Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer

Hanahan, D. (2022). Hallmarks of cancer: New dimensions. Cancer Discovery, 12(1), 31–46. https://doi.org/10.1158/2159-8290.CD-21-1059

Article  CAS  PubMed  Google Scholar 

Brabletz, T., Kalluri, R., Nieto, M. A., & Weinberg, R. A. (2018). EMT in cancer. Nat Rev Cancer, 18(2), 128–34. https://doi.org/10.1038/nrc.2017.118

Article  CAS  PubMed  Google Scholar 

Wechman, S. L., Emdad, L., Sarkar, D., Das, S. K., & Fisher, P. B. (2020). Vascular mimicry: Triggers, molecular interactions and in vivo models. Adv Cancer Res, 148, 27–67. https://doi.org/10.1016/bs.acr.2020.06.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zang, Y., Chaudhari, K., & Bashaw, G. J. (2021). New insights into the molecular mechanisms of axon guidance receptor regulation and signaling. Curr Top Dev Biol, 142, 147–96. https://doi.org/10.1016/bs.ctdb.2020.11

Article  PubMed  PubMed Central  Google Scholar 

Mehlen, P., Delloye-Bourgeois, C., & Chedotal, A. (2011). Novel roles for Slits and netrins: Axon guidance cues as anticancer targets? Nat Rev Cancer, 11(3), 188–97. https://doi.org/10.1038/nrc3005

Article  CAS  PubMed  Google Scholar 

Zhou, W. J., Geng, Z. H., Chi, S., Zhang, W., Niu, X. F., Lan, S. J., Ma, L., Yang, X., Wang, L. J., Ding, Y. Q., & Geng, J. G. (2011). Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res, 21(4), 609–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tavora, B., Mederer, T., Wessel, K. J., Ruffing, S., Sadjadi, M., Missmahl, M., Ostendorf, B. N., Liu, X., Kim, J. Y., Olsen, O., Welm, A. L., Goodarzi, H., & Tavazoie, S. F. (2020). Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis. Nature, 586(7828), 299–304. https://doi.org/10.1038/s41586-020-2774-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, G., Du, R., Dong, J., Sun, Y., Zhou, F., Feng, F., Feng, B., Han, Y., & Shang, Y. (2023). Cancer associated fibroblast derived SLIT2 drives gastric cancer cell metastasis by activating NEK9. Cell Death Dis, 14(7), 421. https://doi.org/10.1038/s41419-023-05965-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lengrand, J., Pastushenko, I., Vanuytven, S., Song, Y., Venet, D., Sarate, R. M., Bellina, M., Moers, V., Boinet, A., Sifrim, A., Rama, N., Ducarouge, B., Van Herck, J., Dubois, C., Scozzaro, S., Lemaire, S., Gieskes, S., Bonni, S., Collin, A., … Blanpain, C. (2023). Pharmacological targeting of netrin-1 inhibits EMT in cancer. Nature, 620(7973), 402–8. https://doi.org/10.1038/s41586-023-06372-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cassier, P. A., Navaridas, R., Bellina, M., Rama, N., Ducarouge, B., Hernandez-Vargas, H., Delord, J. P., Lengrand, J., Paradisi, A., Fattet, L., Garin, G., Gheit, H., Dalban, C., Pastushenko, I., Neves, D., Jelin, R., Gadot, N., Braissand, N., Leon, S., … Mehlen, P. (2023). Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer. Nature, 620(7973), 409–16. https://doi.org/10.1038/s41586-023-06367-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sung, P. J., Rama, N., Imbach, J., Fiore, S., Ducarouge, B., Neves, D., Chen, H. W., Bernard, D., Yang, P. C., Bernet, A., Depil, S., & Mehlen, P. (2019). Cancer-associated fibroblasts produce netrin-1 to control cancer cell plasticity. Cancer Res, 79(14), 3651–61. https://doi.org/10.1158/0008-5472.CAN-18-2952

Article  CAS  PubMed  Google Scholar 

Xia, X., Mao, Z., Wang, W., Ma, J., Tian, J., Wang, S., & Yin, K. (2023). Netrin-1 promotes the immunosuppressive activity of MDSCs in colorectal cancer. Cancer Immunology Research, 11(5), 600–613. https://doi.org/10.1158/2326-6066.CIR-22-0658

Article  CAS  PubMed  Google Scholar 

Worzfeld, T., & Offermanns, S. (2014). Semaphorins and plexins as therapeutic targets. Nature Reviews. Drug Discovery, 13(8), 603–621. https://doi.org/10.1038/nrd4337

Article  CAS  PubMed  Google Scholar 

Tseng, C. H., Murray, K. D., Jou, M. F., Hsu, S. M., Cheng, H. J., & Huang, P. H. (2011). Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer. PLoS One, 6(4), e19396. https://doi.org/10.1371/journal.pone.0019396

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakraborty, G., Kumar, S., Mishra, R., Patil, T. V., & Kundu, G. C. (2012). Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. PLoS One, 7(3), e33633. https://doi.org/10.1371/journal.pone.0033633

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnkob, M. B., Michaels, Y. S., Andre, V., Macklin, P. S., Gileadi, U., Valvo, S., Rei, M., Kulicke, C., Chen, J. L., Jain, V., Woodcock, V. K., Colin-York, H., Hadjinicolaou, A. V., Kong, Y., Mayya, V., Mazet, J. M., Mead, G. J., Bull, J. A., Rijal, P., … Cerundolo, V. (2024). Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8(+) T cells. Nat Commun., 15(1), 3448. https://doi.org/10.1038/s41467-024-47775-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tominaga, K., Minato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E. I., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K. I., … Gotoh, N. (2019). Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. Proc Natl Acad Sci U S A, 116(2), 625–30. https://doi.org/10.1073/pnas.1806851116

Article  CAS  PubMed  Google Scholar 

Fattet, L., Jung, H. Y., Matsumoto, M. W., Aubol, B. E., Kumar, A., Adams, J. A., Chen, A. C., Sah, R. L., Engler, A. J., Pasquale, E. B., & Yang, J. (2020). Matrix rigidity controls epithelial-mesenchymal plasticity and tumor metastasis via a mechanoresponsive EPHA2/LYN complex. Dev Cell, 54(3), 302–16.e7. https://doi.org/10.1016/j.devcel.2020.05.031

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, P. C., Chen, S. T., Kuo, T. C., Lin, T. C., Lin, M. C., Huang, J., Hung, J. S., Hsu, C. L., Juan, H. F., Lee, P. H., & Huang, M. C. (2020). C1GALT1 is associated with poor survival and promotes soluble ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene, 39(13), 2724–40. https://doi.org/10.1038/s41388-020-1178-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takasugi, M., Okada, R., Takahashi, A., Virya Chen, D., Watanabe, S., & Hara, E. (2017). Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. Nat Commun, 8, 15729. https://doi.org/10.1038/ncomms15728

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao, Z., Han, X., Zhu, Y., Zhang, H., Tian, R., Wang, Z., Cui, Y., Wang, Z., Niu, R., & Zhang, F. (2021). Drug-resistant cancer cell-derived exosomal EphA2 promotes breast cancer metastasis via the EphA2-Ephrin A1 reverse signaling. Cell Death Dis, 12(5), 414. https://doi.org/10.1038/s41419-021-03692-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oudin, M. J., Jonas, O., Kosciuk, T., Broye, L. C., Guido, B. C., Wyckoff, J., Riquelme, D., Lamar, J. M., Asokan, S. B., Whittaker, C., Ma, D., Langer, R., Cima, M. J., Wisinski, K. B., Hynes, R. O., Lauffenburger, D. A., Keely, P. J., Bear, J. E., & Gertler, F. B. (2016). Tumor cell-driven extracellular matrix remodeling drives haptotaxis during metastatic progression. Cancer Discov, 6(5), 516–31. https://doi.org/10.1158/2159-8290.CD-15-1183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes, S. K., Oudin, M. J., Tadros, J., Neil, J., Del Rosario, A., Joughin, B. A., Ritsma, L., Wyckoff, J., Vasile, E., Eddy, R., Philippar, U., Lussiez, A., Condeelis, J. S., van Rheenen, J., White, F., Lauffenburger, D. A., & Gertler, F. B. (2015). PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Mol Biol Cell, 26(21), 3867–78. https://doi.org/10.1091/mbc.E15-06-0442

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oudin, M. J., Barbier, L., Schafer, C., Kosciuk, T., Miller, M. A., Han, S., Jonas, O., Lauffenburger, D. A., & Gertler, F. B. (2017). MENA confers resistance

Comments (0)

No login
gif