Emanuel, N.M. and Obukhova, L.K., Types of experimental delay in aging patterns, Exp. Gerontol., 1978, vol. 13, nos. 1–2, pp. 25–29. https://doi.org/10.1016/0531-5565(78)90026-8
Article CAS PubMed Google Scholar
Nakaidze, N.Sh., Obukhova, L.K., Smirnov, L.D., and Akif’ev, A.P., Influence of the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride on the lifetime of Drosophila melanogaster, Biol. Bull. Acad. Sci. USSR, 1978, vol. 5, no. 4, pp. 505–508.
Obukhova, L.K. and Emanuel, N.M., The role of free-radical oxidation reactions in the molecular mechanisms of the ageing of living organisms, Russ. Chem. Rev., 1983, vol. 52, no. 3, pp. 353–372. https://doi.org/10.1070/RC1983v052n03ABEH002809
Bulterijs, S., Metformin as a geroprotector, Rejuvenation Res., 2011, vol. 14, no. 5, pp. 469–482. https://doi.org/10.1089/rej.2011.1153
Article CAS PubMed Google Scholar
Moskalev, A., Chernyagina, E., Kudryavtseva, A., and Shaposhnikov, M., Geroprotectors: A unified concept and screening approaches, Aging Dis., 2017, vol. 8, no. 3, рр. 354–363. https://doi.org/10.14336/AD.2016.1022
Trendelenburg, A.U., Scheuren, A.C., Potter, P., Müller, R., and Bellantuono, I., Geroprotectors: A role in the treatment of frailty, Mech. Ageing Dev., 2019, vol. 180, pp. 11–20. https://doi.org/10.1016/j.mad.2019.03.002
Article CAS PubMed Google Scholar
Morsli, S. and Bellantuono, I., The use of geroprotectors to prevent multimorbidity: Opportunities and challenges, Mech. Ageing Dev., 2021, vol. 193, p. 111391. https://doi.org/10.1016/j.mad.2020.111391
Article CAS PubMed Google Scholar
Vaiserman, A.M., Life extension by anti-aging drugs: Hormetic explanation, Am. J. Pharmacol. Toxicol., 2008, vol. 3, no. 1, pp. 14–18.
Khokhlov, A.N., Does aging need its own program or is the program of development quite sufficient for it? Stationary cell cultures as a tool to search for anti-aging factors, Curr. Aging Sci., 2013, vol. 6, no. 1, pp. 14–20.
Article CAS PubMed Google Scholar
Khokhlov, A.N., Cell kinetic approaches to the search for anti-aging drugs: Thirty years after, Moscow Univ. Biol. Sci. Bull., 2018, vol. 73, no. 4, pp. 185–190. https://doi.org/10.3103/S0096392518040041
Khokhlov, A.N., Klebanov, A.A., and Morgunova, G.V., Anti-aging drug discovery in experimental gerontological studies: From organism to cell and back, in Aging: Exploring a Complex Phenomenon, Ahmad, Sh.I., Ed., Boca Raton: Taylor and Francis, 2018, pp. 577–595.
Khokhlov, A.N., Reflections of a pessimistic gerontologist or why we still do not live 1000 years, Moscow Univ. Biol. Sci. Bull., 2021, vol. 76, no. 4, pp. 239–243. https://doi.org/10.3103/S0096392521040040
Khokhlov, A.N., Basics of biology of aging for MSU non-biologists, Moscow Univ. Biol. Sci. Bull., 2023, vol. 78, no. 2, pp. 115–120. https://doi.org/10.3103/S0096392523020025
Khokhlov, A.N., Gerontology in the 21st century: From failures to advances. Hopefully, Adv. Gerontol., 2023, vol. 13, no. 1, pp. 1–3. https://doi.org/10.1134/S2079057024600289
Khokhlov, A.N., Klebanov, A.A., and Morgunova, G.V., On choosing control objects in experimental gerontological research, Moscow Univ. Biol. Sci. Bull., 2018, vol. 73, no. 2, pp. 59–62. https://doi.org/10.3103/S0096392518020049
McCay, C.M., Crowell, M.F., Maynard, L.A., The effect of retarded growth upon the length of life span and upon the ultimate body size, J. Nutr., 1935, vol. 10, no. 1, pp. 63–79. https://doi.org/10.1093/jn/10.1.63
McCay, C.M., Pope, F., and Lunsford, W., Experimental prolongation of the life span, Bull. N. Y. Acad. Med., 1956, vol. 32, no. 2, pp. 91–101.
CAS PubMed PubMed Central Google Scholar
Dubina, T.L. and Razumovich, A.N., Vvedenie v eksperimental’nuyu gerontologiyu (Introduction to Experimental Gerontology), Minsk: Nauka Tekh., 1975.
Zimmerman, J.A., Malloy, V., Krajcik, R., and Orentreich, N., Nutritional control of aging, Exp. Gerontol. 2003, vol. 38, nos. 1–2, pp. 47–52. https://doi.org/10.1016/S0531-5565(02)00149-3
Article CAS PubMed Google Scholar
Morgunova, G.V., Not just caloric restriction: A complex approach to prolong lifespan and improve quality of life, Cent. Asian J. Med. Hypotheses Ethics, 2021, vol. 2, no. 4, pp. 190–197. https://doi.org/10.47316/cajmhe.2021.2.4.02
Spiridonova, O., Kriukov, D., Nemirovich-Danchenko, N., and Peshkin, L., On standardization of controls in lifespan studies, Aging (Albany NY), 2024, vol. 16, no. 4, pp. 3047–3055. https://doi.org/10.18632/aging.205604
Article PubMed PubMed Central Google Scholar
Khokhlov, A.N., From Carrel to Hayflick and back, or what we got from the 100-year cytogerontological studies, Biophysics, 2010, vol. 55, no. 5, pp. 859–864. https://doi.org/10.1134/S0006350910050313
Khokhlov, A.N., Why freshwater hydra does not get Alzheimer’s disease, Moscow Univ. Biol. Sci. Bull., 2023, vol. 78, no. 3, pp. 198–204. https://doi.org/10.3103/S0096392523700104
Xu, M., Pirtskhalava, T., Farr, J.N., et al., Senolytics improve physical function and increase lifespan in old age, Nat. Med., 2018, vol. 24, no. 8, pp. 1246–1256. https://doi.org/10.1038/s41591-018-0092-9
Article CAS PubMed PubMed Central Google Scholar
Song, S., Tchkonia, T., Jiang, J., Kirkland, J.L., and Sun, Y., Targeting senescent cells for a healthier aging: challenges and opportunities, Adv. Sci., 2020, vol. 7, no. 23, p. 2002611. https://doi.org/10.1002/advs.202002611
Morgunova, G.V. and Khokhlov, A.N., Drugs with senolytic activity: Prospects and possible limitations, Moscow Univ. Biol. Sci. Bull., 2023, vol. 78, no. 4, pp. 268–273. https://doi.org/10.3103/S0096392524600455
Zhu, Y.I., Tchkonia, T., Pirtskhalava, T., et al., The Achilles’ heel of senescent cells: From transcriptome to senolytic drugs, Aging Cell, 2015, vol. 14, no. 4, pp. 644–658. https://doi.org/10.1111/acel.12344
Article CAS PubMed PubMed Central Google Scholar
Chaib, S., Tchkonia, T., and Kirkland, J.L., Cellular senescence and senolytics: The path to the clinic. Nat. Med., 2022, vol. 28, no. 8, pp. 1556–1568. https://doi.org/10.1038/s41591-022-01923-y
Article CAS PubMed PubMed Central Google Scholar
Stambler, I., Reductionism and holism in the history of aging and longevity research: Does the whole have parts? Part 1. The building of reductionism, Adv. Gerontol., 2023, vol. 13, no. 1, pp. 4–8. https://doi.org/10.1134/S2079057024600022
Stambler, I., Reductionism and holism in the history of aging and longevity research: Does the whole have parts? Part 2. The upwelling of holism. Adv. Gerontol., 2023, vol. 13, no. 2, pp. 45–53. https://doi.org/10.1134/S2079057024600034
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