This work has been funded by the Vagelos Scholars Program in the Molecular Life Sciences grant at the University of Pennsylvania, the Frances Velay Fellowship by the Panaphil and Uphill Foundations and the NIGMS R01-GM138908 grant to R. M. Kohli at the Perelman School of Medicine. The author thanks R. M. Kohli for his mentorship and Kohli laboratory members for their support and motivation.