Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492

Article  PubMed  Google Scholar 

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660

Article  PubMed  Google Scholar 

Lüönd, F., Sugiyama, N., Bill, R., Bornes, L., Hager, C., Tang, F., Santacroce, N., Beisel, C., Ivanek, R., Burglin, T., Tiede, S., Rheenen, J. V., & Christofori, G. (2021). Distinct contributions of partial and full EMT to breast cancer malignancy. Developmental Cell, 56(23), 3203–3221.e11. https://doi.org/10.1016/j.devcel.2021.11.006

Article  PubMed  CAS  Google Scholar 

Tsang, J. Y. S., & Tse, G. M. (2020). Molecular classification of breast cancer. Advances in Anatomic Pathology, 27(1), 27–35. https://doi.org/10.1097/PAP.0000000000000232

Article  PubMed  CAS  Google Scholar 

Butz, H., & Patócs, A. (2022). Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression. Cancer Metastasis Reviews, 41(4), 803–832. https://doi.org/10.1007/s10555-022-10047-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gupta, P. B., Pastushenko, I., Skibinski, A., Blanpain, C., & Kuperwasser, C. (2019). Phenotypic plasticity: Driver of cancer initiation, progression, and therapy resistance. Cell Stem Cell, 24(1), 65–78. https://doi.org/10.1016/j.stem.2018.11.011

Article  PubMed  CAS  Google Scholar 

Lofterød, T., Frydenberg, H., Flote, V., Eggen, A. E., McTiernan, A., Mortensen, E. S., Akslen, A. L., Reitan, J. B., Wilsgaard, T., & Thune, I. (2020). Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: The EBBA-Life study. Breast Cancer Research and Treatment, 182(1), 215–227. https://doi.org/10.1007/s10549-020-05679-2

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fischer, A., Ziogas, A., & Anton-Culver, H. (2018). Perception matters: Stressful life events increase breast cancer risk. Journal of Psychosomatic Research, 110, 46–53. https://doi.org/10.1016/j.jpsychores.2018.03.010

Article  PubMed  PubMed Central  Google Scholar 

Ramírez-Expósito, M. J., Dueñas-Rodríguez, B., Carrera-González, M. P., Navarro-Cecilia, J., & Martínez-Martos, J. M. (2021). Circulating levels of β-endorphin and cortisol in breast cancer. Comprehensive Psychoneuroendocrinology, 5, 100028. https://doi.org/10.1016/j.cpnec.2021.100028

Article  PubMed  PubMed Central  Google Scholar 

Mitre-Aguilar, I. B., Moreno-Mitre, D., Melendez-Zajgla, J., Maldonado, V., Jacobo-Herrera, N. J., Ramirez-Gonzalez, V., & Mendoza-Almanza, G. (2022). The Role of glucocorticoids in breast cancer therapy. Current Oncology (Toronto, Ont.), 30(1), 298–314. https://doi.org/10.3390/curroncol30010024

Article  PubMed  Google Scholar 

Alyusuf, R., Wazir, J. F., Brahmi, U. P., Fakhro, A. R., & Bakhiet, M. (2017). The immunoexpression of glucocorticoid receptors in breast carcinomas, lactational change, and normal breast epithelium and its possible role in mammary carcinogenesis. International Journal of Breast Cancer, 2017, 1403054. https://doi.org/10.1155/2017/1403054

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pan, D., Kocherginsky, M., & Conzen, S. D. (2011). Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Research, 71(20), 6360–6370. https://doi.org/10.1158/0008-5472.CAN-11-0362

Article  PubMed  PubMed Central  CAS  Google Scholar 

Skor, M. N., Wonder, E. L., Kocherginsky, M., Goyal, A., Hall, B. A., Cai, Y., & Conzen, S. D. (2013). Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 19(22), 6163–6172. https://doi.org/10.1158/1078-0432.CCR-12-3826

Article  PubMed  CAS  Google Scholar 

Kach, J., Conzen, S. D., & Szmulewitz, R. Z. (2015). Targeting the glucocorticoid receptor in breast and prostate cancers. Science Translational Medicine, 7(305), 305ps19. https://doi.org/10.1126/scitranslmed.aac7531

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mourtzi, N., Sertedaki, A., & Charmandari, E. (2021). Glucocorticoid signaling and epigenetic alterations in stress-related disorders. International Journal of Molecular Sciences, 22(11), 5964. https://doi.org/10.3390/ijms22115964

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vettorazzi, S., Nalbantoglu, D., Gebhardt, J. C. M., & Tuckermann, J. (2022). A guide to changing paradigms of glucocorticoid receptor function-A model system for genome regulation and physiology. The FEBS Journal, 289(19), 5718–5743. https://doi.org/10.1111/febs.16100

Article  PubMed  CAS  Google Scholar 

Noureddine, L. M., Trédan, O., Hussein, N., Badran, B., Le Romancer, M., & Poulard, C. (2021). Glucocorticoid receptor: A multifaceted actor in breast cancer. International Journal of Molecular Sciences, 22(9), 4446. https://doi.org/10.3390/ijms22094446

Article  PubMed  PubMed Central  CAS  Google Scholar 

Truong, T. H., & Lange, C. A. (2018). Deciphering steroid receptor crosstalk in hormone-driven cancers. Endocrinology, 159(12), 3897–3907. https://doi.org/10.1210/en.2018-00831

Article  PubMed  PubMed Central  CAS  Google Scholar 

West, D. C., Pan, D., Tonsing-Carter, E. Y., Hernandez, K. M., Pierce, C. F., Styke, S. C., Bowie, K. R., Garcia, T. I., Kocherginsky, M., & Conzen, S. D. (2016). GR and ER Coactivation alters the expression of differentiation genes and associates with improved ER+ breast cancer outcome. Molecular cancer research: MCR, 14(8), 707–719. https://doi.org/10.1158/1541-7786.MCR-15-0433

Article  PubMed  CAS  Google Scholar 

Cardoso, F., Costa, A., Senkus, E., Aapro, M., André, F., Barrios, C. H., Bergh, J., Bhattacharyya, G., Biganzoli, L., Cardoso, M. J., Carey, L., Corneliussen-James, D., Curigliano, G., Dieras, V., El Saghir, N., Eniu, A., Fallowfield, L., Fenech, D., Francis, P., et al. (2017). 3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3). Annals of Oncology: Official Journal of the European Society for Medical Oncology, 28(1), 16–33. https://doi.org/10.1093/annonc/mdw544

Article  PubMed  CAS  Google Scholar 

Nelson, D. R., Brown, J., Morikawa, A., & Method, M. (2022). Breast cancer-specific mortality in early breast cancer as defined by high-risk clinical and pathologic characteristics. PLoS One, 17(2), e0264637. https://doi.org/10.1371/journal.pone.0264637

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhidkova, E. M., Lylova, E. S., Savinkova, A. V., Mertsalov, S. A., Kirsanov, K. I., Belitsky, G. A., Yakubovskaya, M. G., & Lesovaya, E. A. (2020). A brief overview of the paradoxical role of glucocorticoids in breast cancer. Breast Cancer: Basic and Clinical Research, 14, 1178223420974667. https://doi.org/10.1177/1178223420974667

Article  PubMed  Google Scholar 

Kong, D., Hughes, C. J., & Ford, H. L. (2020). Cellular plasticity in breast cancer progression and therapy. Frontiers in Molecular Biosciences, 7, 72. https://doi.org/10.3389/fmolb.2020.00072

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pan, H., Gray, R., Braybrooke, J., Davies, C., Taylor, C., McGale, P., Peto, R., Pritchard, K. I., Bergh, J., Dowsett, M., & Hayes, D. F. (2017). 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years. The New England Journal of Medicine, 377(19), 1836–1846. https://doi.org/10.1056/NEJMoa1701830

Article  PubMed  PubMed Central  Google Scholar 

Bushnell, G. G., Deshmukh, A. P., den Hollander, P., Luo, M., Soundararajan, R., Jia, D., Levine, H., Mani, S. A., & Wicha, M. S. (2021). Breast cancer dormancy: Need for clinically relevant models to address current gaps in knowledge. NPJ breast cancer, 7(1), 66. https://doi.org/10.1038/s41523-021-00269-x

Article  PubMed  PubMed Central  Google Scholar 

Yang, X., Liang, X., Zheng, M., & Tang, Y. (2018). Cellular phenotype plasticity in cancer dormancy and metastasis. Frontiers in Oncology, 8, 505. https://doi.org/10.3389/fonc.2018.00505

Article  PubMed  PubMed Central  Google Scholar 

Aouad, P., Zhang, Y., De Martino, F., Stibolt, C., Ali, S., Ambrosini, G., Mani, S. A., Maggs, K., Quinn, H. M., Sflomos, G., & Brisken, C. (2022). Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nature Communications, 13(1), 4975. https://doi.org/10.1038/s41467-022-32523-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qin, X., Li, T., Li, S., Yang, H., Wu, C., Zheng, C., You, F., & Liu, Y. (2020). The tumor biochemical and biophysical microenvironments synergistically contribute to cancer cell malignancy. Cellular & Molecular Immunology, 17(11), 1186–1187. https://doi.org/10.1038/s41423-019-0282-5

Article  CAS  Google Scholar 

Dirkse, A., Golebiewska, A., Buder, T., Nazarov, P. V., Muller, A., Poovathingal, S., Brons, N. H. C., Leite, S., Sauvageot, N., Sarkisjan, D., Seyfrid, M., Fritah, S., Stieber, D., Michelucci, A., Hertel, F., Herold-Mende, C., Azuaje, F., Skupin, A., Bjerkvig, R., et al. (2019). Stem cell-associated heterogeneity in glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. Nature Communications, 10(1), 1787. https://doi.org/10.1038/s41467-019-09853-z

Article  PubMed  PubMed Central  CAS 

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