.81

Article  PubMed  PubMed Central  Google Scholar 

Yu, Q., Chen, J., Fu, W., Muhammad, K. G., Li, Y., Liu, W., et al. (2022). Smartphone-based platforms for clinical detections in lung-cancer-related exhaled breath biomarkers: A review. Biosensors, 12(4), 223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang, L., Li, J., & Zhang, R. (2022). Liquid biopsy for early diagnosis of non-small cell lung carcinoma: Recent research and detection technologies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1877(3), 188729. https://doi.org/10.1016/j.bbcan.2022.188729

Article  CAS  PubMed  Google Scholar 

Alix-Panabières, C., & Pantel, K. (2021). Liquid biopsy: From discovery to clinical application. Cancer Discovery, 11(4), 858–873. https://doi.org/10.1158/2159-8290.CD-20-1311

Article  PubMed  Google Scholar 

Hansell, D. M., Bankier, A. A., MacMahon, H., McLoud, T. C., Muller, N. L., & Remy, J. (2008). Fleischner society: Glossary of terms for thoracic imaging. Radiology, 246(3), 697. https://doi.org/10.1148/radiol.2462070712

Article  PubMed  Google Scholar 

Walter, J. E., Heuvelmans, M. A., de Jong, P. A., Vliegenthart, R., van Ooijen, P. M. A., Peters, R. B., et al. (2016). Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: Analysis of data from the randomised, controlled NELSON trial. The Lancet Oncology, 17(7), 907–916. https://doi.org/10.1016/s1470-2045(16)30069-9

Article  PubMed  Google Scholar 

Loverdos, K., Fotiadis, A., Kontogianni, C., Iliopoulou, M., & Gaga, M. (2019). Lung nodules: A comprehensive review on current approach and management. Annals of Thoracic Medicine, 14(4), 226–238. https://doi.org/10.4103/atm.ATM_110_19

Article  PubMed  PubMed Central  Google Scholar 

Walter, J. E., Heuvelmans, M. A., Yousaf-Khan, U., Dorrius, M. D., Thunnissen, E., Schermann, A., et al. (2018). New subsolid pulmonary nodules in lung cancer screening: The NELSON Trial. Journal of Thoracic Oncology, 13(9), 1410–1414. https://doi.org/10.1016/j.jtho.2018.05.006

Article  PubMed  Google Scholar 

Mazzone, P. J., & Lam, L. (2022). Evaluating the patient with a pulmonary nodule: A review. JAMA, 327(3), 264–273. https://doi.org/10.1001/jama.2021.24287

Article  PubMed  Google Scholar 

Shah, P. K., Austin, J. H., White, C. S., Patel, P., Haramati, L. B., Pearson, G. D., et al. (2003). Missed non–small cell lung cancer: Radiographic findings of potentially resectable lesions evident only in retrospect. Radiology, 226(1), 235–241.

Article  PubMed  Google Scholar 

Walter, J. E., Heuvelmans, M. A., de Bock, G. H., Yousaf-Khan, U., Groen, H. J., van der Aalst, C. M., et al. (2018). Characteristics of new solid nodules detected in incidence screening rounds of low-dose CT lung cancer screening: The NELSON study. Thorax, 73(8), 741–747. https://doi.org/10.1136/thoraxjnl-2017-211376

Article  PubMed  Google Scholar 

Alpert, J. B., & Ko, J. P. (2018). Management of incidental lung nodules: Current strategy and rationale. Radiologic Clinics of North America, 56(3), 339–351. https://doi.org/10.1016/j.rcl.2018.01.002

Article  PubMed  Google Scholar 

de Koning, H. J., van der Aalst, C. M., de Jong, P. A., Scholten, E. T., Nackaerts, K., Heuvelmans, M. A., et al. (2020). Reduced lung-cancer mortality with volume CT screening in a randomized trial. New England Journal of Medicine, 382(6), 503–513. https://doi.org/10.1056/NEJMoa1911793

Article  PubMed  Google Scholar 

Zhang, R., Tian, P., Qiu, Z., Liang, Y., & Li, W. (2020). The growth feature and its diagnostic value for benign and malignant pulmonary nodules met in routine clinical practice. Journal of Thoracic Disease, 12(5), 2019–2030. https://doi.org/10.21037/jtd-19-3591

Article  PubMed  PubMed Central  Google Scholar 

Lebrett, M. B., Crosbie, E. J., Smith, M. J., Woodward, E. R., Evans, D. G., & Crosbie, P. A. J. (2021). Targeting lung cancer screening to individuals at greatest risk: The role of genetic factors. Journal of Medical Genetics, 58(4), 217–226. https://doi.org/10.1136/jmedgenet-2020-107399

Article  CAS  PubMed  Google Scholar 

Jonas, D. E., Reuland, D. S., Reddy, S. M., Nagle, M., Clark, S. D., Weber, R. P., et al. (2021). Screening for lung cancer with low-dose computed tomography: Updated evidence report and systematic review for the US preventive services task force. JAMA, 325(10), 971–987. https://doi.org/10.1001/jama.2021.0377

Article  PubMed  Google Scholar 

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