Pregnancy outcome following radioactive iodine therapy for Graves’ disease in women of childbearing age: a systematic review

De Leo S, Lee SY, Braverman LE. Hyperthyroidism Lancet. 2016;388(10047):906–18.

Article  PubMed  Google Scholar 

Doubleday AR, Sippel RS, Hyperthyroidism. Gland Surg. 2020;9(1):124–35.

Article  PubMed  PubMed Central  Google Scholar 

Mohan V, Lind R. A review of treatment options for Graves’ disease: why total thyroidectomy is a viable option in selected patients. J Community Hosp Intern Med Perspect. 2016;6(4):32369.

Article  PubMed  Google Scholar 

Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, et al. 2016 American thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26(10):1343–421.

Article  PubMed  Google Scholar 

Yaish I, Azem F, Gutfeld O, Silman Z, Serebro M, Sharon O, et al. A single radioactive iodine treatment has a deleterious effect on ovarian reserve in women with thyroid cancer: results of a prospective pilot study. Thyroid. 2018;28(4):522–7.

Article  CAS  PubMed  Google Scholar 

Piek MW, Postma EL, Van Leeuwaarde R, De Boer JP, Bos AME, Lok C, et al. The effect of radioactive iodine therapy on ovarian function and fertility in female thyroid Cancer patients: A systematic review and Meta-Analysis. Thyroid. 2021;31(4):658–68.

Article  CAS  PubMed  Google Scholar 

Leövey A, Kálmán K, Bakó G, Szabó T. The significance of thyroid-stimulating antibody (TSAb) in the management and prognostic evaluation of Graves disease. Acta Med Hung. 1985;42(1–2):3–11.

PubMed  Google Scholar 

Read CH Jr., Tansey MJ, Menda Y. A 36-year retrospective analysis of the efficacy and safety of radioactive iodine in treating young Graves’ patients. J Clin Endocrinol Metab. 2004;89(9):4229–33.

Article  CAS  PubMed  Google Scholar 

Safa AM, Schumacher OP, Rodriguez-Antunez A. Long-term follow-up results in children and adolescents treated with radioactive iodine (131I) for hyperthyroidism. N Engl J Med. 1975;292(4):167–71.

Article  CAS  PubMed  Google Scholar 

Guan L, Chen G, Zhang J, Wang L. The preliminary clinical observation and analysis of childbearingage women with a history of iodine-131 treatment for Graves’ disease. Biosci Trends. 2016;10(4):307–14.

Article  CAS  PubMed  Google Scholar 

Zeng J, Wang J, Guo Q, Hou Y, Lei Q, Yao B, et al. Effects of maternal exposure to 131I used for treatment of Graves’ disease during childbearing age on chromosomal aberration and intellectual development of offspring. Int J Radiation Res. 2022;20(4):785–91.

Google Scholar 

Zhang LH, Li JY, Tian Q, Liu S, Zhang H, Liu S, et al. Follow-up and evaluation of the pregnancy outcome in women of reproductive age with Graves’ disease after 131Iodine treatment. J Radiat Res. 2016;57(6):702–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamada N, Momotani N, Ishikawa N, Noh JY, Okamoto Y, Konishi T, et al. Persistent high trab values during pregnancy predict increased risk of neonatal hyperthyroidism following radioiodine therapy for refractory hyperthyroidism. Endocr J. 2011;58(1):55–8.

Article  PubMed  Google Scholar 

Yoshihara A, Iwaku K, Noh JY, Watanabe N, Kunii Y, Ohye H, et al. Incidence of neonatal hyperthyroidism among newborns of Graves’ disease patients treated with radioiodine therapy. Thyroid. 2019;29(1):128–34.

Article  CAS  PubMed  Google Scholar 

Yoshihara A, Noh JY, Watanabe N, Iwaku K, Kobayashi S, Suzuki M, et al. Lower incidence of postpartum thyrotoxicosis in women with Graves disease treated by radioiodine therapy than by subtotal thyroidectomy or with antithyroid drugs. Clin Nucl Med. 2014;39(4):326–9.

Article  PubMed  Google Scholar 

Elston MS, Tu’akoi K, Meyer-Rochow GY, Tamatea JA, Conaglen JV. Pregnancy after definitive treatment for Graves’ disease–does treatment choice influence outcome? Aust N Z J Obstet Gynaecol. 2014;54(4):317–21.

Article  PubMed  Google Scholar 

Männistö T, Mendola P, Grewal J, Xie Y, Chen Z, Laughon SK. Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort. J Clin Endocrinol Metabolism. 2013;98(7):2725–33.

Article  Google Scholar 

Aggarawal N, Suri V, Singla R, Chopra S, Sikka P, Shah VN, et al. Pregnancy outcome in hyperthyroidism: A case control study. Gynecol Obstet Invest. 2014;77(2):94–9.

Article  PubMed  Google Scholar 

Xu Y, Li C, Wang W, Yu X, Liu A, Shi Y, et al. Gestational and postpartum complications in patients with first trimester thyrotoxicosis: A prospective multicenter cohort study from Northeast China. Thyroid. 2023;33(6):762–70.

Article  CAS  PubMed  Google Scholar 

Pendina AA, Krapivin MI, Chiryaeva OG, Petrova LI, Pashkova EP, Golubeva AV, et al. Chromosomal abnormalities in miscarriages and maternal age: new insights from the study of 7118 cases. Cells. 2024;14(1):8.

Article  PubMed  PubMed Central  Google Scholar 

Grande M, Borrell A, Garcia-Posada R, Borobio V, Munoz M, Creus M, et al. The effect of maternal age on chromosomal anomaly rate and spectrum in recurrent miscarriage. Hum Reprod. 2012;27(10):3109–17.

Article  PubMed  Google Scholar 

Ohno M, Maeda T, Matsunobu A. A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi. Obstet Gynecol. 1991;77(3):394–8.

CAS  PubMed  Google Scholar 

Magnus MC, Wilcox AJ, Morken NH, Weinberg CR, Håberg SE. Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. BMJ. 2019;364:l869.

Article  PubMed  PubMed Central  Google Scholar 

Andersen AMN. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320(7251):1708–12.

Article  PubMed Central  Google Scholar 

Berman M, Burke LBJ, De Groot L, McCormack K, Oddie T, et al. Summary of current radiation dose estimates to humans from 123I, 124I, 125I, 126I, 130I, 131I, and 132I as sodium iodide. J Nucl Med. 1975;16(9):857–60.

Google Scholar 

Stabin MG, Watson EE, Marcus CS, Salk RD. Radiation dosimetry for the adult female and fetus from iodine-131 administration in hyperthyroidism. J Nucl Med. 1991;32(5):808–13.

CAS  PubMed  Google Scholar 

Briere J, Philippon B. Absorbed dose to ovaries or uterus during a 131I-therapeutic of cancer or hyperthyroidism: comparison between in vivo measurements by TLD and calculations. Int J Appl Radiat Isot. 1979;30(10):643–6.

Article  CAS  PubMed  Google Scholar 

Robertson JS, Gorman CA. Gonadal radiation dose and its genetic significance in radioiodine therapy of hyperthyroidism. J Nucl Med. 1976;17(9):826–35.

CAS  PubMed  Google Scholar 

Laurberg P, Wallin G, Tallstedt L, Abraham-Nordling M, Lundell G, Tørring O. TSH-receptor autoimmunity in Graves’ disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. Eur J Endocrinol. 2008;158(1):69–75.

Article  CAS  PubMed  Google Scholar 

Chiappori A, Villalta D, Bossert I, Ceresola EM, Lanaro D, Schiavo M, et al. Thyrotropin receptor autoantibody measurement following radiometabolic treatment of hyperthyroidism: comparison between different methods. J Endocrinol Investig. 2010;33(3):197–201.

Article  CAS  Google Scholar 

Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid. 1999;9(7):727–33.

Article  CAS  PubMed  Google Scholar 

Zakarija M, McKenzie JM. Pregnancy-Associated changes in the Thyroid-Stimulating antibody of Graves’ disease and the relationship to neonatal hyperthyroidism. J Clin Endocrinol Metabolism. 1983;57(5):1036–40.

Article  CAS  Google Scholar 

De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, et al. Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline. J Clin Endocrinol Metabolism. 2012;97(8):2543–65.

Article  Google Scholar 

Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27(3):315–89.

Article  PubMed 

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