Lack of Skeletal Muscle Serotonin Impairs Physical Performance

1. Walther, DJ, Peter, J, Bashammakh, S. Synthesis of serotonin by a second. Science. 2003;299:76.
Google Scholar | Crossref | Medline | ISI2. Côté, F, Thévenot, E, Fligny, C, et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci U S A. 2003;100:13525-13530.
Google Scholar | Crossref | Medline3. Cervenka, I, Agudelo, LZ, Ruas, JL. Kynurenines: tryptophan’s metabolites in exercise, inflammation, and mental health. Science. 2017;357:369:eaaf9794.
Google Scholar | Crossref4. Platten, M, Wick, W, Van Den Eynde, BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res. 2012;72:5435-5440.
Google Scholar | Crossref | Medline | ISI5. Oxenkrug, GF. Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan – kynurenine metabolism. Ann N Y Acad Sci. 2010;1199:1-14.
Google Scholar | Crossref | Medline | ISI6. Georgin-Lavialle, S, Gaillard, R, Moura, D, Hermine, O. Mastocytosis in adulthood and neuropsychiatric disorders. Transl Res. 2016;174:77-85.
Google Scholar | Crossref | Medline7. Sibon, D, Coman, T, Rossignol, J, Fontenay, M, Hermine, O, Francine, C, et al. Enhanced renewal of erythroid progenitors in myelodysplastic anemia by peripheral serotonin. Cell Rep. 2019;26:3246-3256.
Google Scholar | Crossref | Medline8. Soares, J, Naffah-Mazzacoratti, MG, Cavalheiro, EA. Increased serotonin levels in physically trained men. Braz J Med Biol Res. 1994;27:1635-1638.
Google Scholar | Medline9. Wegner, M, Helmich, I, Machado, S, Nardi, A, Arias-Carrion, O, Budde, H. Effects of exercise on anxiety and depression disorders: review of meta-analyses and neurobiological mechanisms. CNS Neurol Disord Drug Targets. 2014;13:1002-1014.
Google Scholar | Crossref | Medline | ISI10. Schlittler, M, Goiny, M, Agudelo, LZ, et al. Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans. Am J Physiol Cell Physiol. 2016;310:C836-C840.
Google Scholar | Crossref | Medline | ISI11. Lewis, GD, Farrell, L, Wood, MJ, et al. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010;2:33ra37.
Google Scholar | Crossref12. Agudelo, LZ, Femenía, T, Orhan, F, et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell. 2014;159:33-45.
Google Scholar | Crossref | Medline | ISI13. Barton, DA, Esler, MD, Dawood, T, et al. Elevated brain serotonin turnover in patients with depression. Arch Gen Psychiatry. 2008;65:38.
Google Scholar | Crossref | Medline14. Calapai, G, Corica, F, Corsonello, A, et al. Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. J Clin Invest. 1999;104:975-982.
Google Scholar | Crossref | Medline15. Cotman, CW, Berchtold, NC, Christie, L-A. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30:464-472.
Google Scholar | Crossref | Medline | ISI16. Mattson, MP. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab. 2012;16:706-722.
Google Scholar | Crossref | Medline | ISI17. Fligny, C, Fromes, Y, Bonnin, P, et al. Maternal serotonin influences cardiac function in adult offspring. FASEB J. 2008;22:2340-2349.
Google Scholar | Crossref | Medline18. Suidan, GL, Duerschmied, D, Dillon, GM, et al. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PLoS One. 2013;8:e59032.
Google Scholar | Crossref | Medline19. Hausdorff, JM, Mitchell, SL, Firtion, R, et al. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington’s disease. J Appl Physiol. 1997;82:262-269.
Google Scholar | Crossref | Medline20. Jouffroy, R, Alves, B, Mauvieux, B, Mallet, L, Beaudeux, J-L, Cottart, C-H. NSE & S100B protein blood level assessment during a long-distance trail race. Ann Biol Clin (Paris). 2019;77:532-536.
Google Scholar | Medline21. Thomasson, R, Vignier, N, Peccate, C, Mougenot, N, Noirez, P, Muchir, A. Alteration of performance in a mouse model of Emery-Dreifuss muscular dystrophy caused by A-type lamins gene mutation. Hum Mol Genet. 2019;28:2237-2244.
Google Scholar | Crossref | Medline22. de Loor, H, Poesen, R, De Leger, W, et al. A liquid chromatography – tandem mass spectrometry method to measure a selected panel of uremic retention solutes derived from endogenous and colonic microbial metabolism. Anal Chim Acta. 2016;936:149-156.
Google Scholar | Crossref | Medline23. Boulet, L, Faure, P, Flore, P, Montérémal, J, Ducros, V. Simultaneous determination of tryptophan and 8 metabolites in human plasma by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci [Internet]. 2017;1054:36-43.
Google Scholar | Crossref | Medline

Comments (0)

No login
gif