(-)-Epicatechin regulates the resistance of lung adenocarcinoma cells to radiotherapy through the downregulation of FOXM1

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756–760. https://doi.org/10.1038/nature05236

Article  CAS  PubMed  Google Scholar 

Blazek ER, Foutch JL, Maki G (2007) Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia. Int J Radiation Oncol, Biol, Phys 67:1–5. https://doi.org/10.1016/j.ijrobp.2006.09.037

Article  CAS  Google Scholar 

Cao J, Li J, Sun L, Qin T, Xiao Y, Chen K, Qian W, Duan W, Lei J, Ma J, Ma Q, Han L (2019) Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1. Mol Oncol 13:228–245. https://doi.org/10.1002/1878-0261.12399

Article  CAS  PubMed  Google Scholar 

Cho YM, Kim YS, Kang MJ, Farrar WL, Hurt EM (2012) Long-term recovery of irradiated prostate cancer increases cancer stem cells. The Prostate 72:1746–1756. https://doi.org/10.1002/pros.22527

Article  PubMed  PubMed Central  Google Scholar 

de Jong MC, Pramana J, van der Wal JE, Lacko M, Peutz-Kootstra CJ, de Jong JM, Takes RP, Kaanders JH, van der Laan BF, Wachters J, Jansen JC, Rasch CR, van Velthuysen ML, Grénman R, Hoebers FJ, Schuuring E, van den Brekel MW, Begg AC (2010) CD44 expression predicts local recurrence after radiotherapy in larynx cancer. Clin Cancer Res: an Off J Am Assoc Cancer Res 16:5329–5338. https://doi.org/10.1158/1078-0432.Ccr-10-0799

Article  Google Scholar 

Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF (2009) Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458:780–783. https://doi.org/10.1038/nature07733

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding M, Zhao J, Bowman L, Lu Y, Shi X (2010) Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin. Int J Oncol 36:59–67

CAS  PubMed  Google Scholar 

Elbaz HA, Lee I, Antwih DA, Liu J, Hüttemann M, Zielske SP (2014) Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation. PloS One 9:e88322. https://doi.org/10.1371/journal.pone.0088322

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glumac PM, LeBeau AM (2018) The role of CD133 in cancer: a concise review. Clin Transl Med 7:1–14

Article  Google Scholar 

Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL, Paz-Ares L (2017) Lung cancer: current therapies and new targeted treatments. Lancet (London, England) 389:299–311.https://doi.org/10.1016/s0140-6736(16)30958-8.

Huang M, Wang J, Zhou H, Lv Z, Li T, Liu M, Lv Y, Wu A, Xia J, Xu H, Chen W, Liu P (2024) (-) - Epicatechin regulates LOC107986454 by targeting the miR-143-3p/EZH2 axis to enhance the radiosensitivity of non-small cell lung cancer. Am J Med Sci. https://doi.org/10.1016/j.amjms.2024.06.02710.1016/j.amjms.2024.06.027

Article  PubMed  Google Scholar 

Juan H, Luyuan W, Bin T, Rongrong R, Taoxiong S, Liwei Z, Jiao D, Chenggang L, Yan W, Qingfu C (2022) Integrated transcriptomics and widely targeted metabolomics analyses provide insights into flavonoid biosynthesis in the rhizomes of golden buckwheat (Fagopyrum cymosum)&#13. Front Plant Sci 13:803472–803472

Article  Google Scholar 

Kalinina OA, Kalinin SA, Polack EW, Mikaelian I, Panda S, Costa RH, Adami GR (2003) Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions. Oncogene 22:6266–6276. https://doi.org/10.1038/sj.onc.1206640

Article  CAS  PubMed  Google Scholar 

Kang MS, Ham YM, Oh DJ, Jung YH, Han SI, Kim JH (2021) Lapathoside A isolated from Fagopyrum esculentum induces apoptosis in human pancreatic cancer cells. Anticancer Res 41:747–756. https://doi.org/10.21873/anticanres.14826

Article  CAS  PubMed  Google Scholar 

Kim IM, Ackerson T, Ramakrishna S, Tretiakova M, Wang IC, Kalin TV, Major ML, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV (2006) The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res 66:2153–2161. https://doi.org/10.1158/0008-5472.Can-05-3003

Article  CAS  PubMed  Google Scholar 

Koo CY, Muir KW, Lam EW (2012) FOXM1: from cancer initiation to progression and treatment. Biochimica et Biophys Acta 1819:28–37. https://doi.org/10.1016/j.bbagrm.2011.09.004

Article  CAS  Google Scholar 

Krisnawan VE, Stanley JA, Schwarz JK, DeNardo DG (2020) Tumor microenvironment as a regulator of radiation therapy: new insights into stromal-mediated radioresistance. Cancers 12(10):2916. https://doi.org/10.3390/cancers12102916

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laoukili J, Kooistra MR, Brás A, Kauw J, Kerkhoven RM, Morrison A, Clevers H, Medema RH (2005) FoxM1 is required for execution of the mitotic programme and chromosome stability. Nature Cell Biol 7:126–136. https://doi.org/10.1038/ncb1217

Article  CAS  PubMed  Google Scholar 

Lee Y, Kim KH, Kim DG, Cho HJ, Kim Y, Rheey J, Shin K, Seo YJ, Choi YS, Lee JI, Lee J, Joo KM, Nam DH (2015) FoxM1 promotes stemness and radio-resistance of glioblastoma by regulating the master stem cell regulator Sox2. PloS One 10:e0137703. https://doi.org/10.1371/journal.pone.0137703

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li F, Zhou K, Gao L, Zhang B, Li W, Yan W, Song X, Yu H, Wang S, Yu N, Jiang Q (2016) Radiation induces the generation of cancer stem cells: a novel mechanism for cancer radioresistance. Oncol Lett 12:3059–3065. https://doi.org/10.3892/ol.2016.5124

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li T, Ma J, Han X, Jia Y, Yuan H, Shui S, Guo D (2018) MicroRNA-320 enhances radiosensitivity of glioma through down-regulation of sirtuin type 1 by directly targeting forkhead box protein M1. Transl Oncol 11:205–212. https://doi.org/10.1016/j.tranon.2017.12.008

Article  PubMed  PubMed Central  Google Scholar 

Liao GB, Li XZ, Zeng S, Liu C, Yang SM, Yang L, Hu CJ, Bai JY (2018) Regulation of the master regulator FOXM1 in cancer. Cell CommunSignaling : CCS 16:57. https://doi.org/10.1186/s12964-018-0266-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu M, Dai B, Kang SH, Ban K, Huang FJ, Lang FF, Aldape KD, Xie TX, Pelloski CE, Xie K, Sawaya R, Huang S (2006) FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66:3593–3602. https://doi.org/10.1158/0008-5472.Can-05-2912

Article  CAS  PubMed  Google Scholar 

Luo H, Vong CT, Chen H, Gao Y, Lyu P, Qiu L, Zhao M, Liu Q, Cheng Z, Zou J, Yao P, Gao C, Wei J, Ung COL, Wang S, Zhong Z, Wang Y (2019) Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine. Chin Med 14:48. https://doi.org/10.1186/s13020-019-0270-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Q, Liu Y, Shang L, Yu J, Qu Q (2017) The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma. Oncol Rep 38:3367–3375. https://doi.org/10.3892/or.2017.6032

Article  CAS  PubMed  PubMed Central  Google Scholar 

Madureira PA, Varshochi R, Constantinidou D, Francis RE, Coombes RC, Yao KM, Lam EW (2006) The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. J Biol Chem 281:25167–25176. https://doi.org/10.1074/jbc.M603906200

Article  CAS  PubMed  Google Scholar 

Moncharmont C, Levy A, Gilormini M, Bertrand G, Chargari C, Alphonse G, Ardail D, Rodriguez-Lafrasse C, Magné N (2012) Targeting a cornerstone of radiation resistance: cancer stem cell. Cancer Lett 322:139–147. https://doi.org/10.1016/j.canlet.2012.03.024

Article  CAS  PubMed  Google Scholar 

Nandi D, Cheema PS, Jaiswal N, Nag A (2018) FoxM1: repurposing an oncogene as a biomarker. Seminars Cancer Biol 52:74–84. https://doi.org/10.1016/j.semcancer.2017.08.009

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