Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N et al (2013) A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 154:1047–1059. https://doi.org/10.1016/j.cell.2013.07.042

Article  CAS  PubMed  Google Scholar 

Basu S, Totty NF, Irwin MS, Sudol M, Downward J (2003) Akt phosphorylates the yes-associated protein, YAP, to induce interaction with 14–3-3 and attenuation of p73-mediated apoptosis. Mol Cell 11:11–23. https://doi.org/10.1016/S1097-2765(02)00776-1

Article  CAS  PubMed  Google Scholar 

Chakraborty S, Njah K, Pobbati AV, Lim YB, Raju A, Lakshmanan M et al (2017) Agrin as a mechanotransduction signal regulating YAP through the hippo pathway. Cell Rep 18:2464–2479. https://doi.org/10.1016/j.celrep.2017.02.041

Article  CAS  PubMed  Google Scholar 

Ciciarello M, Mangiacasale R, Thibier C, Guarguaglini G, Marchetti E, Di Fiore B et al (2004) Importin β is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells. J Cell Sci 117:6511–6522. https://doi.org/10.1242/jcs.01569

Article  CAS  PubMed  Google Scholar 

Cox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD et al (2015) Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Mol Biol Cell 26:2673–2684. https://doi.org/10.1091/mbc.E15-04-0224

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng H, Wang W, Yu J, Zheng Y, Qing Y, Pan D (2015) Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. eLife 4:e06567. https://doi.org/10.7554/eLife.06567

Article  PubMed  PubMed Central  Google Scholar 

Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M et al (2011) Role of YAP/TAZ in mechanotransduction. Nature 474:179–183. https://doi.org/10.1038/nature10137

Article  CAS  PubMed  Google Scholar 

Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ et al (2017) Force triggers YAP nuclear entry by regulating transport across nuclear pores. Cell 171:1397-1410.e14. https://doi.org/10.1016/j.cell.2017.10.008

Article  CAS  PubMed  Google Scholar 

Elosegui-Artola A, Oria R, Chen Y, Kosmalska A, Pérez-González C, Castro N et al (2016) Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol 18:540–548. https://doi.org/10.1038/ncb3336

Article  CAS  PubMed  Google Scholar 

Fang L, Teng H, Wang Y, Liao G, Weng L, Li Y et al (2018) SET1A-mediated mono-methylation at K342 regulates YAP activation by blocking its nuclear export and promotes tumorigenesis. Cancer Cell 34:103-118.e9. https://doi.org/10.1016/j.ccell.2018.06.002

Article  CAS  PubMed  Google Scholar 

Franklin JM, Ghosh RP, Shi Q, Reddick MP, Liphardt JT (2020) Concerted localization-resets precede YAP-dependent transcription. Nat Commun 11:4581. https://doi.org/10.1038/s41467-020-18368-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-García M, Sánchez-Perales S, Jarabo P, Calvo E, Huyton T, Fu L et al (2022) Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. Nat Commun 13:1174. https://doi.org/10.1038/s41467-022-28693-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Görlich D (1998) Transport into and out of the cell nucleus. EMBO J 17:2721–2727. https://doi.org/10.1093/emboj/17.10.2721

Article  PubMed  PubMed Central  Google Scholar 

Görlich D, Panté N, Kutay U, Aebi U, Bischoff FR (1996) Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J 15:5584–5594

Article  PubMed  PubMed Central  Google Scholar 

Harvey KF, Pfleger CM, Hariharan IK (2003) The drosophila Mst Ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114:457–467. https://doi.org/10.1016/S0092-8674(03)00557-9

Article  CAS  PubMed  Google Scholar 

Jensen EC (2013) Quantitative analysis of histological staining and fluorescence using ImageJ. Anat Rec 296:378–381. https://doi.org/10.1002/ar.22641

Article  Google Scholar 

Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M et al (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14–3-3 and PDZ domain proteins. EMBO J 19:6778–6791. https://doi.org/10.1093/emboj/19.24.6778

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keren K, Yam PT, Kinkhabwala A, Mogilner A, Theriot JA (2009) Intracellular fluid flow in rapidly moving cells. Nat Cell Biol 11:1219–1224. https://doi.org/10.1038/ncb1965

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kofler M, Kapus A (2023) Nuclear Import and Export of YAP and TAZ. Cancers 15:4956. https://doi.org/10.3390/cancers15204956

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kolodney MS, Elson EL (1995) Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain. Proc Natl Acad Sci 92:10252–10256. https://doi.org/10.1073/pnas.92.22.10252

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koslover EF, Chan CK, Theriot JA (2017) Cytoplasmic flow and mixing due to deformation of motile cells. Biophys J 113:2077–2087. https://doi.org/10.1016/j.bpj.2017.09.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S, Hahn KM (2000) Localized Rac activation dynamics visualized in living cells. Science 290:333–337. https://doi.org/10.1126/science.290.5490.333

Article  CAS  PubMed  Google Scholar 

Kuhn M (1998) The microtubule depolymerizing drugs nocodazole and colchicine inhibit the uptake of Listeria monocytogenes by P388D1 macrophages. FEMS Microbiol Lett 160:87–90. https://doi.org/10.1111/j.1574-6968.1998.tb12895.x

Article  CAS  PubMed  Google Scholar 

Lee M-J, Byun MR, Furutani-Seiki M, Hong JH, Jung HS (2014) YAP and TAZ regulate skin wound healing. J Invest Dermatol 134:518–525. https://doi.org/10.1038/jid.2013.339

Article  CAS  PubMed  Google Scholar 

Lehman W, Craig R, Vibert P (1994) Ca2+-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction. Nature 368:65–67. https://doi.org/10.1038/368065a0

Article  CAS  PubMed  Google Scholar 

Li H, Liu Y, Zhang J, Cai M, Cao Z, Gao J et al (2022) Quantification of mechanical stimuli inducing nucleoplasmic translocation of YAP and its distribution mechanism using an AFM–dSTORM coupled technique. Nanoscale 14:15516–15524. https://doi.org/10.1039/D2NR03366F

Article  CAS  PubMed  Google Scholar 

Li J, Biel T, Lomada P, Yu Q, Kim T (2017) Buckling-induced F-actin fragmentation modulates the contraction of active cytoskeletal networks. Soft Matter 13:3213–3220. https://doi.org/10.1039/C6SM02703B

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J et al (2010) The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 24:1106–1118.