Francis A, Harhay MN, Ong ACM, Tummalapalli SL, Ortiz A, Fogo AB, Fliser D, Roy-Chaudhury P, Fontana M, Nangaku M, Wanner C, Malik C, Hradsky A, Adu D, Bavanandan S, Cusumano A, Sola L, Ulasi I, Jha V. American society of, A. European renal, N. International society of, chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol. 2024;20(7):473–85.

Article  PubMed  Google Scholar 

Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022;12(1):7–11.

Article  PubMed  Google Scholar 

Gewin LS. Sugar or fat?? Renal tubular metabolism reviewed in health and disease. Nutrients 13(5) (2021).

Lee DY, Kim JY, Ahn E, Hyeon JS, Kim GH, Park KJ, Jung Y, Lee YJ, Son MK, Kim SW, Han SY, Kim JH, Roh GS, Cha DR, Hwang GS, Kim WH. Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease. Transl Res. 2022;249:88–109.

Article  CAS  PubMed  Google Scholar 

Dhawan S, Musa AH, Mantripragada K. Novel mitochondrial cytopathy causing mitochondrial encephalomyopathy with lactic acidosis and Stroke-Like episodes syndrome and tubulointerstitial nephropathy. Cureus. 2024;16(8):e66722.

PubMed  PubMed Central  Google Scholar 

Curthoys NP, Moe OW. Proximal tubule function and response to acidosis. Clin J Am Soc Nephrol. 2014;9(9):1627–38.

Article  CAS  PubMed  Google Scholar 

Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na(+)/H(+) exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013;91(8):951–63.

Article  PubMed  Google Scholar 

Schnaper HW. The tubulointerstitial pathophysiology of progressive kidney disease. Adv Chronic Kidney Dis. 2017;24(2):107–16.

Article  PubMed  PubMed Central  Google Scholar 

Kuhn C, Mohebbi N, Ritter A. Metabolic acidosis in chronic kidney disease: Mere consequence or also culprit? Pflugers Arch. 2024;476(4):579–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korsunsky I, Wei K, Pohin M, Kim EY, Barone F, Major T, Taylor E, Ravindran R, Kemble S, Watts GFM, Jonsson AH, Jeong Y, Athar H, Windell D, Kang JB, Friedrich M, Turner J, Nayar S, Fisher BA, Raza K, Marshall JL, Croft AP, Tamura T, Sholl LM, Vivero M, Rosas IO, Bowman SJ, Coles M, Frei AP, Lassen K, Filer A, Powrie F, Buckley CD, Brenner MB, Raychaudhuri S. Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases. Med. 2022;3(7):481–e51814.

Article  CAS  PubMed  Google Scholar 

Farah H, Young SP, Mauro C, Jones SW. Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts. FEBS J. 2021;288(19):5555–68.

Article  CAS  PubMed  Google Scholar 

Schulz MC, Kopf M, Gekle M. Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling. Cell Commun Signal. 2024;22(1):148.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Upadhyay A, Larson MG, Guo CY, Vasan RS, Lipinska I, O’Donnell CJ, Kathiresan S, Meigs JB, Keaney JF Jr., Rong J, Benjamin EJ, Fox CS. Inflammation, kidney function and albuminuria in the Framingham offspring cohort. Nephrol Dial Transpl. 2011;26(3):920–6.

Article  CAS  Google Scholar 

Feigerlova E, Battaglia-Hsu SF. IL-6 signaling in diabetic nephropathy: from pathophysiology to therapeutic perspectives. Cytokine Growth Factor Rev. 2017;37:57–65.

Article  CAS  PubMed  Google Scholar 

Yeung YT, Aziz F, Guerrero-Castilla A, Arguelles S. Signaling pathways in inflammation and Anti-inflammatory therapies. Curr Pharm Des. 2018;24(14):1449–84.

Article  CAS  PubMed  Google Scholar 

Hoesel B, Schmid JA. The complexity of NF-kappaB signaling in inflammation and cancer. Mol Cancer. 2013;12:86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. J Biol Chem. 1999;274(20):14434–43.

Article  CAS  PubMed  Google Scholar 

Radnaa E, Richardson L, Goldman B, Burks JK, Baljinnyam T, Vora N, Zhang HJ, Bonney EA, Han A, Menon R. Stress signaler p38 mitogen-activated kinase activation: a cause for concern? Clin Sci (Lond). 2022;136(22):1591–614.

Article  CAS  PubMed  Google Scholar 

Riemann A, Wussling H, Loppnow H, Fu H, Reime S, Thews O. Acidosis differently modulates the inflammatory program in monocytes and macrophages. Biochim Biophys Acta. 2016;1862(1):72–81.

Article  CAS  PubMed  Google Scholar 

Zhu G, Liu Y, Zhi Y, Jin Y, Li J, Shi W, Liu Y, Han Y, Yu S, Jiang J, Zhao X. Ca(2+)-dependent p38 MAPK/CREB activation protects against manganese-mediated neuronal apoptosis. Toxicol Lett. 2019;309:10–9.

Article  CAS  PubMed  Google Scholar 

Chava KR, Karpurapu M, Wang D, Bhanoori M, Kundumani-Sridharan V, Zhang Q, Ichiki T, Glasgow WC, Rao GN. CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Arterioscler Thromb Vasc Biol. 2009;29(6):809–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rauschner M, Reime S, Riemann A, Thews O. Acidosis-Induced regulation of Egr1 and Ccn1 in vitro and in experimental tumours in vivo. Adv Exp Med Biol. 2022;1395:243–8.

Article  CAS  PubMed  Google Scholar 

Ross JA, Barrett B, Bensimon V, Shukla G, Weyman CM. Basal signalling through death receptor 5 and caspase 3 activates p38 kinase to regulate serum response factor (SRF)-Mediated myod transcription. J Mol Signal. 2020;14:1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guerci A, Lahoute C, Hebrard S, Collard L, Graindorge D, Favier M, Cagnard N, Batonnet-Pichon S, Precigout G, Garcia L, Tuil D, Daegelen D, Sotiropoulos A. Srf-dependent paracrine signals produced by myofibers control satellite cell-mediated skeletal muscle hypertrophy. Cell Metab. 2012;15(1):25–37.

Article  CAS  PubMed  Google Scholar 

Ponti C, Gibellini D, Boin F, Melloni E, Manzoli FA, Cocco L, Zauli G, Vitale M. Role of CREB transcription factor in c-fos activation in natural killer cells. Eur J Immunol. 2002;32(12):3358–65.

Article  CAS  PubMed  Google Scholar 

Buchwalter G, Gross C, Wasylyk B. Ets ternary complex transcription factors. Gene. 2004;324:1–14.

Article  CAS  PubMed  Google Scholar 

Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Forstner P, Garrett L, Holter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, Adamski J, Wolf E, Bekeredjian R, Fuchs H, Gailus-Durner V, de Angelis MH, Knoll B. Serum response factor (SRF) ablation interferes with acute Stress-Associated immediate and Long-Term coping mechanisms. Mol Neurobiol. 2017;54(10):8242–62.

Article  CAS  PubMed  Google Scholar 

Karkoulias G, McCrink KA, Maning J, Pollard CM, Desimine VL, Patsouras N, Psallidopoulos M, Taraviras S, Lymperopoulos A, Flordellis C. Sustained GRK2-dependent CREB activation is essential for alpha(2)-adrenergic receptor-induced PC12 neuronal differentiation. Cell Signal. 2020;66:109446.

Article  CAS  PubMed  Google Scholar 

Wu Y, Angelov B, Deng Y, Fujino T, Hossain MS, Drechsler M, Angelova A. Sustained CREB phosphorylation by lipid-peptide liquid crystalline nanoassemblies. Commun Chem. 2023;6(1):241.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lue H, Kapurniotu A, Fingerle-Rowson G, Roger T, Leng L, Thiele M, Calandra T, Bucala R, Bernhagen J. Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity. Cell Signal. 2006;18(5):688–703.