p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair

Ning, S., & Wang, L. (2019). The Multifunctional Protein P62 and Its Mechanistic Roles in Cancers. Current Cancer Drug Targets, 19(6), 468–478. https://doi.org/10.2174/1568009618666181016164920

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katsuragi, Y., Ichimura, Y., & Komatsu, M. (2015). P62/SQSTM1 Functions as a Signaling Hub and an Autophagy Adaptor. FEBS Journal, 282(24), 4672–4678. https://doi.org/10.1111/febs.13540

Article  CAS  PubMed  Google Scholar 

Islam, M. A., Sooro, M. A., & Zhang, P. (2018). Autophagic Regulation of P62 Is Critical for Cancer Therapy. International Journal of Molecular Sciences, 19(5). https://doi.org/10.3390/ijms19051405.

Myeku, N., & Figueiredo-Pereira, M. E. (2011). Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy: Association with Sequestosome 1/P62. Journal of Biological Chemistry, 286(25), 22426–22440. https://doi.org/10.1074/jbc.M110.149252

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wurzer, B., Zaffagnini, G., Fracchiolla, D., Turco, E., Abert, C., Romanov, J., & Martens, S. (2015). Oligomerization of P62 Allows for Selection of Ubiquitinated Cargo and Isolation Membrane during Selective Autophagy. eLife, 4, e08941. https://doi.org/10.7554/eLife.08941

Article  PubMed  PubMed Central  Google Scholar 

Sanz, L., Sanchez, P., Lallena, M. J., Diaz-Meco, M. T., & Moscat, J. (1999). The Interaction of P62 with RIP Links the Atypical PKCs to NF-kappaB Activation. EMBO Journal, 18(11), 3044–3053.

CAS  PubMed  PubMed Central  Google Scholar 

Wooten, M. W., Geetha, T., Seibenhener, M. L., Babu, J. R., Diaz-Meco, M. T., & Moscat, J. (2005). The P62 Scaffold Regulates Nerve Growth Factor-Induced NF-kappaB Activation by Influencing TRAF6 Polyubiquitination. Journal of Biological Chemistry, 280(42), 35625–35629.

CAS  PubMed  Google Scholar 

Feng, Y., & Longmore, G. D. (2005). The LIM Protein Ajuba Influences Interleukin-1-Induced NF-kappaB Activation by Affecting the Assembly and Activity of the Protein Kinase Czeta/P62/TRAF6 Signaling Complex. Molecular and Cellular Biology, 25(10), 4010–4022.

CAS  PubMed  PubMed Central  Google Scholar 

Pankiv, S., Lamark, T., Bruun, J.-A., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2010). Nucleocytoplasmic Shuttling of P62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies. Journal of Biological Chemistry, 285(8), 5941–5953. https://doi.org/10.1074/jbc.M109.039925

Article  CAS  PubMed  Google Scholar 

You, Z., Jiang, W.-X., Qin, L.-Y., Gong, Z., Wan, W., Li, J., Wang, Y., Zhang, H., Peng, C., Zhou, T., Tang, C., & Liu, W. (2019). Requirement for P62 Acetylation in the Aggregation of Ubiquitylated Proteins under Nutrient Stress. Nature Communications, 10(1), 5792. https://doi.org/10.1038/s41467-019-13718-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turco, E., Savova, A., Gere, F., Ferrari, L., Romanov, J., Schuschnig, M., & Martens, S. (2021). Reconstitution Defines the Roles of P62, NBR1 and TAX1BP1 in Ubiquitin Condensate Formation and Autophagy Initiation. Nature Communications, 12(1), 5212. https://doi.org/10.1038/s41467-021-25572-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lamark, T., Svenning, S., & Johansen, T. (2017). Regulation of Selective Autophagy: The P62/SQSTM1 Paradigm. Essays in Biochemistry, 61(6), 609–624. https://doi.org/10.1042/EBC20170035

Article  PubMed  Google Scholar 

Zhao, Y., Zhu, Q., Bu, X., Zhou, Y., Bai, D., Guo, Q., Gao, Y., & Lu, N. (2020). Triggering Apoptosis by Oroxylin A through Caspase-8 Activation and P62/SQSTM1 Proteolysis. Redox Biology, 29, 101392. https://doi.org/10.1016/j.redox.2019.101392

Article  CAS  PubMed  Google Scholar 

Vadlamudi, R. K., & Shin, J. (1998). Genomic Structure and Promoter Analysis of the P62 Gene Encoding a Non-Proteasomal Multiubiquitin Chain Binding Protein. FEBS Letters, 435(2–3), 138–142.

CAS  PubMed  Google Scholar 

Pölönen, P., Jawahar Deen, A., Leinonen, H. M., Jyrkkänen, H.-K., Kuosmanen, S., Mononen, M., Jain, A., Tuomainen, T., Pasonen-Seppänen, S., Hartikainen, J. M., Mannermaa, A., Nykter, M., Tavi, P., Johansen, T., Heinäniemi, M., & Levonen, A.-L. (2019). Nrf2 and SQSTM1/P62 Jointly Contribute to Mesenchymal Transition and Invasion in Glioblastoma. Oncogene, 38(50), 7473–7490. https://doi.org/10.1038/s41388-019-0956-6

Article  CAS  PubMed  Google Scholar 

Zhang, J., Yang, Z., & Dong, J. (2016). P62: An Emerging Oncotarget for Osteolytic Metastasis. J. Bone Oncol., 5(1), 30–37. https://doi.org/10.1016/j.jbo.2016.01.003

Article  PubMed  PubMed Central  Google Scholar 

Moscat, J., Karin, M., & Diaz-Meco, M. T. (2016). P62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell, 167(3), 606–609. https://doi.org/10.1016/j.cell.2016.09.030

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moscat, J., & Diaz-Meco, M. T. (2009). P62 at the Crossroads of Autophagy, Apoptosis, and Cancer. Cell, 137(6), 1001–1004. https://doi.org/10.1016/j.cell.2009.05.023

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aishima, S., Fujita, N., Mano, Y., Iguchi, T., Taketomi, A., Maehara, Y., Oda, Y., & Tsuneyoshi, M. (2010). P62+ Hyaline Inclusions in Intrahepatic Cholangiocarcinoma Associated with Viral Hepatitis or Alcoholic Liver Disease. American Journal of Clinical Pathology, 134(3), 457–465. https://doi.org/10.1309/AJCP53YVVJCNDZIR

Article  PubMed  Google Scholar 

Ellis, R. A., Horswell, S., Ness, T., Lumsdon, J., Tooze, S. A., Kirkham, N., Armstrong, J. L., & Lovat, P. E. (2014). Prognostic Impact of P62 Expression in Cutaneous Malignant Melanoma. The Journal of Investigative Dermatology, 134(5), 1476–1478. https://doi.org/10.1038/jid.2013.497

Article  CAS  PubMed  Google Scholar 

Mohamed, A., Ayman, A., Deniece, J., Wang, T., Kovach, C., Siddiqui, M. T., & Cohen, C. (2015). P62/Ubiquitin IHC Expression Correlated with Clinicopathologic Parameters and Outcome in Gastrointestinal Carcinomas. Frontiers in Oncology, 5, 70. https://doi.org/10.3389/fonc.2015.00070

Article  PubMed  PubMed Central  Google Scholar 

Inoue, D., Suzuki, T., Mitsuishi, Y., Miki, Y., Suzuki, S., Sugawara, S., Watanabe, M., Sakurada, A., Endo, C., Uruno, A., Sasano, H., Nakagawa, T., Satoh, K., Tanaka, N., Kubo, H., Motohashi, H., & Yamamoto, M. (2012). Accumulation of P62/SQSTM1 Is Associated with Poor Prognosis in Patients with Lung Adenocarcinoma. Cancer Science, 103(4), 760–766. https://doi.org/10.1111/j.1349-7006.2012.02216.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schläfli, A. M., Adams, O., Galván, J. A., Gugger, M., Savic, S., Bubendorf, L., Schmid, R. A., Becker, K.-F., Tschan, M. P., Langer, R., & Berezowska, S. (2016). Prognostic Value of the Autophagy Markers LC3 and P62/SQSTM1 in Early-Stage Non-Small Cell Lung Cancer. Oncotarget, 7(26), 39544–39555. https://doi.org/10.18632/oncotarget.9647

Adams, O., Dislich, B., Berezowska, S., Schläfli, A. M., Seiler, C. A., Kröll, D., Tschan, M. P., & Langer, R. (2016). Prognostic Relevance of Autophagy Markers LC3B and P62 in Esophageal Adenocarcinomas. Oncotarget, 7(26), 39241–39255. https://doi.org/10.18632/oncotarget.9649

Masuda, G. O., Yashiro, M., Kitayama, K., Miki, Y., Kasashima, H., Kinoshita, H., Morisaki, T., Fukuoka, T., Hasegawa, T., Sakurai, K., Toyokawa, T., Kubo, N., Tanaka, H., Muguruma, K., Masaichi, O., & Hirakawa, K. (2016). Clinicopathological Correlations of Autophagy-Related Proteins LC3, Beclin 1 and P62 in Gastric Cancer. Anticancer Research, 36(1), 129–136.

CAS  PubMed  Google Scholar 

Park, J. M., Huang, S., Wu, T.-T., Foster, N. R., & Sinicrope, F. A. (2013). Prognostic Impact of Beclin 1, P62/Sequestosome 1 and LC3 Protein Expression in Colon Carcinomas from Patients Receiving 5-Fluorouracil as Adjuvant Chemotherapy. Cancer Biology & Therapy, 14(2), 100–107. https://doi.org/10.4161/cbt.22954

Article  CAS  Google Scholar 

Thompson, H. G. R., Harris, J. W., Wold, B. J., Lin, F., & Brody, J. P. (2003). P62 Overexpression in Breast Tumors and Regulation by Prostate-Derived Ets Factor in Breast Cancer Cells. Oncogene, 22(15), 2322–2333.

CAS  PubMed  Google Scholar 

Luo, R.-Z., Yuan, Z.-Y., Li, M., Xi, S.-Y., Fu, J., & He, J. (2013). Accumulation of P62 Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer. OncoTargets Ther., 6, 883–888. https://doi.org/10.2147/OTT.S46222

Article  Google Scholar 

Rolland, P., Madjd, Z., Durrant, L., Ellis, I. O., Layfield, R., & Spendlove, I. (2007). The Ubiquitin-Binding Protein P62 Is Expressed in Breast Cancers Showing Features of Aggressive Disease. Endocrine-Related Cancer, 14(1), 73–80.

PubMed  Google Scholar 

Choi, J., Jung, W., & Koo, J. S. (2013). Expression of Autophagy-Related Markers Beclin-1, Light Chain 3A, Light Chain 3B and P62 According to the Molecular Subtype of Breast Cancer. Histopathology, 62(2), 275–286. https://doi.org/10.1111/his.12002

Article  PubMed 

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